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Gene Delivery Course - University of Pittsburgh
Gene Delivery Course - University of Pittsburgh

Immunosuppresion for SLE
Immunosuppresion for SLE

... Currently a lot of research going on into the possibility of achieving tolerance with sirolimus (spares Tregs in contrast to CsA) and/or abatacept ...
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... are transiently produced by almost any nucleated cell A group of regulatory molecules, which function as important mediators of cell communication under normal as well as pathological conditions and also have therapeutic potential ...
Immune System
Immune System

... My first is in bright but not in light. My second in light but not in right. My third in up but not in at. My last in eat but not in hat. My whole a color you will find. Keep that idea clear in mind. ...
Immune System Skit
Immune System Skit

... Put in HW Assignment Name: T4D10 Immune System Musical Date: ...
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T cells

The application of gene therapy in autoimmune diseases
The application of gene therapy in autoimmune diseases

Immune Response to Infectious Diseases Objective Questions 1
Immune Response to Infectious Diseases Objective Questions 1

... 1. What are the major groups of pathogens? Provide examples of diseases caused by each of the groups. 2. In general, why are infectious diseases such a huge problem world wide? 3. What is the basic structure of a virus? 4. Explain the viral replication process, in generic terms. 5. Describe the host ...
Lymphatic System Vocabulary
Lymphatic System Vocabulary

... parts: 1) lymphatic vessels that transport fluids that have escaped from the circulatory system back to the blood & 2) lymphoid tissues & organs: house phagocytic cells & lymphocytes, which play essential roles in body defense & resistance to disease. It is a low pressure but pumpless system where l ...
The Lymphatic System
The Lymphatic System

... Millions different lymphocytes w/diff antigen receptors ...
Neonatal Immunology
Neonatal Immunology

... transferred to the infant via breast milk. The main immunoglobulin class transferred is IgA, the transferred IgA works at mucosal surfaces, where it is able to prevent pathogen entry. However other important factors are transferred, including complement and commensal bacteria – which may provide pro ...
Document
Document

... transferred to the infant via breast milk. The main immunoglobulin class transferred is IgA, the transferred IgA works at mucosal surfaces, where it is able to prevent pathogen entry. However other important factors are transferred, including complement and commensal bacteria – which may provide pro ...
MICROBIAL GROWTH
MICROBIAL GROWTH

... • Usually means an increase in size however….. • Microbes grow by increasing in number and not in size • They can accumulate into clumps of hundreds and colonies of thousands • COLONIES = large number of microbes usually derived from one organism (clone) • Unicellular organisms do grow in size but O ...
CTLA-4
CTLA-4

... the non-redundant function of IL-2 is in controlling immune responses (generalized autoimmune disease) ...
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Bacteria/Virses

... sores (fever blisters) are caused by an infection with the herpes simplex virus. ...
Chapter 21
Chapter 21

... 4. CD8 (T8) cells - cytotoxic and suppressor T cells B. Primary Functions of T Cells 1. B cells can recognize and make antibodies to free antigens in serum or on the surface of microbes; prepares antigen for destruction 2. T cells can only recognize antigens that have been processed and are present ...
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... know what types of antigens and antibodies are found type A, B, AB, and O blood, who each can receive blood from and give blood to, RH+ and Rhknow the complement protein system’s different functions know why organ transplants are often rejected, and how this can be reduced know role of antibodies (B ...
IMT- II PG - E
IMT- II PG - E

... c. adjuvants d. carriers 23. The ability of an individual antibody – combing site to react with more than one antigenic determinant site of the antigen is called ___________ a. Cross reactivity b. affinity of antibody c. avidity of antibody d. specificity of antibody ...
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Chapter 4

... Bacterial morphologies • Morphology can be used as an initial identifier • However, shape can change in some bacteria depending on environs – “pleomorphic” cells ...
Chapter 13
Chapter 13

... Although lymphocyte extravasation is similar to neutrophils, different subsets of lymphocytes must make it into different tissues ○ Naïve lymphocytes  Migrate to secondary lymphoid tissue to encounter antigen ○ Effector and memory lymphocytes  Home to regions of infection  Memory cells will tend ...
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2006 – San Diego, CA

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12.2 Review Questions What happens when serum containing B

... 1. What happens when serum containing B antibodies is added to red blood cells carrying the B antigen? Will the same thing happen if serum containing B antibodies is added to red blood cells containing A antigen? Explain your answer. 2. What is serology and what is its most widespread application? I ...
f212 health and disease
f212 health and disease

... Stages in phagocytosis • Pathogens are recognised by antigens on their surface • Phagocyte moves towards pathogen and receptors on the cell surface membrane attach to antigens on the pathogen • Phagocyte engulfs the pathogen creating a ...
a case of hashimoto`s thyroiditis with autoimmune haemolytic anaemia
a case of hashimoto`s thyroiditis with autoimmune haemolytic anaemia

... DISCUSSION: Autoimmune diseases comprise of a heterogeneous group of disorders and are sometimes defined as a clinical syndrome caused by alterations in the immune system such as activation of T cells or B cells or both, resulting in a spectrum of diseases that can target specific organs or affect t ...
Use of magnetic beads for isolation of antigen
Use of magnetic beads for isolation of antigen

... splenocytes fused with myeloma cells have been used. These antibodies are now being used for therapy (1-4) but for many reasons, human or humanised monoclonals are more effective in activating human effector functions, to eliminate antigens and also avoid reactions against murine antibodies. ...
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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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