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Shigella stability - Health in Emergencies and Disasters Quarterly
Shigella stability - Health in Emergencies and Disasters Quarterly

... coli, Salmonella, Klebsiella, Proteus, Entrobacter and Shigella are the main members of this family. Despite normal flora of human intestine is composed of some of this group like E. coli, but the presence of some other members such as various strains of Shigella can cause disease in human [2 ,3]. F ...
Basophils, IgE, and Autoantibody-Mediated Kidney
Basophils, IgE, and Autoantibody-Mediated Kidney

INDUCTION OF INNATE IMMUNE RESPONSES BY PLANT
INDUCTION OF INNATE IMMUNE RESPONSES BY PLANT

... Dr. Mark Jutila ...
Sustained viral load and late death in Rag2-/
Sustained viral load and late death in Rag2-/

... Rag2-/- mice are defective in the recombination machinery which is required for development of both B and T cells but are able to produce NK cells [15-17]. No other innate immune cells are affected by these mutations. Rag1-/- mice died between day 10 and 12 after primary infection with influenza A v ...
Full-Text PDF
Full-Text PDF

Hutchinson JF ARA2001
Hutchinson JF ARA2001

... mutations that facilitate adaptation (Doms & Moore 1997). That is, some mutants may be able to infect previously uninfected tissues. The genetic diversity of the HIV virus results in drug resistance and evasion from immune responses and makes development of a vaccine a challenge (Bonhoeffer et al 19 ...
- AMS Dottorato
- AMS Dottorato

... Although the gastrointestinal tract is a long tubular structure, different parts of the gastrointestinal tract vary markedly in morphology, the wall of the entire tube (from the oesophagus to the rectum) shares common structural features. When viewed under a microscope, the wall of the gastrointest ...
Optimization of peripheral blood mononuclear cell
Optimization of peripheral blood mononuclear cell

... delays, over the course of recovery from a respiratory infection. Another study, SMAF-001, was conducted with SMA patients and carriers were conducted at a Phase 1 clinical study unit. In healthy volunteers there were up to 10 fold differences in SMN protein levels between individuals, and in the sa ...
THE HLA SYSTEM
THE HLA SYSTEM

... This technique can be refined by treating the lymphocytes from one of the individuals to prevent cell division, for example by irradiation. It is thus possible to measure the response of T lymphocytes from one individual to a range of foreign lymphocytes. It has thus proved possible by using the mix ...
Local Immune Responses in Human Tuberculosis: Learning From
Local Immune Responses in Human Tuberculosis: Learning From

... tuberculosis–infected macrophages can transform into epitheliod cells and also fuse to form multinucleated giant cells (MGCs). Classically activated macrophages (CAMs) are more bactericidal and control M. tuberculosis replication better than do alternatively activated macrophages (AAMs). Secretion o ...
Bone transplantation and immune response
Bone transplantation and immune response

... Only class I and II are involved in allotransplatation. MHC molecules are heterodimeric transmembrane glycoproteins that belong to the immunoglobulin superfamily. They are able to present endogenous and foreign peptides on the surface of antigen-presenting cells (APC) and communicate with T cells. A ...
Antibacterial Drugs
Antibacterial Drugs

Section 2 Specific Defense
Section 2 Specific Defense

... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
MB_47_win
MB_47_win

... • B cells are white blood cells that are made in the bone marrow and complete their development there or in the spleen. B cells make antibodies. • T cells are cells that are made in the bone marrow but complete their development only after traveling to the thymus. T cells also participate in many im ...
Altered frequency and migration capacity of CD4
Altered frequency and migration capacity of CD4

Virus interactions with dendritic cells
Virus interactions with dendritic cells

Herpes simplex virus and varicella zoster virus, Open Access
Herpes simplex virus and varicella zoster virus, Open Access

... There are numerous small animal models that accurately reflect primary infection, latency, and reactivation of HSV-1 in humans, but no animal model reproduces varicella, latency and zoster. Moreover, VZV is exceedingly difficult to experimentally reactivate from human ganglia. The lack of animal mod ...
Tissue adaptation: Implications for gut immunity and tolerance
Tissue adaptation: Implications for gut immunity and tolerance

... epithelium-specific challenges (Huang et al., 2011). Regardless of the subset in which it is expressed, CD8αα decreases antigen sensitivity of the TCR negatively regulating T cell activation (Cheroutre and Lambolez, 2008). Therefore, both CD4+ and CD8+ pIELs acquire features that distinguish these c ...
Acute effects of tobacco smoke on human
Acute effects of tobacco smoke on human

... [13–15]. The highest numbers of mDCs with a Langerhans’ cell phenotype are found in the airways of smokers with COPD [6] or PLCH [16]. The present study is the first to demonstrate that acute tobacco smoke exposure leads to immediate recruitment of mDCs into human airways in vivo. This recruitment w ...
Toll-like receptor 9 activation: a novel mechanism
Toll-like receptor 9 activation: a novel mechanism

Non-infectious manifestations of Common Variable
Non-infectious manifestations of Common Variable

Immunity and Gastrointestinal Disease: A Role for Lymphatic Vessels
Immunity and Gastrointestinal Disease: A Role for Lymphatic Vessels

Host Antimicrobial Peptides in Bacterial Homeostasis and
Host Antimicrobial Peptides in Bacterial Homeostasis and

¿Manipulan los ácaros el sistema inmunológico?
¿Manipulan los ácaros el sistema inmunológico?

... essential for LPS recognition and the initiation of TLR4 signalling. • Der p 2 could reconstitute LPS induced TLR4 signalling in cells that lack MD2 and also could enhance the response in the presence of MD2 • LPS–Der p 2 complex might mimic the TLR4 activating properties of the LPS–MD2complex. ...
Relevance of granulocyte apoptosis to resolution of
Relevance of granulocyte apoptosis to resolution of

... ensnare and kill resistant organisms but must themselves die in the process.7 In beneficial neutrophil-dominant inflammation, the organisms or foreign particles are detected and phagocytosed by neutrophils, which then undergo an organized, nonprovocative programmed cell death (apoptosis) that promot ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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