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Unit One: Introduction to Physiology: The Cell and General
Unit One: Introduction to Physiology: The Cell and General

... Direct Chemical Control of the Respiratory Center a. The dorsal, ventral, and pneumotaxic centers are not affected by carbon dioxide or hydrogen ion levels b. The chemosensitive area is highly sensitive to changes in PCO2 and hydrogen ion concentrations c. Excitation by hydrogen ions is the primary ...
Kaan Yücel M.D., Ph.D. http://fhs122.org
Kaan Yücel M.D., Ph.D. http://fhs122.org

... connective tissue cells of the nervous system. The neurons have te feature of excitability. The neuroglia do not have this feature. The neuroglia are known as macroglia, ependymal cells and microglia. The microglia are the macrophages of the nervous system. 1- They serve as supporting elements. They ...
Neurons - LPS.org
Neurons - LPS.org

... and their receptor cells to gather and transform information into a form your brain can understand. The sense organs are not actually located in the brain, so your neural system must literally move the information your receptor cells pull in. This movement occurs as billions of neurotransmitter mole ...
Co-activation of VTA DA and GABA neurons mediates nicotine
Co-activation of VTA DA and GABA neurons mediates nicotine

... systems,10 but none of them has yet elucidated the nature of their interaction, that is, whether they cooperate to produce the rewarding effect,9,11,12 or mediate, respectively, the acute rewarding and aversive psychological effects of nicotine.10 The complexity of nicotine’s action to result in enh ...
Hypothesized Deficiency of Guanine
Hypothesized Deficiency of Guanine

Receptores Monoaminérgicos en Corteza Prefrontal: Mecanismo de Acción de Fármacos Antipsicóticos
Receptores Monoaminérgicos en Corteza Prefrontal: Mecanismo de Acción de Fármacos Antipsicóticos

... antagonist phencyclidine (PCP) on PFC function to understand the cellular and network elements involved in its schizomimeitc actions. PCP induces a marked disruption of the activity of the PFC in the rat, increasing and decreasing the activity of 45% and 33% of the pyramidal neurons recorded, respec ...
L3-ANS LECTURE Sulta..
L3-ANS LECTURE Sulta..

... sphincters and metabolic changes such as the mobilisation of fat and glycogen. ...
5104-c2
5104-c2

... • Using paired whole-cell recordings, we have found that many neurons in the rat SCN communicate via electrical synapses. Spontaneous spiking was often synchronized in pairs of electrically coupled neurons, and the degree of this synchrony could be predicted from the magnitude of coupling. • In wild ...
Alcohol and neuroinflammation: Involvement of astroglial cells and
Alcohol and neuroinflammation: Involvement of astroglial cells and

... The central nervous system (CNS) was considered as an immune privileged organ, which was not susceptible to inflammation or immune activation, and was thought to be largely unaffected by systematic inflammatory and immune responses. This point of view has changed drastically during the last decade. ...
Trigeminal pathways PP
Trigeminal pathways PP

... Outline the two pathways for facial sensation from the head. ...
Motor pathways - autonomic Nervous system
Motor pathways - autonomic Nervous system

... Autonomic Nervous System (ANS) function  The ANS major function is to maintain homeostasis  The ANS :  functions via visceral (subconscious) reflexes  The autonomic system is coordinated primarily by the hypothalamus and the medulla (higher centers)  The brain stem and the spinal cord seem to ...
Muscles
Muscles

... • Botulinum toxin is produced by bacterium Clostridium botulinum. The toxin is a two-chain polypeptide with a heavy chain joined by a disulphide bond to a light chain. • The light chain is a protease that attacks one of the fusion proteins at a neuromuscular junction, preventing vesicles from anchor ...
Theramine™ Product Information
Theramine™ Product Information

... hemoglobin; however, there is no evidence of histidine de novo synthesis in mammalian tissues and therefore an exogenous supply is important during times of increased needs to preserve muscle mass and plasma hemoglobin concentration. In contrast to the amino acids which are nonessential under normal ...
Objectives 35 - U
Objectives 35 - U

... of the desired movement (integrates motivation and ideas about responses) - all basal ganglia disorders affect cognitive or emotion function to varying degrees; depression, dementia (Huntington’s) and cognitive changes (Parkinson’s) - a limbic loop exists through basal ganglia; limbic structures  p ...
Parts of the nervous system
Parts of the nervous system

... chemicals from the burning rag. 7 B. The nerve impulse travels from one neuron to another until it reaches the spinal cord. 6 C. The brain interprets the message as ”a rag is burning”. 8 D. The motor neurons send a message to the leg and arm muscles. 1/2 E. The sensory receptors in the boy’s eyes ar ...
Do distinct populations of dorsal root ganglion neurons account for
Do distinct populations of dorsal root ganglion neurons account for

... e.g., in the kidney occur. It is widely accepted that tissue injury, inflammation, and ischemia are accompanied by local tissue acidosis (16), and TRPV1 (29) as well as members of the acid-sensing ion channels (ASIC) family (8, 42) have been described as putative transducers of peptidergic afferent ...
RESOURCE - Synthetic Neurobiology Group
RESOURCE - Synthetic Neurobiology Group

... the activities of specific cell types and to examine the resulting effects. A recent innovation in experimental neuroscience has been the development of light-activated channels or pumps, derived from microbial photosynthetic systems, to modulate neural activity, known as opto­ genetics. The best-kn ...
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria
Brain Uncoupling Protein 2: Uncoupled Neuronal Mitochondria

... producing orexin, melanin-concentrating hormone, and luteinizing hormone-releasing hormone. When c-fos-expressing cells were analyzed in the basal brain after either fasting or cold exposure, it was found that all activated neurons received a robust UCP2 input on their perikarya and proximal dendrit ...
Chemical-Scale Studies of the Phe-Pro Conserved Motif in the Cys
Chemical-Scale Studies of the Phe-Pro Conserved Motif in the Cys

... The Cys-loop superfamily of neurotransmitter-gated ion channels includes the nicotinic acetylcholine receptor (nAChR)2, the 5-HT3 serotonin receptor, the GABAA and GABAC receptors, and the glycine receptor (1, 2). Together, these receptors mediate both excitatory and inhibitory fast synaptic transmi ...
Viral vector-based tools advance knowledge of basal ganglia
Viral vector-based tools advance knowledge of basal ganglia

... (Alexander et al. 1986; Bolam et al. 2000; Galvan et al. 2015) (Fig. 1B). Here, the NAc is the major input nucleus, receiving glutamatergic input from the prefrontal cortex (PFC), hippocampus, and amygdala and dopaminergic innervation from the VTA (Russo and Nestler 2013). It also receives serotoner ...
Nervous System
Nervous System

... chemical and electrical forces acting on a specific ion across the cell membrane ...
Pain
Pain

... •Acupuncture has been practiced in China for more than 4000 years as a method for pain relief. ...
Memory Extinction, Learning Anew, and Learning the New
Memory Extinction, Learning Anew, and Learning the New

... of long-term memory of CTA to a familiar taste. Thus, memory extinction shares molecular mechanisms with learning, but the mechanisms of learning anew differ from those of learning the new. Experimental extinction is the decline in the frequency or intensity of a conditioned response following the w ...
Unit – M Neuron, Impulse Generation, and Reflex Arc Structures and
Unit – M Neuron, Impulse Generation, and Reflex Arc Structures and

... When the axon or dendrite is stimulated, sodium gates open which allows some Na+ to enter the axoplasm (interior). Now, the inside becomes more positive than the outside by 40 mv. This is called the Upswing Phase of the action potential. The charge changes from –60 mv to +40 mv. The change is calle ...
HOMOLOGY MODELING OF ARYL HYDROCARBON RECEPTOR AND DOCKING OF AGONISTS
HOMOLOGY MODELING OF ARYL HYDROCARBON RECEPTOR AND DOCKING OF AGONISTS

... (bHLH) PAS family[1-5]. It is a nuclear receptor, located in the cytoplasm and exists as one component of the complex[6]; the other components being two molecules of heat shock protein (hsp90), an X-associated protein and a co-chaperone protein[7]. When agonists bind to the receptor, hsp90 dissociat ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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