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Progresses on Studies of Highly Pathogenic Avian Influenza H5N1
Progresses on Studies of Highly Pathogenic Avian Influenza H5N1

... basic amino acid (-RRRKR- or -RRRKKR (Arg, R; Lys, K)) in the HA cleavage site. Of note, the motif of high pathogenicity may be invalid on nonhuman primate animal [53]. The polymerase genes (PB2, PB1 and PA) are the important determinants of viral pathogenicity and host restriction as well. The inte ...
The effect of induced hyperthermia on the
The effect of induced hyperthermia on the

Escherichia coli Urinary Tract Infections
Escherichia coli Urinary Tract Infections

...  Typing strains is based on differences in three structural antigens: O, H, and K (Figure 1). The O antigens (somatic or cell wall antigens) are found on the polysaccharide portion of the LPS. These antigens are heat stable and may be shared among different Enterobacteriaceae genera. O antigens are ...
Amoxicillin sodium salt PRODUCT DATA SHEET - TOKU-E
Amoxicillin sodium salt PRODUCT DATA SHEET - TOKU-E

... sparingly soluble (3.4 mg/mL). Both forms have similar potencies and are suitable for microbiology use; however, amoxicillin sodium is easier to work with in aqueous solution. Clavulanate potassium (clavulanic acid) is a β­ lactamase inhibitor which can irreversibly inactivate β­lactamase enzymes of ...
thesis - KI Open Archive
thesis - KI Open Archive

... There is a constant communication between cells and tissues in terms of cytokines, chemokines and cell-to cell contact. One important task of the innate immune system is to differ self from non-self. One instrument to do so is through pattern recognition molecules, which includes Toll-like receptors ...
Monomers Peptidoglycan, but Not to Peptidoglycan Respond
Monomers Peptidoglycan, but Not to Peptidoglycan Respond

Microbiota-mediated colonization resistance against intestinal
Microbiota-mediated colonization resistance against intestinal

... are resistant to environmental stresses and sterilization measures; this facilitates its transmission between patients in hospital settings. C. difficile is resistant to many classes of antimicrobials13–15 that create broad and lasting deficits in the composition and diversity of the intestinal micr ...
Detection of Post-Transplant Anti-HLA Donor
Detection of Post-Transplant Anti-HLA Donor

... Transplant recipients who have sensitizing events such as pregnancies, blood transfusions and previous transplants often develop antibodies directed against human leukocyte antigen (HLA)-molecules of the donors’ organs. These pre-formed donor-specific antibodies (DSA) represent a high risk of organ ...
Folia Microbiologica
Folia Microbiologica

... of H. pylori binding to gastric epithelial cells could represent a potential target for therapy, the aim of this study was to evaluate whether exocellular polysaccharides from cyanobacterial strains Cyanothece spp. and Cyanospira capsulata, having different monosaccharide composition and anionic cha ...
Peptidoglycan-associated lipoprotein (Pal) of Gram
Peptidoglycan-associated lipoprotein (Pal) of Gram

... interacts strongly with TolB, resulting in destabilization of the Tol–Pal complex. TolB binding with Pal occurs through an induced-fit mechanism in which both proteins undergo conformational changes (Bonsor et al., 2007). In addition, the interactions of TolB with other proteins (OmpA and Lpp) are d ...
poster - Natural Killer Cell Symposium
poster - Natural Killer Cell Symposium

... against NK cell mediated cytolysis of normal healthy cells. Activating ligands, however, are usually stress-induced antigens signaling cellular distress caused by transformation or infection. Expression of such antigens will evoke NK cellular responses inducing lysis of the expressing cell and cytok ...
Here - European Macrophage and Dendritic Cell Society
Here - European Macrophage and Dendritic Cell Society

Delivery strategies to enhance oral vaccination against
Delivery strategies to enhance oral vaccination against

... ETEC is also a leading cause of Traveller’s Diarrhoea in visitors to endemic regions. Recently, oral vaccine efforts against ETEC have focused on the generation of whole cell killed (WCK) bacteria expressing colonisation factor antigens (CFAs), a family of molecules that mediate the attachment of ET ...
Correlations among measles virus
Correlations among measles virus

... Immunity to measles is conferred by the interplay of humoral and cellular immune responses, the latter being critical in maintaining long-term recall response. Therefore, it is important to evaluate measles-specific humoral and cellular immunity in populations several years after vaccination and und ...
CD8 -Mediated Survival and Differentiation of CD8 Memory T Cell
CD8 -Mediated Survival and Differentiation of CD8 Memory T Cell

... CD8␣␤ T cells. Consistent with this idea, CD8␣␣⫹ splenic OT-1 transgenic T cells that had been activated by APC/TL retained high levels of the antiapoptotic factors BclxL (Fig. 1C) and Bcl-2 (fig. S2) (16). The high levels of survival factors were dependent on TL expression by the APC and could be b ...
Mechanisms of Multi-strain Coexistence in Host
Mechanisms of Multi-strain Coexistence in Host

The use of antibodies in the treatment of infectious diseases
The use of antibodies in the treatment of infectious diseases

... There is a long history of the use of antibodies in the treatment and prophylaxis of infectious diseases, because these molecules play a critical role in directing the effector mechanisms of the immune system against the pathogens they recognise. However, the widespread application of this therapy h ...
Recent Advances in Researches on Shrimp Immune Pathway
Recent Advances in Researches on Shrimp Immune Pathway

... infection, the host innate immune system activated microbial clearing pathways and cellular stress relief pathways that needed to be balanced for insufficient or excessive immune responses leading to deleterious consequences. Shrimp is an invertebrate with open circulatory system, especially prone t ...
Assigned Reading - Esko Lab - University of California San Diego
Assigned Reading - Esko Lab - University of California San Diego

Surfactant proteins and the inflammatory and immune response in
Surfactant proteins and the inflammatory and immune response in

... ison with patients with a cough. Increased levels of SPD are found in the BALF of patients with eosinophilic pneumonia compared with healthy controls.20 Surfactant protein A prevents inhibition of surfactant activity by blood proteins. Leakage of blood components into the alveolar space as a result ...
A Diagnostic Target Against Clostridium bolteae
A Diagnostic Target Against Clostridium bolteae

... pyranose. A) α-D-glucose ring closure and B) β-D-glucose ring closure.................. 2 Figure 2: A figure depicting the two chair conformations observed for the pyranose forms of sugars. The 4C1 configuration is named such due to the C4 being positioned upwards in space, with the C1 positioned do ...
raise the production of growth hormone naturally
raise the production of growth hormone naturally

... helps wi5th cell differentiation, also causing the formation of cells that lay down bone and cartilage, which function continues well past the time when bones stop lengthening and linear body growth stops HGH causes a decrease in the utilisation of protein for energy production and increases the mob ...
How to naturally raise your Human Growth Hormone levels
How to naturally raise your Human Growth Hormone levels

... helps wi5th cell differentiation, also causing the formation of cells that lay down bone and cartilage, which function continues well past the time when bones stop lengthening and linear body growth stops HGH causes a decrease in the utilisation of protein for energy production and increases the mob ...
Activation of Innate Immune Responses by Non
Activation of Innate Immune Responses by Non

Chapter 28. Vitamin D: Production, Metabolism, Mechanism of
Chapter 28. Vitamin D: Production, Metabolism, Mechanism of

... VDR functions as a heterodimer with the retinoid X receptor (RXR) for activation for vitamin D target genes. Once formed, the l,2S(OH),D3-VDR-RXR heterodimeric complex interacts with specific D N A sequences (vitamin D response elements [VDRE]) within the promoter of target genes, resulting in eithe ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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