Download Advanced Organic chemistry syllabus

The University of Jordan
Accreditation & Quality Assurance Center
COURSE Syllabus
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
1
Course title
Advanced Organic Chemistry
2
1231722
4
Course number
Credit hours (theory, practical)
Contact hours (theory,
practical)
Prerequisites/corequisites
5
Program title
Msc Degree in Pharmaceutical Sciences
6
Program code
7
Awarding institution
The University of Jordan
8
Faculty
Pharmacy
9
Department
Pharmaceutical Chemistry
10
Level of course
PostgraduateYear 1
11
Year of study and semester (s)
2015/2016 First Semester
12
Final Qualification
Other department (s) involved in
teaching the course
None
14
Language of Instruction
English
15
Date of production/revision
01-9-2015
3
13
3 (theory)
3 (theory)
16. Course Coordinator:
Dr Ghadeer suaifan
Office number: 206
Office Phone Number: 2331
Email: [email protected]/[email protected]
Office hours to be announced
17. Other instructors:
Dr Mohammad Khanfar
Office number:
Office Phone Number: 23339
Email: [email protected]
Office hours to be announced
18. Course Description:
This course includes the common organic reactions (classical and recent) including their generic names,
mechanism, reagents, conditions, the required starting materials and their generated products. Advanced
synthetic strategies and retro-synthetic analysis, synthesis of complex natural products with biologically
1
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
interesting molecules such as antibiotics, antihypertensive agents, hormones anticoagulants and antiviral
agents.
19. Course aims and outcomes:
A- Aims:
Provide postgraduate master students with a special and advanced education in the field of
Pharmaceutical organic chemistry and enable them to gain the skills and attributes required for the
responsible practice of Organic chemistry experiments.
B- Intended Learning Outcomes (ILOs): Upon successful completion of this course students will be
able to …
A) Knowledge and understanding:
The course would provides students with excellent opportunities to demonstrate knowledge and
understanding qualities and develop skills appropriate for the design, synthesis and optimize novel
Medicinal Compounds.
Knowledge and Understanding : Upon completion of the course, students will be able to:
1-Demonstrate the principles of advanced organic chemistry and its related subjects including
fundamentals of organic chemistry of drug synthesis.
2- Contribute to the development of medicinal agents through the optimizing and synthesis of novel
drug candidates.
3- Understand up-to-date applications of organic chemistry in drug synthesis.
4- Awareness regarding legal authorities and patency rights
5- Understanding the basics of good laboratory
6- Shows clearly full consciousness of ethics in all aspects of scientific research including novel drug
in vivo testing.
B) Intellectual Skills: Upon completion of the course, students will be able to:
1- Proper handling of chemical reagents and the assignment of safety sheet.
1-Design possible synthetic pathway of a specific drug candidate and predict the reactions
mechanisms.
2- Evaluate the anticipated problems and side reactions that might emerge during the synthesis
process.
3- Develop necessary method for drug target purification.
4- Propose of a laboratory schemes for an advanced medicinal drug synthesis.
5- Be a decisions maker in proposing a synthetic scheme based on material availability, safety, cost
and experiment time.
C) Professional and Practical Skills: Upon completion of the course, students will be able to:
1- Apply professional skills in synthesis and evaluation of different pharmaceutical organic
compounds.
2- Put in writing and discuss the target compound synthetic pathway, proposed mechanism of the
reactions in the form of thesis and scientific papers.
3- Pick up and apply the proper techniques and precaution during the practical work in the lab
D) General and Transferable Skills: Upon completion of the course, students will be able to:
1- Interact effectively with professionals.
2- Search scientific resources to find out the proper scientific materials.
3- Pursuit self estimation in drug synthesis for personal learning needs.
4- Restore information in the field of advanced organic chemistry from different sources.
2
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
5- Apply standards for judging on the performance of other colleagues.
6- Initiate and activate team work.
7- Coordinate and manage research time to get goals.
8- Be an independent learner.
Program Competencies Achieved:
3.1 Identify physiochemical properties of drug substances.
3.11 Identify analytical method development and validation used in pharmaceutical
Analysis.
7.4 Follow new advances in science related to the profession.
7.5 Utilize information technology tools to enhance working experience
20. Topic Outline and Schedule:
Topic
Week
Introduction to
Advanced Organic
chemistry
* Structure and
Mechanism
*Reactions and
Synthesis
*Reaction of alcohol and
phenol
* Reaction of carbonyl
compounds.
* Reaction of alkyl
halide
* Organometalic
reaction
*Reaction of ether,
epoxides and ethers
* Reaction of amine,
amide
* Oxidation reduction
ladder
*Enzyme Catalyzed
Reaction
* Others
Mid term Exam
Heterocyclic Organic
Chemistry
Retro synthesis and
examples on Medicinal
drugs
Synthesis of different
Medicinal Drug
Final Exam
1
Dr Ghadeer
Suaifan
A1-3, B1, C1
2-3
Dr Ghadeer
Suaifan
Dr Ghadeer
Suaifan
A1-3, B1, C1
Dr Ghadeer
Suaifan
Dr Ghadeer
Suaifan
A1-3, B1, C1
Dr Ghadeer
Suaifan
A1-3, B1, C1
3
4-7
8
9-10
11-14
15
16
Instructor
Achieved ILOs
A1-3, B1, C1
A1-3, B1, C1
Evaluatio
n
Methods
Written
Exam
Reference
1,2,3
Written
Exam
Written
Exam
and
Seminars
1,2,3
Written
Exam
Written
Exam
1,2,3
Seminars
1,2,3
1,2,3
1,2,3
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
21. Teaching Methods and Assignments:
Development of ILOs is promoted through the following teaching and learning methods:
Power point presentations, activity workshops, watching videos and lab visiting
ILO/s
Learning Methods
Evaluation Methods
A1-3,
B1, C1
D1
Lectures
Exams
Assignment
Seminars
1.
2.
3.
4.
Critical thinking
Scientific reasoning
Problem-solving skills
Self-directed learning
22. Evaluation Methods and Course Requirements:
Opportunities to demonstrate achievement of the ILOs are provided through the following
assessment methods and requirements:
Written Exam, Seminars, activity workshops, organic laboratory visit, follow up and oral
presentations.
23. Course Policies:
A- Attendance policies:
Students’ attendance must comply with the regulations of The University of Jordan. However, students are
recommended to attend all lectures to fulfil the course purpose
B- Absences from exams and handing in assignments on time:
C- Health and safety procedures:
D- Honesty policy regarding cheating, plagiarism, misbehavior:
E- Grading policy:
Students will fail if they get below 60%. Grade Scale A*, A, B+, B, B-, ...........
F- Available university services that support achievement in the course:
Course evaluation report will be distributed to students by the end of the course to permit self evaluation.
Also, statistical analysis will be held to find out students achievement based on students written exam and
oral presentations results.
24. Required equipment:
Data Show, White board, Computer, Audio system, Organic chemistry lab.
4
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
25. References:
A- Required book (s), assigned reading and audio-visuals:
1234-
Organic Chemistry 9th Edition, Edited by John E. Mc Murry (2015)
An Introduction To Drug Synthesis, Edited by, Graham L. Patrick (2015)
An Introduction To Medicinal Chemistry, 5th Edition, Edited by Graham L. Patrick
The organic chemistry of drug design and drug action ,third edition, Edited by Richard B.
Silverman.(2005)
5- Designing Bioactive molecules Three dimensional Techniques and applications , Edited by Yvonne C.
Martin and Peter Willett.(2009)
6- Burger's medicinal chemistry and drug discovery Edited by Manfred E.wolff(2006)
7- Scientific papers
B- Recommended books, materials, and media:
1- An Introduction To Drug Synthesis, Edited by, Graham L. Patrick (2015)
2- An Introduction To Medicinal Chemistry, 5th Edition, Edited by Graham L. Patrick
3- The organic chemistry of drug design and drug action ,third edition, Edited by Richard
B.Silverman.(2005)
26. Additional information:
Electronic Databases including Sci Finder; Web of Science; Pubmed; Science direct; etc.......
Name of Course Coordinator: Dr Ghadeer Suaifan Signature: Ghadeer Suaifan Date: 1-9-2015
Head of curriculum committee/Department: ------------------------- Signature: --------------------------------Head of Department: Dr Mayadah Shehadeh
Signature: ---------------------------------
Head of curriculum committee/Faculty: Yasser Bustanji
Signature: ---------------------------------
Dean: ------------------------------------------- -Signature: ---------------------------------
5
The University of Jordan
Course Syllabus
Accreditation and Quality Assurance Center
Copy to:
Head of Department
Assistant Dean for Quality Assurance
Course File
6