Abstracts - Thieme Verlag
... This chapter provides a concise overview of metal-catalyzed additions to alkenes that involve carbon monoxide and another nucleophilic species, such as water or an alcohol. This is an important area of research in terms of several commodity chemical targets, with many papers devoted to the evolution ...
... This chapter provides a concise overview of metal-catalyzed additions to alkenes that involve carbon monoxide and another nucleophilic species, such as water or an alcohol. This is an important area of research in terms of several commodity chemical targets, with many papers devoted to the evolution ...
Additional file 1
... filtrate was concentrated under vacuum and the residue was purified by chromatography to yield ketone 3. 1H NMR (CDCl3) 2.73 (s, 3H), 3.42 (s, 4H), 7.29 (d, 1H), 7.35 (d, 1H), 7.57 (t, 1H), 8.06 (d, 1H), 8.71 (d, 1H). 4-Acenaphthen-5-yl-2,4-dioxo-butyric acid ethyl ester2 (4): Diethyl oxalate (1.0 ...
... filtrate was concentrated under vacuum and the residue was purified by chromatography to yield ketone 3. 1H NMR (CDCl3) 2.73 (s, 3H), 3.42 (s, 4H), 7.29 (d, 1H), 7.35 (d, 1H), 7.57 (t, 1H), 8.06 (d, 1H), 8.71 (d, 1H). 4-Acenaphthen-5-yl-2,4-dioxo-butyric acid ethyl ester2 (4): Diethyl oxalate (1.0 ...
The Shell Higher Olefins Process (SHOP)
... 2. Double bond isomerization over a solid potassium metal catalyst to give an equilibrium mixture of internal alkenes. This step is needed to increase the statistical distribution of the desired C10C14 fraction: ...
... 2. Double bond isomerization over a solid potassium metal catalyst to give an equilibrium mixture of internal alkenes. This step is needed to increase the statistical distribution of the desired C10C14 fraction: ...
OXAZOLINES: THEIR SYNTHESIS AND BIOLOGICAL ACTIVITY
... Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal ...
... Oxazoline moiety constitutes the core structure of many biologically active natural compounds. Oxazoline play a major role in medicinal chemistry. Heterocyclic compounds whose containing oxazoline moiety as core structure reported wide range of biological activities such as antibacterial, antifungal ...
Starter S-30
... Reactions rarely produce as much product as is predicted -reactants can be impure -reactions may not go to completion -may compete with smaller “side” reactions In some reactions as little as 60% yield is considered a good result ...
... Reactions rarely produce as much product as is predicted -reactants can be impure -reactions may not go to completion -may compete with smaller “side” reactions In some reactions as little as 60% yield is considered a good result ...
CaCl2.2H2O assisted oxidation of alcohols with (NH4)2Cr2O7
... in refluxing CH3CN. As shown in the Table I, in most cases, there are appreciable differences between the results obtained in solution and those in solvent free conditions. In conclusion, by omitting the solvent, in addition to ease of the work-up procedure, the reaction time was reduced and the nee ...
... in refluxing CH3CN. As shown in the Table I, in most cases, there are appreciable differences between the results obtained in solution and those in solvent free conditions. In conclusion, by omitting the solvent, in addition to ease of the work-up procedure, the reaction time was reduced and the nee ...
Chapter 10_Organohalides
... • Not very useful to the lack of control over the reaction and can lead ...
... • Not very useful to the lack of control over the reaction and can lead ...
Organic Pathways
... • The formation of isomers and other byproducts also needs to be considered. • The methods of separation of the desired intermediate and final product from isomers and other by-products must be determined. • The final product then needs to be purified and the purity evaluated. • The yield must also ...
... • The formation of isomers and other byproducts also needs to be considered. • The methods of separation of the desired intermediate and final product from isomers and other by-products must be determined. • The final product then needs to be purified and the purity evaluated. • The yield must also ...
Answer Key for Final Exam
... 11. Consider all the data shown below, and determine the structure of the unknown molecule. Assign every peak in the 1H NMR and 13C NMR to atoms in the molecule. Also identify key peak(s) in the IR spectrum and MS spectrum (20 points). Molecular formula: C11H14O2 ...
... 11. Consider all the data shown below, and determine the structure of the unknown molecule. Assign every peak in the 1H NMR and 13C NMR to atoms in the molecule. Also identify key peak(s) in the IR spectrum and MS spectrum (20 points). Molecular formula: C11H14O2 ...
Chem 30BL_Lecture 2_.. - UCLA Chemistry and Biochemistry
... will be poor (theoretically: 73 % at 25 oC) The literature reports an isolated yield of 85 % for the reaction when using concentrated phosphoric acid as catalyst. How? The yield can be improved using the Le Châtelier Principle ...
... will be poor (theoretically: 73 % at 25 oC) The literature reports an isolated yield of 85 % for the reaction when using concentrated phosphoric acid as catalyst. How? The yield can be improved using the Le Châtelier Principle ...
Exam 1
... (i) Show the step-by-step process required to produce propyllithium, which requires a free radical reaction mechanism, . (ii) Show the complete reaction mechanism for reaction between propyllithium and the correct ketone to produce 3-propyl-3-pentanol. (iii) Propose a possible reaction mechanism by ...
... (i) Show the step-by-step process required to produce propyllithium, which requires a free radical reaction mechanism, . (ii) Show the complete reaction mechanism for reaction between propyllithium and the correct ketone to produce 3-propyl-3-pentanol. (iii) Propose a possible reaction mechanism by ...
Lecture 2 - UCLA Chemistry and Biochemistry
... • Catalytic reduction of an alkyne i.e., Lindlar catalyst (Pd) to form cis-alkenes, Na/NH3(l) to form trans-alkenes • Wittig reaction (R’R”C=PR3) from an aldehyde or ketone • Tebbe’s reagent ((C5H5)2Ti(m2-CH2)(m2-Cl)Al(CH3)2) from an aldehyde or ketone (the CH2 group is transferred here to for a ter ...
... • Catalytic reduction of an alkyne i.e., Lindlar catalyst (Pd) to form cis-alkenes, Na/NH3(l) to form trans-alkenes • Wittig reaction (R’R”C=PR3) from an aldehyde or ketone • Tebbe’s reagent ((C5H5)2Ti(m2-CH2)(m2-Cl)Al(CH3)2) from an aldehyde or ketone (the CH2 group is transferred here to for a ter ...
Chem 30BL * Lecture 2 - UCLA Chemistry and Biochemistry
... will be poor (theoretically: 73 % at 25 oC) The literature reports an isolated yield of 85 % for the reaction when using concentrated phosphoric acid as catalyst. How? The yield can be improved using the Le Châtelier Principle ...
... will be poor (theoretically: 73 % at 25 oC) The literature reports an isolated yield of 85 % for the reaction when using concentrated phosphoric acid as catalyst. How? The yield can be improved using the Le Châtelier Principle ...
A-level Paper 2 Practice Paper 1 - A
... Cetrimide is used as an antiseptic. [CH3(CH2)15N(CH3)3]+ Br– cetrimide Name this type of compound. Give the reagent that must be added to CH3(CH2)15NH2 to make cetrimide and state the reaction conditions. Name the type of mechanism involved in this reaction. ...
... Cetrimide is used as an antiseptic. [CH3(CH2)15N(CH3)3]+ Br– cetrimide Name this type of compound. Give the reagent that must be added to CH3(CH2)15NH2 to make cetrimide and state the reaction conditions. Name the type of mechanism involved in this reaction. ...
Alcohol oxidation
... bond. Furthermore, the borane acts as a lewis acid by accepting two electrons in its empty p orbital from an alkene that is electron rich. This process allows boron to have an electron octet. A very interesting characteristic of this process is that it does not require any activation by a catalyst. ...
... bond. Furthermore, the borane acts as a lewis acid by accepting two electrons in its empty p orbital from an alkene that is electron rich. This process allows boron to have an electron octet. A very interesting characteristic of this process is that it does not require any activation by a catalyst. ...
Chap Thirteen: Alcohols
... Propose a reaction or sequence of reactions to produce a target alcohol in high yield. Predict the stereochemistry and optical activity of a product from an understanding of its mechanism of formation. Predict the acidity of alcohols relative to one another and relative to other functional gro ...
... Propose a reaction or sequence of reactions to produce a target alcohol in high yield. Predict the stereochemistry and optical activity of a product from an understanding of its mechanism of formation. Predict the acidity of alcohols relative to one another and relative to other functional gro ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.