Research in our group encompasses the following 4 areas in
... monoarylation by allylic substitution and subsequent site-selective second arylation by directed allylic C-H activation giving stereoselectively anti--(aryl,styryl)-β-hydroxy acids. Presence of O2 was crucial for the second arylation via Pd(II) catalysis. ...
... monoarylation by allylic substitution and subsequent site-selective second arylation by directed allylic C-H activation giving stereoselectively anti--(aryl,styryl)-β-hydroxy acids. Presence of O2 was crucial for the second arylation via Pd(II) catalysis. ...
File
... Explain how the reaction in part (f) (i) occurs by drawing the mechanism, using curly arrows to represent the movement of electron pairs and identify the two ...
... Explain how the reaction in part (f) (i) occurs by drawing the mechanism, using curly arrows to represent the movement of electron pairs and identify the two ...
Chem 342 Jasperse Syllabus 1 Organic Chemistry II READING
... What’s Covered in Organic I versus Organic II differs between NDSU and MSUM The following are reading sections and problems associated with one chapter that was covered at MSUM in Organic I but is covered at NDSU in Organic II. Thus, if you are an NDSU student taking Organic II at MSUM, you will end ...
... What’s Covered in Organic I versus Organic II differs between NDSU and MSUM The following are reading sections and problems associated with one chapter that was covered at MSUM in Organic I but is covered at NDSU in Organic II. Thus, if you are an NDSU student taking Organic II at MSUM, you will end ...
Discussion Sheet 11
... Skill 3: Reactions of alcohols are key C-C bond forming steps in multistep synthesis ...
... Skill 3: Reactions of alcohols are key C-C bond forming steps in multistep synthesis ...
Topic 16 Test - A
... How many structural isomers, which are aldehydes, have the molecular formula C5H10O? A ...
... How many structural isomers, which are aldehydes, have the molecular formula C5H10O? A ...
Unit 8 Homework Packet
... 23. The text explains that one reason why the actual yield for a reaction may be less than the theoretical yield is side reactions. Suggest some other reasons why the percent yield for a reaction might not be 100%. ...
... 23. The text explains that one reason why the actual yield for a reaction may be less than the theoretical yield is side reactions. Suggest some other reasons why the percent yield for a reaction might not be 100%. ...
alcohol - Portal UniMAP
... Use different reducing agents and again these have different strengths. Sodium borohydrate (NaBH4) and Lithium ...
... Use different reducing agents and again these have different strengths. Sodium borohydrate (NaBH4) and Lithium ...
WRL0437.tmp
... Alkyl halides are most commonly synthesized from alcohols by replacing the hydroxyl group with a halide substituent. This is an example of nucleophilic aliphatic substitution, which is part of a very important group of reactions. The overall reaction is the same, but the mechanism varies depending o ...
... Alkyl halides are most commonly synthesized from alcohols by replacing the hydroxyl group with a halide substituent. This is an example of nucleophilic aliphatic substitution, which is part of a very important group of reactions. The overall reaction is the same, but the mechanism varies depending o ...
... evaporation of the solvent under vacuum afforded the formation of the solid fused three membered ring of acridinedione derivatives 3a-c in an excellent yield (80% -92%) see scheme 1. The X-ray crystal structure analysis of 3a-c was carried out (see figures 1,2 and 3 in experimental section). It clea ...
CHEM 263 (AS 40) Organic Chemistry II Winter 2017 Instructor: Dr
... post-secondary institute cannot be used as a prerequisite until assessed and approved for transfer credit. ...
... post-secondary institute cannot be used as a prerequisite until assessed and approved for transfer credit. ...
Grant MacEwan College - Faculty Web Pages
... amines, carboxylic acids, and carboxylic acid derivatives. Illustration of these functional groups in natural products is provided. The application of spectroscopic methods for structural determination in simple molecules is discussed. Prerequisite: Minimum grade of C- in CHEM 161 or 261 The Faculty ...
... amines, carboxylic acids, and carboxylic acid derivatives. Illustration of these functional groups in natural products is provided. The application of spectroscopic methods for structural determination in simple molecules is discussed. Prerequisite: Minimum grade of C- in CHEM 161 or 261 The Faculty ...
Chemdraw B&W - Pennsylvania State University
... • 1,4-dibromobutane reacts twice, giving a cyclic product • Three-, four-, five-, and six-membered rings can be prepared in this way ...
... • 1,4-dibromobutane reacts twice, giving a cyclic product • Three-, four-, five-, and six-membered rings can be prepared in this way ...
this PDF file
... corresponding carbonyl compound was accomplished by the procedure reported in earlier papers. [9, 10]. The above procedure may be carried out on 1-100 g scales without any problem. RESULTS AND DISCUSSION TMAFC was used for the oxidation of some alcohols and polycyclic arenes under microwave irradiat ...
... corresponding carbonyl compound was accomplished by the procedure reported in earlier papers. [9, 10]. The above procedure may be carried out on 1-100 g scales without any problem. RESULTS AND DISCUSSION TMAFC was used for the oxidation of some alcohols and polycyclic arenes under microwave irradiat ...
14. The Direct and Enantioselective Organocatalytic -Oxidation of Aldehydes
... nitrogen atom should partition the addition toward the desired, O-addition manifold. Direct formation of highly versatile aldehyde products without preactivation via an enol derivative is attractive from operational, atom-9 and step-economy standpoints. Moreover, the facile conversion to terminal 1, ...
... nitrogen atom should partition the addition toward the desired, O-addition manifold. Direct formation of highly versatile aldehyde products without preactivation via an enol derivative is attractive from operational, atom-9 and step-economy standpoints. Moreover, the facile conversion to terminal 1, ...
Microwave-Assisted Esterification of N -Acetyl-L-Phenylalanine Using Modified Mukaiyama s Reagents: A New Approach Involving Ionic Liquids
... In addition, amides may be produced in the absence of N-protection [15]. Therefore, in this study, we used N-acetyl-L-phenylalanine (L-3) as a model compound. As illustrated in Scheme 3, the Mukaiyama’s reaction is generally considered as a two-step strategy [16-17]: (1) a nucleophilic aromatic subs ...
... In addition, amides may be produced in the absence of N-protection [15]. Therefore, in this study, we used N-acetyl-L-phenylalanine (L-3) as a model compound. As illustrated in Scheme 3, the Mukaiyama’s reaction is generally considered as a two-step strategy [16-17]: (1) a nucleophilic aromatic subs ...
Stereoselective Reduction of Ketones with Sodium Borohydride
... – The carbon atoms is nuclophilic – Widely used to make new carbon-carbon bonds – Used to attach carbonyl groups of aldehydes, ketones, and ...
... – The carbon atoms is nuclophilic – Widely used to make new carbon-carbon bonds – Used to attach carbonyl groups of aldehydes, ketones, and ...
103. Oxalates as Activating Groups for Alcohols in Visible Light Photoredox Catalysis: Formation of Quaternary Centers by Redox-Neutral Fragment Coupling
... because N-phthalimidoyl oxalates are not stable to aqueous workup or flash chromatography. As such, identifying an activating group for tertiary alcohols that is both stable and capable of generating and coupling radicals in a redox-neutral fashion (i.e., without the need for supplementary reductants ...
... because N-phthalimidoyl oxalates are not stable to aqueous workup or flash chromatography. As such, identifying an activating group for tertiary alcohols that is both stable and capable of generating and coupling radicals in a redox-neutral fashion (i.e., without the need for supplementary reductants ...
In Situ Click Chemistry
... In situ AA Click chemistry is completely biocompatible, uses irreversible reaction to unite reagents inside the protein´s binding ...
... In situ AA Click chemistry is completely biocompatible, uses irreversible reaction to unite reagents inside the protein´s binding ...
ppt
... (The workhorse of ether syntheses) Reaction of an alkoxide with an alkyl halide or tosylate to give an ether. Alkoxides are prepared by the reaction of an alcohol with a strong base such as sodium hydride (NaH) ...
... (The workhorse of ether syntheses) Reaction of an alkoxide with an alkyl halide or tosylate to give an ether. Alkoxides are prepared by the reaction of an alcohol with a strong base such as sodium hydride (NaH) ...
1. Four of the structural isomers of C4H10O are alcohols. One of
... Aluminium is manufactured by electrolysis of a solution of aluminium oxide in molten ...
... Aluminium is manufactured by electrolysis of a solution of aluminium oxide in molten ...
Discodermolide
(+)-Discodermolide is a polyketide natural product found to stabilize microtubule. (+)-discodermolide was isolated by Gunasekera and his co-workers at the Harbor Branch Oceanographic Institute from the deep-sea sponge Discodermia dissoluta in 1990. (+)-Discodermolide was found to be a potent inhibitor of tumor cell growth in several MDR cancer cell lines. (+)-discodermolide also shows some unique characters, including a linear backbone structure, immunosuppressive properties both in vitro and in vivo, potent induction of an accelerated senescence phenotype, and synergistic antiproliferative activity in combination with paclitaxel. Discodermolide was recognized as one of the most potent natural promoters of tubulin assembly. A large number of efforts toward the total synthesis of (+)-discodermolide were directed by its interesting biological activities and extreme scarcity of natural sources (0.002% w/w from frozen marine sponge). The compound supply necessary for complete clinical trials cannot be met by harvesting, isolation, and purification. As of 2005, attempts at synthesis or semi-synthesis by fermentation have proven unsuccessful. As a result, all discodermolide used in preclinical studies and clinical trials has come from large-scale total synthesis.