Differential regulation of lipopolysaccharide and Gram
... monokine induced by IFNγ (MIG). The CC chemokine family includes monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α [11,12]. These cytokines and chemokines contribute to the complex inflammatory milieu of sepsis. However, it remains uncertain to what extent common ...
... monokine induced by IFNγ (MIG). The CC chemokine family includes monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1α [11,12]. These cytokines and chemokines contribute to the complex inflammatory milieu of sepsis. However, it remains uncertain to what extent common ...
Persistent accumulation of interferon-gamma- producing CD8(+)CD56(+) T cells in blood from
... Chronic immune stimulation plays an important role in atherogenesis1. Activated T cells are prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation ...
... Chronic immune stimulation plays an important role in atherogenesis1. Activated T cells are prominent components of human atherosclerotic lesions2-3 and also, blood samples from patients with coronary artery disease (CAD), in particular acute coronary syndromes (ACS), show signs of T cell activation ...
Basophils: new players in the cytokine network
... marrow cells originally named histamine-producing cells that have since been characterized as basophils [10]. Immunologists came to recognize basophils as potential immunoregulatory cells only when it was discovered that they represent one of most potent sources of IL-4 [10-14] and that they can mig ...
... marrow cells originally named histamine-producing cells that have since been characterized as basophils [10]. Immunologists came to recognize basophils as potential immunoregulatory cells only when it was discovered that they represent one of most potent sources of IL-4 [10-14] and that they can mig ...
Harnessing Local Immunity for an Effective Universal Swine
... for the apparent decreased effectiveness of LAIV as compared with the efficacy shown in the original studies is unclear [43], but it could be related to repeated immunisations and increased baseline immunity, which might interfere with vaccine-virus replication [44]. Experimental LAIV vaccines deliv ...
... for the apparent decreased effectiveness of LAIV as compared with the efficacy shown in the original studies is unclear [43], but it could be related to repeated immunisations and increased baseline immunity, which might interfere with vaccine-virus replication [44]. Experimental LAIV vaccines deliv ...
MINI-SERIES ‘‘T-CELL CO-STIMULATORY MOLECULES’’ Edited by M. Belvisi and K.F. Rabe
... ABSTRACT: T-cells play a central role in allergic airway diseases such as bronchial asthma. The imbalance between allergen-specific pro-inflammatory and pro-allergic T-cell responses on one hand and regulatory or suppressive T-cell responses on the other may best explain the development of unwanted ...
... ABSTRACT: T-cells play a central role in allergic airway diseases such as bronchial asthma. The imbalance between allergen-specific pro-inflammatory and pro-allergic T-cell responses on one hand and regulatory or suppressive T-cell responses on the other may best explain the development of unwanted ...
Lymphomas Involving Waldeyer`s Ring
... Although latent Epstein-Barr (EB) viral infection has been a long-standing association, this is true mainly for the endemic form in which all cases harbour the virus, and is rare outside the African continent; the rates of latent EB viral infection in the sporadic and immunodeficiencyassociated form ...
... Although latent Epstein-Barr (EB) viral infection has been a long-standing association, this is true mainly for the endemic form in which all cases harbour the virus, and is rare outside the African continent; the rates of latent EB viral infection in the sporadic and immunodeficiencyassociated form ...
C UL1, H
... We have investigated the previously uncharacterized human cytomegalovirus (HCMV) UL1 open reading frame (ORF), a member of the lately evolving HCMV RL11 gene family. UL1 is HCMV specific; absence of UL1 in chimpanzee CMV (CCMV) and sequence analysis studies suggests that UL1 may have originated by d ...
... We have investigated the previously uncharacterized human cytomegalovirus (HCMV) UL1 open reading frame (ORF), a member of the lately evolving HCMV RL11 gene family. UL1 is HCMV specific; absence of UL1 in chimpanzee CMV (CCMV) and sequence analysis studies suggests that UL1 may have originated by d ...
Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms REVIEW
... bronchiectasis had higher levels of apoptotic neutrophils than patients with chronic bronchitis. Apoptotic cells target themselves for recognition and uptake into phagocyte-expressing surface ligands, in particular phosphatidylserine (PS), which interacts with specific receptors on the macrophages s ...
... bronchiectasis had higher levels of apoptotic neutrophils than patients with chronic bronchitis. Apoptotic cells target themselves for recognition and uptake into phagocyte-expressing surface ligands, in particular phosphatidylserine (PS), which interacts with specific receptors on the macrophages s ...
Resistance and Adaptation to Food Antimicrobials
... Responses of Microorganisms to Antimicrobials and Sanitizers If a population of microorganisms is exposed to a sufficiently high concentration of an antimicrobial compound, susceptible cells will be killed. However, some cells may possess a degree of natural resistance or they may acquire it later t ...
... Responses of Microorganisms to Antimicrobials and Sanitizers If a population of microorganisms is exposed to a sufficiently high concentration of an antimicrobial compound, susceptible cells will be killed. However, some cells may possess a degree of natural resistance or they may acquire it later t ...
Mapping the inhibitory determinants within the cytoplasmic tail of CD6
... response. It is mediated by the performance of a particular type of receptors, the pattern recognition receptors (PRRs). These recognize broad groups of pathogens in a non-specific manner and target the pathogen-associated molecular patterns (PAMPs). Not only are PRRs able to stimulate tissue-reside ...
... response. It is mediated by the performance of a particular type of receptors, the pattern recognition receptors (PRRs). These recognize broad groups of pathogens in a non-specific manner and target the pathogen-associated molecular patterns (PAMPs). Not only are PRRs able to stimulate tissue-reside ...
Toxoplasma gondii effectors are master regulators of the
... single strain can generate both micro- and macrogametes, selfmating is very probable because the vast majority of intermediate hosts harbor cysts from just a single strain. However, in the rare occasion a feline gets infected with two distinct Toxoplasma strains sexual recombination can occur, and u ...
... single strain can generate both micro- and macrogametes, selfmating is very probable because the vast majority of intermediate hosts harbor cysts from just a single strain. However, in the rare occasion a feline gets infected with two distinct Toxoplasma strains sexual recombination can occur, and u ...
Nature Medicine 10, 1307
... The iconography of journals, meeting posters and books for the last few decades of the twentieth century makes apparent the preeminence of antigen-related recognition in immunological thinking. Beginning in the 1970s, the polypeptide chain organization of antibodies4, 5, 6 was a ubiquitous image. I ...
... The iconography of journals, meeting posters and books for the last few decades of the twentieth century makes apparent the preeminence of antigen-related recognition in immunological thinking. Beginning in the 1970s, the polypeptide chain organization of antibodies4, 5, 6 was a ubiquitous image. I ...
Principal Investigator/Program Director (Last, First, Middle): Halonen
... Major Goal: To investigate the mechanism of IFNγ inhibition of Toxoplasma gondii in astrocytes. IFNγ Immune Effector Mechanisms in Cerebral Toxoplasmosis P.I.: Sandra K. Halonen Agency: National Institute of Allergy & Infectious Disease Type: R21 AI64652-01 Funding Period: 3/14/05- 3/14/08 Major Goa ...
... Major Goal: To investigate the mechanism of IFNγ inhibition of Toxoplasma gondii in astrocytes. IFNγ Immune Effector Mechanisms in Cerebral Toxoplasmosis P.I.: Sandra K. Halonen Agency: National Institute of Allergy & Infectious Disease Type: R21 AI64652-01 Funding Period: 3/14/05- 3/14/08 Major Goa ...
Anabolic androgenic steroids effects on the immune system: a review
... of the AAS to form for example esters contributes to variations in binding specificity to receptors or steroid metabolizing enzymes [22-24]. The mechanism of action of all AAS is similar to all other steroid hormones in that it binds to an intracellular protein, known as an androgen receptor, in t ...
... of the AAS to form for example esters contributes to variations in binding specificity to receptors or steroid metabolizing enzymes [22-24]. The mechanism of action of all AAS is similar to all other steroid hormones in that it binds to an intracellular protein, known as an androgen receptor, in t ...
PDF （582KB）
... inflammation of the ocular surface microenvironment. Most cases of dry eye disease are secondary to any of a vast array of inflammatory conditions and disorders, including auto- and alloimmune diseases, infection, aging, neuroinflammation, and sterile Inflammation. Sterile inflammation is induced by ...
... inflammation of the ocular surface microenvironment. Most cases of dry eye disease are secondary to any of a vast array of inflammatory conditions and disorders, including auto- and alloimmune diseases, infection, aging, neuroinflammation, and sterile Inflammation. Sterile inflammation is induced by ...
T cells - Amazon S3
... within plasma Antibodies resist disease first by recognizing foreign or abnormal substances (Figure 21-19) ...
... within plasma Antibodies resist disease first by recognizing foreign or abnormal substances (Figure 21-19) ...
Introduction to the Skin
... Necrolytic migratory erythema – often occurs in groin area. It is a red, blistering rash that spreads across the skin. It is strongly associated with glucagonoma, but also liver disease + intestinal malabsorption. Common warts – common skin disease caused by HPV which causes rapid growth of cells on ...
... Necrolytic migratory erythema – often occurs in groin area. It is a red, blistering rash that spreads across the skin. It is strongly associated with glucagonoma, but also liver disease + intestinal malabsorption. Common warts – common skin disease caused by HPV which causes rapid growth of cells on ...
Lipid rafts facilitate LPS responses - Journal of Cell Science
... Existence of receptor molecules involved in LPS-cellular activation in lipid rafts after LPS stimulation In order to investigate whether the distribution of molecules involved in LPS-cellular activation changes after LPS stimulation, we stimulated MonoMac-6 or CHO/CD14/TLR4 cells with LPS and lysed ...
... Existence of receptor molecules involved in LPS-cellular activation in lipid rafts after LPS stimulation In order to investigate whether the distribution of molecules involved in LPS-cellular activation changes after LPS stimulation, we stimulated MonoMac-6 or CHO/CD14/TLR4 cells with LPS and lysed ...
Epidermal Growth Factor Receptor Protein
... the AEV appears to represent a truncated EGF receptor con taining the cytoplasmic kinase domain but lacking any sequence corresponding to the extracellular ligand-binding domain (2, 16). Furthermore, the \-erbB protein has undergone a C-terminal modification in which 32 amino acids of the EGF recep ...
... the AEV appears to represent a truncated EGF receptor con taining the cytoplasmic kinase domain but lacking any sequence corresponding to the extracellular ligand-binding domain (2, 16). Furthermore, the \-erbB protein has undergone a C-terminal modification in which 32 amino acids of the EGF recep ...
Suppression of adaptive immune responses during primary SIV
... macaques from pathogenic SHIV89.6P challenge after passive transfer of broadly NAbs.13,14 Recently, a limited number of studies have evaluated the role of B cell–mediated immune responses in SIV containment in rhesus macaques.15-17 Humoral immune responses did not contribute to viral containment in ...
... macaques from pathogenic SHIV89.6P challenge after passive transfer of broadly NAbs.13,14 Recently, a limited number of studies have evaluated the role of B cell–mediated immune responses in SIV containment in rhesus macaques.15-17 Humoral immune responses did not contribute to viral containment in ...