Slide 1
... become much stronger and it becomes possible to decrease CO pressure without causing catalyst decomposition. becomes stronger Bulkier PR3 favor greater linear / branched becomes more hydride-like H aldehyde ratios ( up to 8 : 1). CO Finally, more hydride-like Co-H promotes aldehyde OC Co hydrogenati ...
... become much stronger and it becomes possible to decrease CO pressure without causing catalyst decomposition. becomes stronger Bulkier PR3 favor greater linear / branched becomes more hydride-like H aldehyde ratios ( up to 8 : 1). CO Finally, more hydride-like Co-H promotes aldehyde OC Co hydrogenati ...
Chapter 10: Alkyl Halides
... Allylic Bromination with NBS is analogous to the radical reaction with an alkane, a halogen and uv light (Ch. 5). The NBS can be thought of as producing a Br radical. The Br radical removes a hydrogen, leaving an allylic radical and forming HBr. This allylic radical reacts with Br2 (which is formed ...
... Allylic Bromination with NBS is analogous to the radical reaction with an alkane, a halogen and uv light (Ch. 5). The NBS can be thought of as producing a Br radical. The Br radical removes a hydrogen, leaving an allylic radical and forming HBr. This allylic radical reacts with Br2 (which is formed ...
HOCl wt/wt 0.06 x mL 90 one cy
... C2O42- → 2CO2 (good no further atomic balancing required) Step 4: Balance the hydrogens from water with H+ (on other side) 8H+ + MnO4− → Mn2+ + 4H2O Step 5: Balance the charges of the half reaction using electrons. 5e− + 8H+ + MnO4− → Mn2+ + 4H2O C2O42- → 2CO2 + 2e− Step 6: Determine the common numb ...
... C2O42- → 2CO2 (good no further atomic balancing required) Step 4: Balance the hydrogens from water with H+ (on other side) 8H+ + MnO4− → Mn2+ + 4H2O Step 5: Balance the charges of the half reaction using electrons. 5e− + 8H+ + MnO4− → Mn2+ + 4H2O C2O42- → 2CO2 + 2e− Step 6: Determine the common numb ...
Carbonyl Alpha-Substitution Reactions
... their positions by reaction with Cl2, Br2, or I2 in acidic solution ...
... their positions by reaction with Cl2, Br2, or I2 in acidic solution ...
Prof_Elias_Inorg_lec_6
... Reactions of Ferrocene Ferrocene undergoes electrophilic substitution reactions. Many of its reactions are faster than similar reactions of benzene Necessary requirement: The electrophile should not be oxidizing in nature ...
... Reactions of Ferrocene Ferrocene undergoes electrophilic substitution reactions. Many of its reactions are faster than similar reactions of benzene Necessary requirement: The electrophile should not be oxidizing in nature ...
Experiment #3: Asymmetric Synthesis – Use of a Chiral Manganese
... these reactions by allowing enantioselective oxygen transfer to form asymmetric epoxides. The most prevalent of these systems has been the oxidation of prochiral allylic alcohols (which uses tert-butyl hydroperoxide in the presence of titanium tetra(isopropoxide) and either (+)- or (-)-diethyl tartr ...
... these reactions by allowing enantioselective oxygen transfer to form asymmetric epoxides. The most prevalent of these systems has been the oxidation of prochiral allylic alcohols (which uses tert-butyl hydroperoxide in the presence of titanium tetra(isopropoxide) and either (+)- or (-)-diethyl tartr ...
Chapter 16: Ethers, Epoxides, and Sulfides
... (The workhorse of ether syntheses) Reaction of an alkoxide with an alkyl halide or tosylate to give an ether. Alkoxides are prepared by the reaction of an alcohol with a strong base such as sodium hydride (NaH) ...
... (The workhorse of ether syntheses) Reaction of an alkoxide with an alkyl halide or tosylate to give an ether. Alkoxides are prepared by the reaction of an alcohol with a strong base such as sodium hydride (NaH) ...
MOLES AND CALCULATIONS USING THE MOLE CONCEPT
... 1. A mole is the amount of any substance that contains as many elementary entities as there are atoms in exactly 1.00 g of hydrogen-1. 2. A mole is the amount ... in exactly 12.00 g of carbon-12. 3. 6.02 x 1023 of anything 4. It is important to state the entities involved: ...
... 1. A mole is the amount of any substance that contains as many elementary entities as there are atoms in exactly 1.00 g of hydrogen-1. 2. A mole is the amount ... in exactly 12.00 g of carbon-12. 3. 6.02 x 1023 of anything 4. It is important to state the entities involved: ...
EXPERIMENT 3: Preparation and Reactivity of Alkyl Halides
... In this case, the reaction mechanism is SN1, the slow step being the breaking of the carbonhalogen bond. The carbocation then reacts rapidly with alcohol to form the ether. Organic halide reactivity parallels the stability of the corresponding carbocations. For saturated alkyl groups, this order is ...
... In this case, the reaction mechanism is SN1, the slow step being the breaking of the carbonhalogen bond. The carbocation then reacts rapidly with alcohol to form the ether. Organic halide reactivity parallels the stability of the corresponding carbocations. For saturated alkyl groups, this order is ...
CHE 312 Exam III Review Sheet - Saint Leo University Faculty
... 5. Know the reaction and mechanism for phenol with carbon dioxide in the presence of hydroxide ion. 6. Be able to explain how an ortho-, para- director works and how to identify it without memorization. Be able to do the same with a meta- director. 7. Be able to do synthesis and complete the reactio ...
... 5. Know the reaction and mechanism for phenol with carbon dioxide in the presence of hydroxide ion. 6. Be able to explain how an ortho-, para- director works and how to identify it without memorization. Be able to do the same with a meta- director. 7. Be able to do synthesis and complete the reactio ...
LOYOLA COLLEGE (AUTONOMOUS), CHENNAI – 600 034 PART-A
... 12. State and explain the Hammond postulate to the bromination of n-propane. 13. How will you determine the reaction mechanism of hydrolysis of an ester using isotoping labeling method? 14. Write and explain the Steven’s rearrangement. 15. Predict the product and explain the mechanism of the followi ...
... 12. State and explain the Hammond postulate to the bromination of n-propane. 13. How will you determine the reaction mechanism of hydrolysis of an ester using isotoping labeling method? 14. Write and explain the Steven’s rearrangement. 15. Predict the product and explain the mechanism of the followi ...
Chapter 7 Alkenes and Alkynes I
... Rearrangements of carbocations occur if a more stable carbocation can be obtained Example ...
... Rearrangements of carbocations occur if a more stable carbocation can be obtained Example ...
4.6, 4.7 test - A
... The following reaction scheme shows the formation of two amines, K and L, from ...
... The following reaction scheme shows the formation of two amines, K and L, from ...
Week 10 Problem Set (Answers) (4/17, 4/18, 4/19) Reactions and
... it to be symmetrical, the ring itself should be symmetrical. Upon being subjected to oxymercuration-reduction conditions, Compound B yields at least one chiral compound. This is untrue for Compound D. Now you can separate the two possible cyclopropanes you came up with earlier for B and D. Upon reac ...
... it to be symmetrical, the ring itself should be symmetrical. Upon being subjected to oxymercuration-reduction conditions, Compound B yields at least one chiral compound. This is untrue for Compound D. Now you can separate the two possible cyclopropanes you came up with earlier for B and D. Upon reac ...
evans enolate alkylation
... This is critically important because the two enantiomers of the same compounds often/usually have very different properties when in come to biological activity. There are a number of different types of approaches to enantioselective synthesis. They include: 1) Substrate Control -A situation where a ...
... This is critically important because the two enantiomers of the same compounds often/usually have very different properties when in come to biological activity. There are a number of different types of approaches to enantioselective synthesis. They include: 1) Substrate Control -A situation where a ...
Synthesis of Benzyl Acetate from Acetic Anhydride
... Another way to upset the equilibrium is to remove water. This can be done by adding to the reaction mixture molecular sieves, an artificial zeolite, which preferentially adsorb water. Most other drying agents, such as anhydrous sodium sulfate or calcium chloride, will not remove water at the tempera ...
... Another way to upset the equilibrium is to remove water. This can be done by adding to the reaction mixture molecular sieves, an artificial zeolite, which preferentially adsorb water. Most other drying agents, such as anhydrous sodium sulfate or calcium chloride, will not remove water at the tempera ...
11 - DR CLEM KUEK
... The substitution reaction of propane is preferable to an addition reaction of propene because the addition of HCl to propene will result in the formation of unwanted 2-chloropropane. ...
... The substitution reaction of propane is preferable to an addition reaction of propene because the addition of HCl to propene will result in the formation of unwanted 2-chloropropane. ...
Benzocaine Synthesis via Esterification
... After completion of the reflux, allow the reaction mixture to cool to room temperature. Pour the reaction mixture (along with the stir bar) into a 200 mL beaker containing 30 mL of ice water. While stirring this mixture, slowly add approximately 10 mL of a 10% Na2CO3 solution. Gas evolution will be ...
... After completion of the reflux, allow the reaction mixture to cool to room temperature. Pour the reaction mixture (along with the stir bar) into a 200 mL beaker containing 30 mL of ice water. While stirring this mixture, slowly add approximately 10 mL of a 10% Na2CO3 solution. Gas evolution will be ...
Synthesis of Fatty Acids
... Fatty acid synthesis occurs in the adipose tissue and is stimulated by insulin. When blood glucose is high, insulin • moves glucose into the cells, stimulating glycolysis and the oxidation of pyruvate. • produces acetyl CoA for fatty acid synthesis. Two carbons are added to the growing fatty acid ch ...
... Fatty acid synthesis occurs in the adipose tissue and is stimulated by insulin. When blood glucose is high, insulin • moves glucose into the cells, stimulating glycolysis and the oxidation of pyruvate. • produces acetyl CoA for fatty acid synthesis. Two carbons are added to the growing fatty acid ch ...
ROCZNIKI FILOZOFICZNE Tom XXXI, zeszyt 3 — 1983
... In recent years, various silicate minerals, such as montmorillonite, kaoline, zeolites, have been shown to enable the synthesis of such biochemical compounds: amino acids, sugars, lipids, nucleotides, polypeptides, etc. (see for example 1, 21). These successful attempts proved J. Bernal's hypothesis ...
... In recent years, various silicate minerals, such as montmorillonite, kaoline, zeolites, have been shown to enable the synthesis of such biochemical compounds: amino acids, sugars, lipids, nucleotides, polypeptides, etc. (see for example 1, 21). These successful attempts proved J. Bernal's hypothesis ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.