Diels-Alder Reaction
... The Diels-Alder reaction is probably the most familiar example of a reaction type known as a cycloaddition reaction, in which the conjugated p-systems of two reactants join to generate a new ring. The reactants in the Diels-Alder reaction are a 1,3-diene and an alkene called the dienophile. The carb ...
... The Diels-Alder reaction is probably the most familiar example of a reaction type known as a cycloaddition reaction, in which the conjugated p-systems of two reactants join to generate a new ring. The reactants in the Diels-Alder reaction are a 1,3-diene and an alkene called the dienophile. The carb ...
___Mg + ___O ___MgO • Mole : Mole ratio
... reacts with nitrogen gas to form 20.4 grams of ammonia (nitrogen trihydride)? 2) What is the percent yield when 2.37 grams of silver nitrate reacts with sodium hydroxide to produce water, sodium nitrate and 1.55 grams of silver oxide? ...
... reacts with nitrogen gas to form 20.4 grams of ammonia (nitrogen trihydride)? 2) What is the percent yield when 2.37 grams of silver nitrate reacts with sodium hydroxide to produce water, sodium nitrate and 1.55 grams of silver oxide? ...
Document
... • There will be two possible Wittig routes to an alkene. • Analyze the structure retrosynthetically, i.e., work the synthesis out backworks • Disconnect (break the bond of the target that can be formed by a known reaction) the doubly bonded carbons. One becomes the aldehyde or ketone, the other the ...
... • There will be two possible Wittig routes to an alkene. • Analyze the structure retrosynthetically, i.e., work the synthesis out backworks • Disconnect (break the bond of the target that can be formed by a known reaction) the doubly bonded carbons. One becomes the aldehyde or ketone, the other the ...
Octenes from E1 versus E2 Eliminations
... base readily picks up moisture from the atmosphere and turns to a sticky gooey mess. Do not leave the lid off the reagent bottle for more than a few seconds at a time and put it back in the dessicator jar as soon as you are finished with the reagent. Add triethylene glycol to a volume level of 1.5 m ...
... base readily picks up moisture from the atmosphere and turns to a sticky gooey mess. Do not leave the lid off the reagent bottle for more than a few seconds at a time and put it back in the dessicator jar as soon as you are finished with the reagent. Add triethylene glycol to a volume level of 1.5 m ...
Eliminations
... SN1/SN2/E2/E1 summary/comparison: (1) Primary alkyl halides will prefer SN2 unless a strong hindered base is used in which case E2 will be favored. For example, t-‐butoxide is a sterically hindered base. ...
... SN1/SN2/E2/E1 summary/comparison: (1) Primary alkyl halides will prefer SN2 unless a strong hindered base is used in which case E2 will be favored. For example, t-‐butoxide is a sterically hindered base. ...
Organometallic Compounds
... The next slides recall the diversity of nucleophiles that may be used. Observe that there is limited opportunity of creating new C-C bonds, welding together two R groups. We seem to be somewhat lacking in simple carbon based nucleophiles. ...
... The next slides recall the diversity of nucleophiles that may be used. Observe that there is limited opportunity of creating new C-C bonds, welding together two R groups. We seem to be somewhat lacking in simple carbon based nucleophiles. ...
131 Learning Objectives
... Name organic compounds with carbon-heteroatom single bonds (oxygen, halogens, sulfur) Identify 1°, 2°, 3° alcohols and alkyl halides Predict the products or reactants for following reactions: Alcohol dehydration Alcohol oxidation Sulfur oxidation Sulfur reduction Chapter 15: The 3-D Shape of M ...
... Name organic compounds with carbon-heteroatom single bonds (oxygen, halogens, sulfur) Identify 1°, 2°, 3° alcohols and alkyl halides Predict the products or reactants for following reactions: Alcohol dehydration Alcohol oxidation Sulfur oxidation Sulfur reduction Chapter 15: The 3-D Shape of M ...
protecting groups
... The simplest protection of the OH group is the methyl ether Protects alcohols and phenols from a variety of chemical conditions Difficult to remove, removal is not as difficult with phenols ...
... The simplest protection of the OH group is the methyl ether Protects alcohols and phenols from a variety of chemical conditions Difficult to remove, removal is not as difficult with phenols ...
Solution Key - Chemistry With BT
... Is the stereoisomer obtained in the reaction above optically active? Explain. No, it is not possible to obtain a chiral product from an achiral reactant unless chiral reaction conditions are utilized, such as enzyme catalysis ...
... Is the stereoisomer obtained in the reaction above optically active? Explain. No, it is not possible to obtain a chiral product from an achiral reactant unless chiral reaction conditions are utilized, such as enzyme catalysis ...
effective: september 2003 curriculum guidelines
... Upon completion of this course, the students will be able to: 1. given the formula, I.R., U.V., mass spect., 1H and 13C N.M.R.’s of an unknown organic compound, be able to determine the structure of that unknown. 2. given the structural formula of an organic compound, be able to predict the number o ...
... Upon completion of this course, the students will be able to: 1. given the formula, I.R., U.V., mass spect., 1H and 13C N.M.R.’s of an unknown organic compound, be able to determine the structure of that unknown. 2. given the structural formula of an organic compound, be able to predict the number o ...
The Baylis–Hillman reaction is an organic reaction of an aldehyde
... Due to a number of factors, including the reversibility of the reaction, as well as the tendency for easy epimerization of the nitro-substituted carbon atom, the Henry Reaction will typically produce a mixture of enantiomers or diastereomers. It is for this reason that explanations for stereoselect ...
... Due to a number of factors, including the reversibility of the reaction, as well as the tendency for easy epimerization of the nitro-substituted carbon atom, the Henry Reaction will typically produce a mixture of enantiomers or diastereomers. It is for this reason that explanations for stereoselect ...
Research Proposals
... – Application of new gc methods (head space with spme) – Use of more sensitive and better computerized instrumentation: gc-ms, nmr, ftir. ...
... – Application of new gc methods (head space with spme) – Use of more sensitive and better computerized instrumentation: gc-ms, nmr, ftir. ...
Zn mediated regioselective Barbier reaction of propargylic bromides
... The regioselectivity of this reaction is highly dependent on the nature of the propargyl halide and carbonyl compound, steric hindrances, solvent effects and the metal used. Use of cheap zinc powder in the Barbier reactions of substituted propargylic halides in water gave a mixture of allenic and pr ...
... The regioselectivity of this reaction is highly dependent on the nature of the propargyl halide and carbonyl compound, steric hindrances, solvent effects and the metal used. Use of cheap zinc powder in the Barbier reactions of substituted propargylic halides in water gave a mixture of allenic and pr ...
doc
... One of the most valuable reactions of alkyllithiums is the preparation of diorganocopper compounds or Gilman reagents. Preparation of Gilman Reagents ...
... One of the most valuable reactions of alkyllithiums is the preparation of diorganocopper compounds or Gilman reagents. Preparation of Gilman Reagents ...
New process of low-temperature methanol synthesis from CO/CO2
... HCOOCH3 is possibly resulted from the reactions of HCOO and CH3OH and/or of HCOOR and CH3OH. The variations of the total carbon conversions with reaction time using 2-propanol and 2-pentanol as solvents separately are shown in fig. 2, where the reaction time is 20 h. The variation of the total carbo ...
... HCOOCH3 is possibly resulted from the reactions of HCOO and CH3OH and/or of HCOOR and CH3OH. The variations of the total carbon conversions with reaction time using 2-propanol and 2-pentanol as solvents separately are shown in fig. 2, where the reaction time is 20 h. The variation of the total carbo ...
Asymmetric Catalytic Aldol
... • Aldolases are a specific group of lysases that catalyse the stereoselective addition of a ketone donor to an aldehyde acceptor. • Over 30 have been identified to date • Type I aldolases are primarily found in animals and plants and activate the donor by forming a schiff base as an intermediate. • ...
... • Aldolases are a specific group of lysases that catalyse the stereoselective addition of a ketone donor to an aldehyde acceptor. • Over 30 have been identified to date • Type I aldolases are primarily found in animals and plants and activate the donor by forming a schiff base as an intermediate. • ...
Week 11 Problem Set (Solutions)
... If you did not generate the stereoisomers, you should at least write out the constitutional isomers (without stereochem) to help you visualize which isomer(s) would be appropriate for specific boxes. Looking at the top section, let’s start by filling in with what we know. Only two structures are pro ...
... If you did not generate the stereoisomers, you should at least write out the constitutional isomers (without stereochem) to help you visualize which isomer(s) would be appropriate for specific boxes. Looking at the top section, let’s start by filling in with what we know. Only two structures are pro ...
Ch 23 Carbonyl Condensations
... - The -hydroxyl can be removed along with an H to create a bond. The result is a conjugated enone (or enal). - This also drives the aldol reaction’s equilibrium towards the products. - The dehydration can be catalyzed either by acid or base, along with mild heating. - The base-catalyzed reactio ...
... - The -hydroxyl can be removed along with an H to create a bond. The result is a conjugated enone (or enal). - This also drives the aldol reaction’s equilibrium towards the products. - The dehydration can be catalyzed either by acid or base, along with mild heating. - The base-catalyzed reactio ...
Application of IBX Method for the Synthesis of Ketones from
... changed into its chloride. Then the acid chloride reacts with an organometallic reagent or gives a FriedelCrafts type reaction in the presence of Lewis acids. These methods are very useful for most aliphatic acid halides and good yields can be obtained in this way. However, if this method is used fo ...
... changed into its chloride. Then the acid chloride reacts with an organometallic reagent or gives a FriedelCrafts type reaction in the presence of Lewis acids. These methods are very useful for most aliphatic acid halides and good yields can be obtained in this way. However, if this method is used fo ...
Notes 07 Organometallic Compounds
... Creation of new C-C bonds. ______________are best, otherwise an elimination reaction can occur. The R’ group in the halide can be ______________ The R group of the cuprate can be ______________ Although the mechanism looks like a _________ reaction, it is more complex and is not well understood. ...
... Creation of new C-C bonds. ______________are best, otherwise an elimination reaction can occur. The R’ group in the halide can be ______________ The R group of the cuprate can be ______________ Although the mechanism looks like a _________ reaction, it is more complex and is not well understood. ...
Aldehydes and ketones
... Explain why Tollens reagent can be used to distinguish an aldehyde from either an alcohol or a ketone? ...
... Explain why Tollens reagent can be used to distinguish an aldehyde from either an alcohol or a ketone? ...
jeep 2014 - apres midi jeunes chercheurs
... Baylis-Hillman reaction of HMF and analogues in bio-based solvent-water mixtures Jia-Neng TAN, Mohammed AHMAR, Yves QUENEAU ...
... Baylis-Hillman reaction of HMF and analogues in bio-based solvent-water mixtures Jia-Neng TAN, Mohammed AHMAR, Yves QUENEAU ...
KFUPM
... In the synthesis of aspartame, the starting materials are a racemic mixture (equal quantities of both isomers) of phenylalanine, and aspartic acid. Only the L isomer of phenylalanine is deisred for use. This L isomer may be separated from the D isomer by a chemical pretreatment, followed by a reacti ...
... In the synthesis of aspartame, the starting materials are a racemic mixture (equal quantities of both isomers) of phenylalanine, and aspartic acid. Only the L isomer of phenylalanine is deisred for use. This L isomer may be separated from the D isomer by a chemical pretreatment, followed by a reacti ...
Alkynes
... forms new carbon-carbon bonds in high yield only with unhindered CH3X and 1° alkyl halides. ...
... forms new carbon-carbon bonds in high yield only with unhindered CH3X and 1° alkyl halides. ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.