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Peripheral Nervous System (PNS) PNS – all neural structures
Peripheral Nervous System (PNS) PNS – all neural structures

... Nerve – cordlike organ of the PNS consisting of peripheral axons enclosed by connective tissue ...
REM-off
REM-off

... ‘functional anatomy’ – Even when the strength of a synaptic connection between two neurons is stable (i.e., release of transmitter by the presynaptic neuron opens the same number and type of ionotropic receptors on the postsynaptic neuron), the impact of the presynaptic neuron on the postsynaptic n ...
EN Sokolov`s Neural Model of Stimuli as Neuro
EN Sokolov`s Neural Model of Stimuli as Neuro

... humorally or synaptically. Serotonergic neurons have been found, the stimulation of which causes an increase in EPSP command (motor) neurons implementing the reflex. These neurons facilitate synaptic response to the conditioned stimulus, often called "reinforcing" or modulating one. Thus, it is assu ...
Detecting Action Potentials in Neuronal Populations with Calcium
Detecting Action Potentials in Neuronal Populations with Calcium

... a complete understanding of the circuit activation patterns. An alternative approach to characterize circuit dynamics is optical recording from neuronal populations (9). The optical nature of the experiment permits simultaneous recording from many neurons, makes the technique noninvasive, and gives ...
Reinforcement, and Punishment Striatal Mechanisms Underlying
Reinforcement, and Punishment Striatal Mechanisms Underlying

... selectively expressed by direct pathway neurons, and the dopamine Drd2 receptor, which is selectively expressed by indirect pathway neurons. Due to this differential expression, dopamine affects the neurons of each pathway differently (63). The dopamine Drd1 receptor is coupled to G␣s, which activat ...
Connexionism and Computationalism
Connexionism and Computationalism

... Let’s revisit Newell and Simons “General Problem Solver” which we explored through the “blocks problem”, where starting from a single black block (the axiom) and a series of production rules we generated a series of patterns (theorems) by the application of each rule, and chose the theorem which was ...
Introduction to Psychology
Introduction to Psychology

... f) Explain why the brain depends so heavily on glucose as a fuel. ...
Objectives
Objectives

... c) Describe the effects of MDMA on the brain and on behavior. d) Describe the effects of nicotine on the brain. e) Identify three types of opiates and describe their effects on behavior. f) Summarize the findings of Pert & Snyder. g) Discuss the medical uses and psychological effects of marijuana. h ...
Gee JNeuro 2012 - Stanford University
Gee JNeuro 2012 - Stanford University

... V pyramidal neurons that have thick apical tufts, prominent h-current, and subcortical projections. Within this subpopulation, the D2R agonist quinpirole elicits a novel afterdepolarization that generates voltage fluctuations and spiking for hundreds of milliseconds. Surprisingly, this afterdepolari ...
Autonomic Nervous System
Autonomic Nervous System

... They exit from the Lateral horn of the spinal cord. Most sympathetic nerve fibers separate from somatic motor fibers and synapse with postganglionic neurons ...
Hippocampus, hippocampal sclerosis and epilepsy
Hippocampus, hippocampal sclerosis and epilepsy

... tion by “latent (dormant)” GABA interneurons of bioelectrical activity of the principal neurons. The “latency” of these interneurons is due to the lack of their physiological stimulation by damaged hilar mossy cells [88]. In addition to neuronal degeneration and gliosis, the so called mossy fiber sp ...
Evolution of the Insulin Receptor Family and
Evolution of the Insulin Receptor Family and

... mannose-6-phosphate receptor that, only in mammals, has acquired a binding domain for IGF2, and it is not a signaling receptor (Morgan et al. 1987). In addition, an orphan receptor (with an unknown ligand) termed the insulin receptor-related receptor (IRR) was also described as a member of the IR fa ...
Dopamine – CNS Pathways and Neurophysiology
Dopamine – CNS Pathways and Neurophysiology

... is overcome by a change in firing pattern from singlespike firing to burst firing. Burst firing in DA neurons induces increases in DA release that are 2–3 times that of increases in tonic firing rates of the same magnitude. Moreover, DA released during burst firing has been demonstrated to be locali ...
Chapter 15 the autonomic nervous system -
Chapter 15 the autonomic nervous system -

... III = oculomotor – lens and pupil, ciliary muscles, pupillary constrictors through ciliary ganglion VII = facial – tears, salivary, nasal glands (submandibular ganglion) IX = glossopharyngeal – tympanic nerve, otic ganglion, parotid glands X = vagus – 90% of all parasympathetic preganglion fibers ...
Artificial Intelligence
Artificial Intelligence

... to the network is processed by the entire network and an output (or multiple outputs) produced. • There is no central processing or control mechanism, the entire network is involved in every piece of computation that takes place. ...
Chapter 2: Communication Within the Nervous System
Chapter 2: Communication Within the Nervous System

... adventure of biological psychology. There are other good texts out there, but they read like they were written for serious junior and senior psychology majors who appreciate the importance of biological psychology in its own right. This book is for them, too, but I wrote it so any student who is int ...
Chapter 15 the autonomic nervous system -
Chapter 15 the autonomic nervous system -

... III = oculomotor – lens and pupil, ciliary muscles, pupillary constrictors through ciliary ganglion VII = facial – tears, salivary, nasal glands (submandibular ganglion) IX = glossopharyngeal – tympanic nerve, otic ganglion, parotid glands X = vagus – 90% of all parasympathetic preganglion fibers ...
Dialene 4—Fat Loss You Can FEEL!
Dialene 4—Fat Loss You Can FEEL!

... which degrades to pyruvate to be oxidized for ATP in the citric acid cycle. The H+ are accepted by NAD+ and sent to the electron transport chain. Glycerol also has a gluconeogenic role as it provides carbon skeletons for glucose synthesis. When glycogen levels are low or depleted, glycerol can serve ...
patrick_ch19_p3
patrick_ch19_p3

... Quaternary N is added to bind to the anionic region Side chain is designed to place the hydroxylamine moiety in the correct position relative to phosphorylated serine Pralidoxime 1 million times more effective than hydroxylamine Cannot act in CNS due to charge - cannot cross bbb ...
fluctuations in somatosensory responsiveness and baseline firing
fluctuations in somatosensory responsiveness and baseline firing

... sensory striatal neurons of SNr-intralaminar thalamic-striatal projections that may have been altered by intranigral APO injection. At the same time, an APO influence on SNr neurons could partially explain some motoric disturbances observed, i.e. via altered SNr transmission to motor thalamo-cortica ...
reward and reinforcement i
reward and reinforcement i

... A variety of data, both in animals and humans, implicate an involvement of dopamine (DA) in the positive reinforcement process, especially in relation to the mesocorticolimbic DA system, and the nucleus accumbens in particular. Recall from your study of Parkinson’s disease that the caudate and putam ...
extrasynaptic glutamate does not reach the postsynaptic density
extrasynaptic glutamate does not reach the postsynaptic density

... et al. [20], ACPD, selective agonist of certain subtypes of these receptors, inhibited population spike in CA1 (but not in CA3) neurons leaving the EPSC unaffected. The age of the animals is critical for this phenomenology. In the rats younger than P20, ACPD inhibits EPSCs as well. This action is me ...
Amyloid inhibits retinoic acid synthesis exacerbating Alzheimer
Amyloid inhibits retinoic acid synthesis exacerbating Alzheimer

... NEP activity assay was done following previous methods (Tamboli et al., 2010). NEP substrate was N-succinyl-Ala-Ala-Phe-7amido-4-methylcoumarin (Sigma Aldrich) and NEP inhibitor thiorphan (Sigma Aldrich). For TNFa and Ab42 quantification, a mouse TNFa ELISA Kit (Molecular Probes, Invitrogen) and a hu ...
Monocyte chemoattrac- tant protein
Monocyte chemoattrac- tant protein

... lpr mice has been reported to be upregulated (10, 11), and MCP-1 may also be responsible for inflammation in nephritis (12). In addition, the fact that MCP-1 deficiency resulted in the improvement of glomerulonephritis in MRL lpr mice (13) and that treatment with a MCP-1 antagonist results in reduct ...
03&04 ANS LECTURE Sultan Ayoub Meo Sept 2 2012
03&04 ANS LECTURE Sultan Ayoub Meo Sept 2 2012

... sphincters and metabolic changes such as the mobilisation of fat and glycogen. ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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