Advanced Organic chemistry syllabus
... Knowledge and Understanding : Upon completion of the course, students will be able to: 1-Demonstrate the principles of advanced organic chemistry and its related subjects including fundamentals of organic chemistry of drug synthesis. 2- Contribute to the development of medicinal agents through the o ...
... Knowledge and Understanding : Upon completion of the course, students will be able to: 1-Demonstrate the principles of advanced organic chemistry and its related subjects including fundamentals of organic chemistry of drug synthesis. 2- Contribute to the development of medicinal agents through the o ...
Protecting Groups Introduction to Carbonyl
... Protecting Groups Solving this problem requires a three-step strategy: [1] Convert the OH group into another functional group that does not interfere with the desired reaction. This new blocking group is called a protecting group, and the reaction that creates it is called “protection.” [2] Carry ou ...
... Protecting Groups Solving this problem requires a three-step strategy: [1] Convert the OH group into another functional group that does not interfere with the desired reaction. This new blocking group is called a protecting group, and the reaction that creates it is called “protection.” [2] Carry ou ...
Lecture 9a - University of California, Los Angeles
... The problem in this reaction is that aldehydes are generally more reactive than ketones which means that both groups would react with the Grignard reagent, albeit with different rates The higher reactivity of the aldehyde is exploited in the formation of the cyclic acetal using 1,3-propanediol ...
... The problem in this reaction is that aldehydes are generally more reactive than ketones which means that both groups would react with the Grignard reagent, albeit with different rates The higher reactivity of the aldehyde is exploited in the formation of the cyclic acetal using 1,3-propanediol ...
n - TU Chemnitz
... α-Azido alcohols derived from aldehydes are not known in literature but postulated to be unstable intermediates in solvolysis reactions. The synthesis starting from α-azidoalkyl trimethylsilyl ethers,[1] geminal diazides[2] or α-azido ethers[3] only led to the corresponding aldehydes but not to α-az ...
... α-Azido alcohols derived from aldehydes are not known in literature but postulated to be unstable intermediates in solvolysis reactions. The synthesis starting from α-azidoalkyl trimethylsilyl ethers,[1] geminal diazides[2] or α-azido ethers[3] only led to the corresponding aldehydes but not to α-az ...
Lecture 16 Aromatic Diazonium Salts
... The process probably takes place via one-electron reduction of the diazonium ion followed by dimerization of the resulting aryl radicals. ...
... The process probably takes place via one-electron reduction of the diazonium ion followed by dimerization of the resulting aryl radicals. ...
- M E S KVM College Valanchery.
... Hydroformylation of alkenes may lead to alcohol and aldehyde products. Which statement is correct? The stereoselectivity of the reaction gives the aldehyde:alcohol ratio The chemoselectivity of the reaction gives the n:i aldehyde ratio The regioselectivity of the reaction gives the aldehyde:alcohol ...
... Hydroformylation of alkenes may lead to alcohol and aldehyde products. Which statement is correct? The stereoselectivity of the reaction gives the aldehyde:alcohol ratio The chemoselectivity of the reaction gives the n:i aldehyde ratio The regioselectivity of the reaction gives the aldehyde:alcohol ...
Ch 26 C-C bond formation
... • Cyclopropanation is a concerted reaction, so both bonds are formed in a single step. • Carbene addition occurs in a syn fashion from either side of the planer double bond. • Carbene addition is a stereospecific reaction, since cis and trans alkenes yield different stereoisomers as products. ...
... • Cyclopropanation is a concerted reaction, so both bonds are formed in a single step. • Carbene addition occurs in a syn fashion from either side of the planer double bond. • Carbene addition is a stereospecific reaction, since cis and trans alkenes yield different stereoisomers as products. ...
The carbonyl functional group Formation of the C=O group π
... Distinguish between an aldehyde & Ketone Oxidation of an aldehyde using Tollens’ reagent (alkaline conditions – NaOH added to silver nitrate) ...
... Distinguish between an aldehyde & Ketone Oxidation of an aldehyde using Tollens’ reagent (alkaline conditions – NaOH added to silver nitrate) ...
Enzymatic synthesis of sialic acid derivative by immobilized lipase
... 435 was observed to efficiently catalyze the esterification of N-acetyl neuraminic acid methyl ester with nonanoic anhydride and appeared to be suitable for SAMEMN production. 3.2. Effects of reaction time and temperature on SAMEMN production A time course was produced to monitor reaction progress and ...
... 435 was observed to efficiently catalyze the esterification of N-acetyl neuraminic acid methyl ester with nonanoic anhydride and appeared to be suitable for SAMEMN production. 3.2. Effects of reaction time and temperature on SAMEMN production A time course was produced to monitor reaction progress and ...
الشريحة 1 - Systematic Approach to Teaching
... if we do the study for each of the function groups separately without making the relation between them, this will be the linear approach of teaching. ...
... if we do the study for each of the function groups separately without making the relation between them, this will be the linear approach of teaching. ...
Exam 2 SOLUTION
... Please work in the space provided. Box your answers to set them off. The last page may be torn off and used for scratch paper. Bring all materials up when you are finished with the exam. Good luck! 1. Predict the product, or give the starting material for the following reactions: [12] ...
... Please work in the space provided. Box your answers to set them off. The last page may be torn off and used for scratch paper. Bring all materials up when you are finished with the exam. Good luck! 1. Predict the product, or give the starting material for the following reactions: [12] ...
... 11. Give a mechanism for the reaction of tert.butyl bromide with aqueous NaOH to form tert.butyl alcohol. 12. Explain Saytzeff rule and Hofmann rule with an example. 13. How is phenol prepared from Cumene. 14. Although both phenol and alcohols contain hydroxyl group, Phenol is acidic whereas aliphat ...
Yeast Reduction #812
... Adapted by Laura Nigbor (Penn State Univ.) from a micro-scale experiment developed by Pascale Besse; Jean Bolte; and Henri Veschambre, published in Journal of Chemical Education. ...
... Adapted by Laura Nigbor (Penn State Univ.) from a micro-scale experiment developed by Pascale Besse; Jean Bolte; and Henri Veschambre, published in Journal of Chemical Education. ...
Structural Characterisation by ESI-MS of Feruloylated Arabino-oligosaccharides Synthesised by Chemoenzymatic Esterification
... FAEs have been used in the synthesis of sugar ferulates such as 5-O-(trans-feruloyl)-L-arabinofuranose [5] or O-[5-O-(trans-feruloyl)-α-L-arabinofuranosyl]-(1→5)-L-arabinofuranose [6]. More specifically, StFaeC catalyzed the transfer of the feruloyl group to L-arabinose and L-arabinobiose in a terna ...
... FAEs have been used in the synthesis of sugar ferulates such as 5-O-(trans-feruloyl)-L-arabinofuranose [5] or O-[5-O-(trans-feruloyl)-α-L-arabinofuranosyl]-(1→5)-L-arabinofuranose [6]. More specifically, StFaeC catalyzed the transfer of the feruloyl group to L-arabinose and L-arabinobiose in a terna ...
Designing Organic Synthesis - Department of Chemistry, IIT Bombay
... Theses simple targets were synthesized by often starting with compounds which are closely related to products These became impractical when the targets became more complex To tackle this, higher level of intellectual planning and skill are required Better understanding of reaction mechanisms A worki ...
... Theses simple targets were synthesized by often starting with compounds which are closely related to products These became impractical when the targets became more complex To tackle this, higher level of intellectual planning and skill are required Better understanding of reaction mechanisms A worki ...
1 Carbonyl Condensation Reactions (Conjugate Addition) If we look
... In this reaction, an enolate is the nuclophile; one aldehyde molecule becomes the enolate while the other molecule serves as the electrophile. With aldehydes, the equilibrium usually favors the aldol products. But with ketones, the equilibrium usually favors starting materials. Of course, there are ...
... In this reaction, an enolate is the nuclophile; one aldehyde molecule becomes the enolate while the other molecule serves as the electrophile. With aldehydes, the equilibrium usually favors the aldol products. But with ketones, the equilibrium usually favors starting materials. Of course, there are ...
Combinatorial chemistry: A novel method in drug discovery and its
... The use of solid support for organic synthesis relies on three interconnected requirements: ...
... The use of solid support for organic synthesis relies on three interconnected requirements: ...
Solid phase reactions II
... lack of methods for acide chloride formation mainly two procedures Steglich: DIC/DMAP Yamaguchi: TCBC (2,4,6-trichlorobenzoylchloride) ...
... lack of methods for acide chloride formation mainly two procedures Steglich: DIC/DMAP Yamaguchi: TCBC (2,4,6-trichlorobenzoylchloride) ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.