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Hayrunnisa Bolay, Turkey
Hayrunnisa Bolay, Turkey

... is a key to understand familial hemiplegic migraine phenotype, critical involvement of glutamatergic synapse, female hormonal influence and the efficacy of preventive anti-migraine drugs. Animal studies investigating the mechanisms of migraine and CSD are commonly conducted under anesthesia, despite ...
Human Anatomy Unit 6 – Chapter 8 – Nervous System Work List
Human Anatomy Unit 6 – Chapter 8 – Nervous System Work List

... The location at which a neuron can transfer an impulse to another cell is called a synapse (SIN-aps). A space, called the synaptic cleft, separates the axon terminal from the dendrites of the adjacent cell, in this case a neuron. The terminals contain tiny sacs, or vesicles, filled with neurotransmi ...
the role of prostanoids in the urinary bladder function and a potential
the role of prostanoids in the urinary bladder function and a potential

... muscles, blood cells but except red blood cells) and it is a source of ñ so called ñ housekeeping prostanoids, involved in numerous physiological functions, preserving homeostasis of most systems. COX-2 level is low in normal tissues but it becomes induced by inflammatory stimuli as well as hormones ...
Drivers and modulators from push-pull and balanced synaptic input
Drivers and modulators from push-pull and balanced synaptic input

... carried by fast ionotropic receptors, whereas modulators correspond to slower metabotropic receptors. Instead, we have proposed a novel mechanism by which both driver and modulator inputs could be carried by transmission through the same types of ionotropic receptors. In this scheme, the distinction ...
Forebrain glutamatergic neurons mediate leptin action on
Forebrain glutamatergic neurons mediate leptin action on

... studies have found an association between low levels of leptin and major depressive disorders.25–27 Of note, a recent study by Lawson et al.28 reported an inverse correlation between leptin levels and the severity of depression symptoms. These correlational studies suggest that leptin signaling may ...
chapt12_lecturenew
chapt12_lecturenew

... – form a supportive framework of nervous tissue – have extensions (perivascular feet) that contact blood capillaries that stimulate them to form a tight seal called the blood-brain barrier – convert blood glucose to lactate and supply this to the neurons for nourishment – nerve growth factors secret ...
The Role of Dorsal Columns Pathway in Visceral Pain
The Role of Dorsal Columns Pathway in Visceral Pain

... supraspinal sites, as it was not affected by decerebration but it could not be evoked after spinalization (Ness and Gebhart 1988). It was shown previously that responses of spinal neurons to visceral stimuli are under strong descending facilitatory control (Cervero and Wolstencroft 1984, Tattersall ...
galanin - Personal Home Pages (at UEL)
galanin - Personal Home Pages (at UEL)

... •Galanin is widely distributed in both the central and the peripheral nervous systems. •In the CNS: hypothalamus/hippocampus, brain stem, spinal cord. •In the peripheral organs: pancreas, adrenal gland, gastrointestinal tract, genital tract, urinary bladder ...
Pain bare
Pain bare

... • found in skin, mucous membranes • fire immediately on stimulation, stop when stimulus removed • produce sharp pain (eg. getting injection), well localised ...
MSH-induced inhibition of oxytocin cells
MSH-induced inhibition of oxytocin cells

... and peristimulus time histograms (PSTH) were constructed to quantify the responses. For each cell, the responses to trains were analyzed by constructing PSTHs for 1,000 s (200 trains, 250 bins of 20 ms) in control conditions and during and after drug application by retrodialysis to the SON. The PSTH ...
Nerve Fiber Classification Nerve fibers are classified according to:
Nerve Fiber Classification Nerve fibers are classified according to:

... Spatial summation – postsynaptic neuron is stimulated by a large number of terminals at the same time (usually from different neurons) ...
Seizure, neurotransmitter release, and gene expression are closely
Seizure, neurotransmitter release, and gene expression are closely

... acid and aspartic acid take part in the induction, maintenance, and propagation of seizures and mediate some of the neuropathological effects of neuronal hyperactivity (Sloviter and Dempster, 1985; Peña and Tapia, 2000). Glutamate (GLU) and aspartate (ASP) are epileptogenic and excitotoxic to nerve ...
NIPS/Dec99/notebook3
NIPS/Dec99/notebook3

... The corticonuclear pathway has at least two components, 1) corticonuclear cells whose axons do not reach the spinal cord and 2) corticospinal cells projecting mainly to cervical segments and whose axons send collateral branches into the DCN (2, 12). Therefore, corticospinal fibers sending collateral ...
M100,907, a selective 5-HT antagonist, attenuates dopamine
M100,907, a selective 5-HT antagonist, attenuates dopamine

... Previous research has suggested that serotonin 5-HT 2A receptors modulate the functioning of the mesocortical dopamine (DA) pathway. However, the specific role of 5-HT 2A receptors localized within the medial prefrontal cortex (mPFC) is not known. The present study employed in vivo microdialysis to ...
Stored Triglycerides (Fat)
Stored Triglycerides (Fat)

... degraded into acetyl-CoA molecules, they are sent into the citric acid cycle. ATP (the body’s main energy source) phosphorylates this reaction, then water is added, and the H+ are passed to NAD+ and FAD to be sent to the respiratory chain to be oxidized to create more ATP. Beta-Oxidation is an aerob ...
Autonomic Nervous System
Autonomic Nervous System

... • Increases metabolic rates of cells • Raises blood glucose levels • Mobilizes fats for use as fuels ...
New insights into the roles of microRNAs in drug addiction and
New insights into the roles of microRNAs in drug addiction and

... abuse modulate gene expression, and produce their rewarding effects of euphoria or pleasure through an interaction with the mesolimbic dopaminergic system, leading to persistent alterations (neuroplastic, structural and functional) in the reward-related and memoryrelated brain centers. An overview o ...
Olfactory processing: maps, time and codes Gilles Laurent
Olfactory processing: maps, time and codes Gilles Laurent

... degree, static, such as a short odor puff. Recent work on olfactory processing in insects from my laboratory [38,39••–41••,42,43] suggests that information about odor identity can indeed be obtained by considering not only the ‘spatial’ component of the response of ensembles of neurons (i.e. which n ...
Immunocytochemical Distribution of the
Immunocytochemical Distribution of the

... 2000). Delta-9-tetrahydrocannabinol (D9-THC), the chief psychoactive cannabinoid in cannabis, has profound effects on mood and a number of cognitive functions (reviewed in Childers and Breivogel 1998; Ameri 1999). In addition, cannabis use has been associated with both an increased risk of, and grea ...
Procainamide4
Procainamide4

... • Highly expressed in liver and intestine • Sequestered in cytoplasm • Co-factor complex required for activation; anchored by PPAR-binding protein (PBP) • Binds response elements as RXR heterodimer ...
Distribution and characterisation of Glucagon-like peptide
Distribution and characterisation of Glucagon-like peptide

Nervous system
Nervous system

... Nerve fibers in Tracts of the CNS are mostly myelinated ( they acquire their myelin from the activities of oligodendrocytes rather than from schwan cells ) . The myelin that surrounds the fibers of tracts gives the tracts a whitish color (thus they are recognized as white matter of the CNS ) . Cell ...
8th Grade Information Processing
8th Grade Information Processing

... Anatomy of the Neuron • Cell Body – with Nucleus • Dendrites- fibers that receive messages from other neurons • Axon- fibers that send messages to other neurons • Myelin sheath- Membrane around the axons ...
Thyroid Gland
Thyroid Gland

... (increase glucose absorption form GIT, Peripheral utilization of glocose, glycolysis in the liver, gluconeogenesis, and uptake of glucose by cells) 3: Effects on protein Metaboloism ( stimulate protein synthesis in ribosomes, normal range it increase protein anabolism while high conc. It causes prot ...
Connections of the Hypothalamus
Connections of the Hypothalamus

... Diagram to show the basic classes of known neural inputs to the visceromotor pattern generator network, along with its major output to neuroendocrine motoneuron pools and preautonomic cell groups, and its generally less massive output to other, nearby brain regions. The HVPG projects directly to neu ...
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Endocannabinoid system

The endocannabinoid system is a group of neuromodulatory lipids and their receptors in the brain that are involved in a variety of physiological processes including appetite, pain-sensation, mood, and memory; it mediates the psychoactive effects of cannabis and, broadly speaking, includes: The endogenous arachidonate-based lipids, anandamide (N-arachidonoylethanolamide, AEA) and 2-arachidonoylglycerol (2-AG); these are known as ""endocannabinoids"" and are physiological ligands for the cannabinoid receptors. Endocannabinoids are all eicosanoids. The enzymes that synthesize and degrade the endocannabinoids, such as fatty acid amide hydrolase or monoacylglycerol lipase. The cannabinoid receptors CB1 and CB2, two G protein-coupled receptors that are located in the central and peripheral nervous systems.The neurons, neural pathways, and other cells where these molecules, enzymes, and one or both cannabinoid receptor types are all colocalized form the endocannabinoid system.The endocannabinoid system has been studied using genetic and pharmacological methods. These studies have revealed that cannabinoids act as neuromodulators for a variety of processes, including motor learning, appetite, and pain sensation, among other cognitive and physical processes. The localization of the CB1 receptor in the endocannabinoid system has a very large degree of overlap with the orexinergic projection system, which mediates many of the same functions, both physical and cognitive. Moreover, CB1 is colocalized on orexin projection neurons in the lateral hypothalamus and many output structures of the orexin system, where the CB1 and orexin receptor 1 (OX1) receptors physically and functionally join together to form the CB1–OX1 receptor heterodimer.
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