Chris Sprout”s
... have been synthesizing amino acid based based ligands in a modular fashion. The ligands are used in the dialkylzinc addition to aldehydes. I have found that Me2Zn, in the presence of our ligands, adds to 2-naphthaldehyde, 4-Cl-benzaldehyde, and benzaldehyde in 86%, 84%, and 81% enantiomeric excess ( ...
... have been synthesizing amino acid based based ligands in a modular fashion. The ligands are used in the dialkylzinc addition to aldehydes. I have found that Me2Zn, in the presence of our ligands, adds to 2-naphthaldehyde, 4-Cl-benzaldehyde, and benzaldehyde in 86%, 84%, and 81% enantiomeric excess ( ...
Chemistry: Selected Topics
... The aim of the course is to acquaint the students with the properties and synthesis of some important types of chemical compounds. In the first part of the course, the general concepts of chemical reaction kinetics are presented with emphasis on the relation between reaction rate and reaction mechan ...
... The aim of the course is to acquaint the students with the properties and synthesis of some important types of chemical compounds. In the first part of the course, the general concepts of chemical reaction kinetics are presented with emphasis on the relation between reaction rate and reaction mechan ...
Dormancy Metabolism Characteristics
... 2. Constitutional dormancy - germination is delayed by an innate property of the spore* 3. Exogenous dormancy - development is delayed only because of one or more unfavorable chemical or physical conditions of the environment** *a) b) c) d) ...
... 2. Constitutional dormancy - germination is delayed by an innate property of the spore* 3. Exogenous dormancy - development is delayed only because of one or more unfavorable chemical or physical conditions of the environment** *a) b) c) d) ...
Background Information
... When condensation products (β-hydroxycarbonyl compounds) undergo E2 elimination, the resulting product is referred to as an α,β-unsaturated carbonyl. In the case of the dibenzalacetone reaction, the product is referred to as an α,β-unsaturated ketone. These products are very stable (due to resonance ...
... When condensation products (β-hydroxycarbonyl compounds) undergo E2 elimination, the resulting product is referred to as an α,β-unsaturated carbonyl. In the case of the dibenzalacetone reaction, the product is referred to as an α,β-unsaturated ketone. These products are very stable (due to resonance ...
Novel Synthesis of Schiff bases Bearing Glucosamine Moiety
... a possibility of tautomeric and anomeric equilibria has to be taken into consideration. Dziembowska et al. studied the structure of some glucosamine Schiff bases by means of ab initio calculations and the anomeric and tautomeric equilibria in a DMSO solution by spectroscopic methods9. Kunz et al. ha ...
... a possibility of tautomeric and anomeric equilibria has to be taken into consideration. Dziembowska et al. studied the structure of some glucosamine Schiff bases by means of ab initio calculations and the anomeric and tautomeric equilibria in a DMSO solution by spectroscopic methods9. Kunz et al. ha ...
IOSR Journal of Applied Chemistry (IOSR-JAC)
... excellent activity when aromatic substitutions are present at 2- and/or 6-positions. Mannich reaction is one of the multi-component reactions for the carbon-carbon and carbon heteroatom sequential bond formation. Mannich type condensation involving aromatic aldehydes, ammonium acetate and ketones ha ...
... excellent activity when aromatic substitutions are present at 2- and/or 6-positions. Mannich reaction is one of the multi-component reactions for the carbon-carbon and carbon heteroatom sequential bond formation. Mannich type condensation involving aromatic aldehydes, ammonium acetate and ketones ha ...
Scheme I a la 2a 3a d ~ ~`~ .~ff 3 4a 5a
... obtained using this procedure. 9. A solution of 2d (28.0 g, 99.5 mmol) and triethylamine (28 mL, 199 mmol) in CH2C12 (330 mL) at -3°C was treated over 2.5h with methane sulfonyl chloride (8.5 mL) in CH2C12(8.5 mL). The resulting brown slurry was stirred for an additional 2.5h. All volatiles were rem ...
... obtained using this procedure. 9. A solution of 2d (28.0 g, 99.5 mmol) and triethylamine (28 mL, 199 mmol) in CH2C12 (330 mL) at -3°C was treated over 2.5h with methane sulfonyl chloride (8.5 mL) in CH2C12(8.5 mL). The resulting brown slurry was stirred for an additional 2.5h. All volatiles were rem ...
Williamson Ether Synthesis
... Since the Williamson synthesis is a SN2 substitution reaction, an inversion of configuration occurs at the carbon bearing the leaving group. The leaving group must be on the opposite side of the molecule from the attacking nucleophile in order for the reaction to occur. ...
... Since the Williamson synthesis is a SN2 substitution reaction, an inversion of configuration occurs at the carbon bearing the leaving group. The leaving group must be on the opposite side of the molecule from the attacking nucleophile in order for the reaction to occur. ...
Preparation of alkyl halides There are lots of ways to make alkyl
... And the overall allylic bromination reaction is shown below: ...
... And the overall allylic bromination reaction is shown below: ...
Types of Reactions in Organic Chemistry Chemistry
... Types of Reactions in Organic Chemistry The mechanism of a reaction is the detailed step-by-step description of how the overall reaction occurs. A substitution reaction is a chemical reaction in which an atom or group of atoms in a molecule is replaced by another atom or group of atoms. A substitut ...
... Types of Reactions in Organic Chemistry The mechanism of a reaction is the detailed step-by-step description of how the overall reaction occurs. A substitution reaction is a chemical reaction in which an atom or group of atoms in a molecule is replaced by another atom or group of atoms. A substitut ...
Microsoft Word
... constraints on the diffusional path of the molecules imposed by the different structural feature of the zeolite, the more bulkier Markovnikov adduct could not be retained in the zeolite pore and presumably for this reason only anti-Markovnikov product was obtained. Thus a facile, heterogeneous catal ...
... constraints on the diffusional path of the molecules imposed by the different structural feature of the zeolite, the more bulkier Markovnikov adduct could not be retained in the zeolite pore and presumably for this reason only anti-Markovnikov product was obtained. Thus a facile, heterogeneous catal ...
Ch.5
... The product(s) of a reaction is/are limited by how much of each reactant is present (available) in the reaction. Two types of reactants Limiting - this is the reactant you run out of first! Excess - at the end of the reaction there will be some of this reactant left over (excess:-)). ...
... The product(s) of a reaction is/are limited by how much of each reactant is present (available) in the reaction. Two types of reactants Limiting - this is the reactant you run out of first! Excess - at the end of the reaction there will be some of this reactant left over (excess:-)). ...
Chapter 7 - Alkenes and Alkynes I less substituted alkene due to
... - Carrying out dehydrohalogenations with a bulky base, such as tert-butxide, favors the formation of the less substituted alkene due to sterics - When an elimination yields the less substituted alkene, it follows the Hofmann Rule - The anticoplanar transition state is preferred, but the syn coplanar ...
... - Carrying out dehydrohalogenations with a bulky base, such as tert-butxide, favors the formation of the less substituted alkene due to sterics - When an elimination yields the less substituted alkene, it follows the Hofmann Rule - The anticoplanar transition state is preferred, but the syn coplanar ...
Chapter 14 Selenium reagents
... reagents, e.g. ArSe-Na+, and carbon electrophiles. On oxidation they give selenoxides; if these contain a -hydrogen, they may undergo spontaneous syn-addition at ambient temp. to give alkenes. Allyl selenoxides undergo rearrangement to allyl selenenates, which are hydrolysable to allylic alcohols. ...
... reagents, e.g. ArSe-Na+, and carbon electrophiles. On oxidation they give selenoxides; if these contain a -hydrogen, they may undergo spontaneous syn-addition at ambient temp. to give alkenes. Allyl selenoxides undergo rearrangement to allyl selenenates, which are hydrolysable to allylic alcohols. ...
Preface - Wiley Online Library
... of two new carbon-carbon bonds (twofold extrusion reactions). This remarkable transformation parlays two important features of nitrogen, first the ease of introduction into carbonyl compounds, this time with hydrazine to form hydrazones, and second the high thermochemical stability of molecular nitr ...
... of two new carbon-carbon bonds (twofold extrusion reactions). This remarkable transformation parlays two important features of nitrogen, first the ease of introduction into carbonyl compounds, this time with hydrazine to form hydrazones, and second the high thermochemical stability of molecular nitr ...
Novel amine-catalysed hydroalkoxylation reactions of
... dihydroalkoxylation reaction of alkynones was intriguing, not least because the products of such reactions would be synthetically useful mono-protected 1,3-dicarbonyl compounds. Treatment of terminal alkyne 23 with ethylene glycol in the presence of 5 mol% DMAP12 gave smooth conversion to acetal 24, ...
... dihydroalkoxylation reaction of alkynones was intriguing, not least because the products of such reactions would be synthetically useful mono-protected 1,3-dicarbonyl compounds. Treatment of terminal alkyne 23 with ethylene glycol in the presence of 5 mol% DMAP12 gave smooth conversion to acetal 24, ...
Chemical Synthesis Using Earth-Abundant Metal
... (i.e., Pd, Pt, Ru, Rh, Ir, Ag and Au). The problem with precious metals is that they are expensive, steadily rarefying, and are generally non-renewable. Catalysts made from these metals can also be harmful to humans and to the environment. ...
... (i.e., Pd, Pt, Ru, Rh, Ir, Ag and Au). The problem with precious metals is that they are expensive, steadily rarefying, and are generally non-renewable. Catalysts made from these metals can also be harmful to humans and to the environment. ...
5 · Chemical Reactions
... You will be given a periodic table and a solubility chart. No other resources are allowed. You have fifty (50) minutes to complete this test, unless other arrangements have been made. Please transfer your answers for questions in Sections 1 and 2 onto the Answer Document. Work for these questions wi ...
... You will be given a periodic table and a solubility chart. No other resources are allowed. You have fifty (50) minutes to complete this test, unless other arrangements have been made. Please transfer your answers for questions in Sections 1 and 2 onto the Answer Document. Work for these questions wi ...
EXP-7
... The Cannizzaro reaction is that of aldehydes that do not contain alpha hydrogens to give carboxylic acids and alcohols (alpha hydrogens cause an Aldol reaction to take place). This occurs in the presence of a strong base. Benzaldehyde, which does not contain alpha hydrogens, was used for this reacti ...
... The Cannizzaro reaction is that of aldehydes that do not contain alpha hydrogens to give carboxylic acids and alcohols (alpha hydrogens cause an Aldol reaction to take place). This occurs in the presence of a strong base. Benzaldehyde, which does not contain alpha hydrogens, was used for this reacti ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.