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Study of the Immune System
Study of the Immune System

... The 1st introduction of an Ag to the immune system  produces a primary response  gradual increase in Ab titer The 2nd contact with the same Ag  produces a secondary, or anamnestic, response  due to memory cells produced during the initial response ...
Immune System Powerpoint
Immune System Powerpoint

... – White blood cells cannot recognize healthy cells. – White blood cells attack healthy body cells. – Tissues fail because of attack. ...
Immunodeficiencies HIV/AIDS
Immunodeficiencies HIV/AIDS

... exposure, at a time well before anti-HIV Ab’s can be detected. Average time from initial infection to AIDS is about 10 years, though this rate of development is lengthening with new treatments available. ...
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3.3mb

... Natural Killer Cells Function against intracellular pathogens such as viruses ...
File - PBL Group 14
File - PBL Group 14

... 2. Monocytes (differentiate into macrophages)  Largest of the leucocytes  Irregular nucleaus in abundant cytoplasm, containing few vacuoles  Monocytes migrate to the cell where they become macrophages, Kupffer cells or antigen-presenting dendritic cells  They produce a variety of cytokines when ...
Lipoteichoic acid contaminant
Lipoteichoic acid contaminant

... 5.1 Suppressing/Shifting the Immune Response Encoding immunosuppressive proteins in the pathogen’s genome that shift responses from Th1 to Th2, or receptors for cytokines to block their activity: viruses express genes for IL-10 Polyclonal activation of lymphocytes by bacterial mitogens (e.g. LPS). ...
4c * Adaptive Immunity
4c * Adaptive Immunity

... perforin (protein) makes a pore in membrane ions and water enters pores infected cell lyses Remember, involved with “self” ...
Bio 347
Bio 347

Chapter 20 - Dr. Jennifer Capers
Chapter 20 - Dr. Jennifer Capers

Chapter 40: Immune System Chapter 41: Nervous System Chapter
Chapter 40: Immune System Chapter 41: Nervous System Chapter

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What is immunology - British Society for Immunology
What is immunology - British Society for Immunology

... and then migrate to sites of infection where they monitor body cells for signs of intracellular infection or aberrant self proteins associated with cancer – presented on MHC class I molecules – using their TCRs. If they encounter antigen that they recognise, this indicates infection or malignancy, a ...
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What is immunology - British Society for Immunology
What is immunology - British Society for Immunology

... and then migrate to sites of infection where they monitor body cells for signs of intracellular infection or aberrant self proteins associated with cancer – presented on MHC class I molecules – using their TCRs. If they encounter antigen that they recognise, this indicates infection or malignancy, a ...
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ImprovIng Immune response In newborn Calves

... effective vaccine for newborn calves, can be found on the BCRC website at http://www. beefresearch.ca/factsheet.cfm/challenges-todeveloping-an-effective-vaccine-for-newborncalves-39. What it means: This research provided a great deal of knowledge about the complex interactions between various cell t ...
Emotional Behaviors
Emotional Behaviors

... Consists of cells that protect the body against invaders like bacteria and viruses – Leukocytes • White Blood Cells • Patrol blood and other body fluids for invaders • Identifies antigens on intruders and signal attack from immune system – Macrophage • Surrounds intruder, digests it, and exposes its ...
Ch 31 vocabulary list
Ch 31 vocabulary list

... 7. immunity- resistance to a specific pathogen (Concept 31.3) 8. antigen- foreign molecule that provokes an immune response (Concept 31.3) 9. antibody- protein in blood plasma that attaches to a particular antigen (Concept 31.3) 10. B cell- lymphocyte that matures in the bone marrow and later produc ...
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... and then migrate to sites of infection where they monitor body cells for signs of intracellular infection or aberrant self proteins associated with cancer – presented on MHC class I molecules – using their TCRs. If they encounter antigen that they recognise, this indicates infection or malignancy, a ...
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84. Which of the following describes an adjuvant correctly? A An
84. Which of the following describes an adjuvant correctly? A An

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CD4 and HIV

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Innate immunity - Fadel Muhammad Garishah, MD
Innate immunity - Fadel Muhammad Garishah, MD

... substances produced at epithelial surfaces; – (2) phagocytic cells (neutrophils, macrophages) and NK (natural killer) cells; – (3) blood proteins, including members of the complement system and other mediators of inflammation; and – (4) proteins called cytokines that regulate and coordinate many of ...
Immune system - Cloudfront.net
Immune system - Cloudfront.net

... interferon – a protein that defends the body by fighting the infection and stopping viruses lymphatic system –a secondary circulatory system that helps the body fight pathogens and maintain its fluid balance lymphocytes – special white blood cells in the lymph 3 types of lymphocytes: 1. B – in the b ...
Exam #4
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... Know where in the human body lymphocytes come from and where they mature into either B cells or T cells. Focus on helper and cytotoxic T cells, as well as plasma and memory B cells. Which of these lymphocyte types are involved in the cell-mediated versus antibody-mediated (Humeral) immune response. ...
VL 08lecture2008
VL 08lecture2008

... for each pathogen  Effective against both intra- and extracellular pathogens  Two main components: Humoral immunity - Relies on Antibodies produced by B-lymphocytes - Fights pathogens outside of cells ...
What is Immunotherapy?
What is Immunotherapy?

... and eosinophils interact with certain foreign materials. All of the immune cells work together, and need to communicate with each other. They secrete a large number of special protein molecules called cytokines, which act on other cells. There are many different cytokines. Examples of these are inte ...
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Adaptive immune system



The adaptive immune system, also known as the acquired immune or, more rarely, as the specific immune system, is a subsystem of the overall immune system that is composed of highly specialized, systemic cells and processes that eliminate or prevent pathogen growth. The adaptive immune system is one of the two main immunity strategies found in vertebrates (the other being the innate immune system). Adaptive immunity creates immunological memory after an initial response to a specific pathogen, leads to an enhanced response to subsequent encounters with that pathogen. This process of acquired immunity is the basis of vaccination. Like the innate system, the adaptive system includes both humoral immunity components and cell-mediated immunity components.Unlike the innate immune system, the adaptive immune system is highly specific to a specific pathogen. Adaptive immunity can also provide long-lasting protection: for example; someone who recovers from measles is now protected against measles for their lifetime but in other cases it does not provide lifetime protection: for example; chickenpox. The adaptive system response destroys invading pathogens and any toxic molecules they produce. Sometimes the adaptive system is unable to distinguish foreign molecules, the effects of this may be hayfever, asthma or any other allergies. Antigens are any substances that elicit the adaptive immune response. The cells that carry out the adaptive immune response are white blood cells known as lymphocytes. Two main broad classes—antibody responses and cell mediated immune response—are also carried by two different lymphocytes (B cells and T cells). In antibody responses, B cells are activated to secrete antibodies, which are proteins also known as immunoglobulins. Antibodies travel through the bloodstream and bind to the foreign antigen causing it to inactivate, which does not allow the antigen to bind to the host.In acquired immunity, pathogen-specific receptors are ""acquired"" during the lifetime of the organism (whereas in innate immunity pathogen-specific receptors are already encoded in the germline). The acquired response is called ""adaptive"" because it prepares the body's immune system for future challenges (though it can actually also be maladaptive when it results in autoimmunity).The system is highly adaptable because of somatic hypermutation (a process of accelerated somatic mutations), and V(D)J recombination (an irreversible genetic recombination of antigen receptor gene segments). This mechanism allows a small number of genes to generate a vast number of different antigen receptors, which are then uniquely expressed on each individual lymphocyte. Because the gene rearrangement leads to an irreversible change in the DNA of each cell, all progeny (offspring) of that cell inherit genes that encode the same receptor specificity, including the memory B cells and memory T cells that are the keys to long-lived specific immunity.A theoretical framework explaining the workings of the acquired immune system is provided by immune network theory. This theory, which builds on established concepts of clonal selection, is being applied in the search for an HIV vaccine.
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