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The University of Jordan Accreditation & Quality Assurance Center COURSE Syllabus The University of Jordan Course Syllabus Accreditation and Quality Assurance Center 1 Course title Advanced Organic Chemistry 2 1231722 4 Course number Credit hours (theory, practical) Contact hours (theory, practical) Prerequisites/corequisites 5 Program title Msc Degree in Pharmaceutical Sciences 6 Program code 7 Awarding institution The University of Jordan 8 Faculty Pharmacy 9 Department Pharmaceutical Chemistry 10 Level of course PostgraduateYear 1 11 Year of study and semester (s) 2015/2016 First Semester 12 Final Qualification Other department (s) involved in teaching the course None 14 Language of Instruction English 15 Date of production/revision 01-9-2015 3 13 3 (theory) 3 (theory) 16. Course Coordinator: Dr Ghadeer suaifan Office number: 206 Office Phone Number: 2331 Email: [email protected]/[email protected] Office hours to be announced 17. Other instructors: Dr Mohammad Khanfar Office number: Office Phone Number: 23339 Email: [email protected] Office hours to be announced 18. Course Description: This course includes the common organic reactions (classical and recent) including their generic names, mechanism, reagents, conditions, the required starting materials and their generated products. Advanced synthetic strategies and retro-synthetic analysis, synthesis of complex natural products with biologically 1 The University of Jordan Course Syllabus Accreditation and Quality Assurance Center interesting molecules such as antibiotics, antihypertensive agents, hormones anticoagulants and antiviral agents. 19. Course aims and outcomes: A- Aims: Provide postgraduate master students with a special and advanced education in the field of Pharmaceutical organic chemistry and enable them to gain the skills and attributes required for the responsible practice of Organic chemistry experiments. B- Intended Learning Outcomes (ILOs): Upon successful completion of this course students will be able to … A) Knowledge and understanding: The course would provides students with excellent opportunities to demonstrate knowledge and understanding qualities and develop skills appropriate for the design, synthesis and optimize novel Medicinal Compounds. Knowledge and Understanding : Upon completion of the course, students will be able to: 1-Demonstrate the principles of advanced organic chemistry and its related subjects including fundamentals of organic chemistry of drug synthesis. 2- Contribute to the development of medicinal agents through the optimizing and synthesis of novel drug candidates. 3- Understand up-to-date applications of organic chemistry in drug synthesis. 4- Awareness regarding legal authorities and patency rights 5- Understanding the basics of good laboratory 6- Shows clearly full consciousness of ethics in all aspects of scientific research including novel drug in vivo testing. B) Intellectual Skills: Upon completion of the course, students will be able to: 1- Proper handling of chemical reagents and the assignment of safety sheet. 1-Design possible synthetic pathway of a specific drug candidate and predict the reactions mechanisms. 2- Evaluate the anticipated problems and side reactions that might emerge during the synthesis process. 3- Develop necessary method for drug target purification. 4- Propose of a laboratory schemes for an advanced medicinal drug synthesis. 5- Be a decisions maker in proposing a synthetic scheme based on material availability, safety, cost and experiment time. C) Professional and Practical Skills: Upon completion of the course, students will be able to: 1- Apply professional skills in synthesis and evaluation of different pharmaceutical organic compounds. 2- Put in writing and discuss the target compound synthetic pathway, proposed mechanism of the reactions in the form of thesis and scientific papers. 3- Pick up and apply the proper techniques and precaution during the practical work in the lab D) General and Transferable Skills: Upon completion of the course, students will be able to: 1- Interact effectively with professionals. 2- Search scientific resources to find out the proper scientific materials. 3- Pursuit self estimation in drug synthesis for personal learning needs. 4- Restore information in the field of advanced organic chemistry from different sources. 2 The University of Jordan Course Syllabus Accreditation and Quality Assurance Center 5- Apply standards for judging on the performance of other colleagues. 6- Initiate and activate team work. 7- Coordinate and manage research time to get goals. 8- Be an independent learner. Program Competencies Achieved: 3.1 Identify physiochemical properties of drug substances. 3.11 Identify analytical method development and validation used in pharmaceutical Analysis. 7.4 Follow new advances in science related to the profession. 7.5 Utilize information technology tools to enhance working experience 20. Topic Outline and Schedule: Topic Week Introduction to Advanced Organic chemistry * Structure and Mechanism *Reactions and Synthesis *Reaction of alcohol and phenol * Reaction of carbonyl compounds. * Reaction of alkyl halide * Organometalic reaction *Reaction of ether, epoxides and ethers * Reaction of amine, amide * Oxidation reduction ladder *Enzyme Catalyzed Reaction * Others Mid term Exam Heterocyclic Organic Chemistry Retro synthesis and examples on Medicinal drugs Synthesis of different Medicinal Drug Final Exam 1 Dr Ghadeer Suaifan A1-3, B1, C1 2-3 Dr Ghadeer Suaifan Dr Ghadeer Suaifan A1-3, B1, C1 Dr Ghadeer Suaifan Dr Ghadeer Suaifan A1-3, B1, C1 Dr Ghadeer Suaifan A1-3, B1, C1 3 4-7 8 9-10 11-14 15 16 Instructor Achieved ILOs A1-3, B1, C1 A1-3, B1, C1 Evaluatio n Methods Written Exam Reference 1,2,3 Written Exam Written Exam and Seminars 1,2,3 Written Exam Written Exam 1,2,3 Seminars 1,2,3 1,2,3 1,2,3 The University of Jordan Course Syllabus Accreditation and Quality Assurance Center 21. Teaching Methods and Assignments: Development of ILOs is promoted through the following teaching and learning methods: Power point presentations, activity workshops, watching videos and lab visiting ILO/s Learning Methods Evaluation Methods A1-3, B1, C1 D1 Lectures Exams Assignment Seminars 1. 2. 3. 4. Critical thinking Scientific reasoning Problem-solving skills Self-directed learning 22. Evaluation Methods and Course Requirements: Opportunities to demonstrate achievement of the ILOs are provided through the following assessment methods and requirements: Written Exam, Seminars, activity workshops, organic laboratory visit, follow up and oral presentations. 23. Course Policies: A- Attendance policies: Students’ attendance must comply with the regulations of The University of Jordan. However, students are recommended to attend all lectures to fulfil the course purpose B- Absences from exams and handing in assignments on time: C- Health and safety procedures: D- Honesty policy regarding cheating, plagiarism, misbehavior: E- Grading policy: Students will fail if they get below 60%. Grade Scale A*, A, B+, B, B-, ........... F- Available university services that support achievement in the course: Course evaluation report will be distributed to students by the end of the course to permit self evaluation. Also, statistical analysis will be held to find out students achievement based on students written exam and oral presentations results. 24. Required equipment: Data Show, White board, Computer, Audio system, Organic chemistry lab. 4 The University of Jordan Course Syllabus Accreditation and Quality Assurance Center 25. References: A- Required book (s), assigned reading and audio-visuals: 1234- Organic Chemistry 9th Edition, Edited by John E. Mc Murry (2015) An Introduction To Drug Synthesis, Edited by, Graham L. Patrick (2015) An Introduction To Medicinal Chemistry, 5th Edition, Edited by Graham L. Patrick The organic chemistry of drug design and drug action ,third edition, Edited by Richard B. Silverman.(2005) 5- Designing Bioactive molecules Three dimensional Techniques and applications , Edited by Yvonne C. Martin and Peter Willett.(2009) 6- Burger's medicinal chemistry and drug discovery Edited by Manfred E.wolff(2006) 7- Scientific papers B- Recommended books, materials, and media: 1- An Introduction To Drug Synthesis, Edited by, Graham L. Patrick (2015) 2- An Introduction To Medicinal Chemistry, 5th Edition, Edited by Graham L. Patrick 3- The organic chemistry of drug design and drug action ,third edition, Edited by Richard B.Silverman.(2005) 26. Additional information: Electronic Databases including Sci Finder; Web of Science; Pubmed; Science direct; etc....... Name of Course Coordinator: Dr Ghadeer Suaifan Signature: Ghadeer Suaifan Date: 1-9-2015 Head of curriculum committee/Department: ------------------------- Signature: --------------------------------Head of Department: Dr Mayadah Shehadeh Signature: --------------------------------- Head of curriculum committee/Faculty: Yasser Bustanji Signature: --------------------------------- Dean: ------------------------------------------- -Signature: --------------------------------- 5 The University of Jordan Course Syllabus Accreditation and Quality Assurance Center Copy to: Head of Department Assistant Dean for Quality Assurance Course File 6