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... cells (pDCs), single stranded viral RNA is exposed by viral capsid degradation in the acidified endosomes for detection by TLR7. The production of pro-inflammatory cytokines and type I interferons are induced through the RIG I and TLR7 pathways. IRF7 (interferon regulatory factor 7) and NF-kB are ac ...
... cells (pDCs), single stranded viral RNA is exposed by viral capsid degradation in the acidified endosomes for detection by TLR7. The production of pro-inflammatory cytokines and type I interferons are induced through the RIG I and TLR7 pathways. IRF7 (interferon regulatory factor 7) and NF-kB are ac ...
... of FAMs were HLA-DR+, the percentage of NANR and LAM cells expressing this marker was 51±12% and 65±6%, respectively (table 1). Thus, the ability of enriched cell fractions isolated from exudative malignant pleural effusions to function as accessory cells in mixed leucocyte reaction experiments was ...
The role of intestinal microbiota and the immune system
... from the Th2 cytokine profile to a Th1-type profile, resulting in the development of enhanced Th2-cell responses to allergens34-36. However, this explanation does not take into account that the prevalence of Th1-associated diseases, such as Crohn’s disease, type 1 diabetes and multiple sclerosis, wa ...
... from the Th2 cytokine profile to a Th1-type profile, resulting in the development of enhanced Th2-cell responses to allergens34-36. However, this explanation does not take into account that the prevalence of Th1-associated diseases, such as Crohn’s disease, type 1 diabetes and multiple sclerosis, wa ...
Thioaptamer decoy targeting of AP-1 proteins influences cytokine
... Viral haemorrhagic fever (VHF) is caused by a number of viruses, including arenaviruses. The pathogenesis is believed to involve dysregulation of cytokine production. The arenaviruses Lassa virus and Pichinde virus have a tropism for macrophages and other reticuloendothelial cells and both appear to ...
... Viral haemorrhagic fever (VHF) is caused by a number of viruses, including arenaviruses. The pathogenesis is believed to involve dysregulation of cytokine production. The arenaviruses Lassa virus and Pichinde virus have a tropism for macrophages and other reticuloendothelial cells and both appear to ...
The plasmacytoid dendritic cell: at the cross-roads in asthma
... recognise ssRNA (as well as other microbial motifs), can induce IFN-I production by pDCs [32, 34, 35]. RIG-I has been shown to be functional in pDCs but only in the absence of TLR responsiveness [35]; however, RIG-I deficiency does not affect IFN-I or IL-6 production in response to infection with ss ...
... recognise ssRNA (as well as other microbial motifs), can induce IFN-I production by pDCs [32, 34, 35]. RIG-I has been shown to be functional in pDCs but only in the absence of TLR responsiveness [35]; however, RIG-I deficiency does not affect IFN-I or IL-6 production in response to infection with ss ...
Proteomic characterization of host response to viral infection
... 1. INTRODUCTION Host cell defense responses against viruses are initiated immediately after viruses’ invasion to the cell. Innate immune system is a complex network of interconnected biological pathways that are responsible of organism’s first defence responses against viruses. Therefore, the study ...
... 1. INTRODUCTION Host cell defense responses against viruses are initiated immediately after viruses’ invasion to the cell. Innate immune system is a complex network of interconnected biological pathways that are responsible of organism’s first defence responses against viruses. Therefore, the study ...
Immunology Module
... Option #1: If time permits, instruct your students to let their bottles sit overnight! When they return to the classroom the following morning, have them observe and record any changes that occurred from when they left their bottles the day before. These observations will be recorded on Worksheet #1 ...
... Option #1: If time permits, instruct your students to let their bottles sit overnight! When they return to the classroom the following morning, have them observe and record any changes that occurred from when they left their bottles the day before. These observations will be recorded on Worksheet #1 ...
Expression of NTRK1/TrkA affects immunogenicity of neuroblastoma
... upregulation of major histocompatibility complex (MHC) class I complexes on TrkA-expressing cells. Corresponding to this upregulation, T cell activity and cytoxicity was enhanced in the presence of SY5Y-TrkA cells or by medium conditioned by them, suggesting the existence of additional soluble facto ...
... upregulation of major histocompatibility complex (MHC) class I complexes on TrkA-expressing cells. Corresponding to this upregulation, T cell activity and cytoxicity was enhanced in the presence of SY5Y-TrkA cells or by medium conditioned by them, suggesting the existence of additional soluble facto ...
Immune system fighting malignancy
... antigen-presenting cells to induce an antitumor response in vivo through the activation of T cells. Thus far, mostly epitope-specific peptides with 8–10 amino acids in length have been used to generate DC vaccines, which however activate only CD8+ T cells. Moreover, available single epitope-specifi ...
... antigen-presenting cells to induce an antitumor response in vivo through the activation of T cells. Thus far, mostly epitope-specific peptides with 8–10 amino acids in length have been used to generate DC vaccines, which however activate only CD8+ T cells. Moreover, available single epitope-specifi ...
The Cell Biology of Multi-nucleated Giant Cell Formation
... pathway shares common features with the TLR4 pathway induced by LPS, but in ...
... pathway shares common features with the TLR4 pathway induced by LPS, but in ...
Neuroendocrine cells of nasal mucosa are a cellular source of
... neurokinin A/B. These neuropeptides are involved in several key features of asthma, including airway smooth muscle constriction, vascular dilatation, increased vascular permeability and mucus hypersecretion [11]. In the immune system, NTs induce differentiation of B-lymphocytes, induce cytokine synt ...
... neurokinin A/B. These neuropeptides are involved in several key features of asthma, including airway smooth muscle constriction, vascular dilatation, increased vascular permeability and mucus hypersecretion [11]. In the immune system, NTs induce differentiation of B-lymphocytes, induce cytokine synt ...
Jenny Walldén Studies of immunological risk factors in type 1 diabetes
... This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulatory T cells between healthy children, children at risk of T ...
... This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulatory T cells between healthy children, children at risk of T ...
Use of Stem Cells for Autism Treatment
... 2. Stem Cells in Autism Spectrum Disorders It is generally agreed that stem cell therapies represent the future of molecular and regenerative medicine for what would otherwise be untreatable human diseases. Stem cells are also suitable for developing cell-based patient-specific pharmacotherapies [10 ...
... 2. Stem Cells in Autism Spectrum Disorders It is generally agreed that stem cell therapies represent the future of molecular and regenerative medicine for what would otherwise be untreatable human diseases. Stem cells are also suitable for developing cell-based patient-specific pharmacotherapies [10 ...
Licentiate thesis from the Department of Immunology,
... and therefore the initial quality of the innate immune response may direct the proceeding activation of the adaptive immune responses.8 Traditionally, adaptive immunity is divided into two different branches; 1) the cell-mediated response, in which the effector cells are antigen-specific T cells, an ...
... and therefore the initial quality of the innate immune response may direct the proceeding activation of the adaptive immune responses.8 Traditionally, adaptive immunity is divided into two different branches; 1) the cell-mediated response, in which the effector cells are antigen-specific T cells, an ...
Celiac Disease, Inflammation and Oxidative Damage: A
... 2.2.2. Effect of Gluten on Gene Expression: Relationship with Oxidative Stress and Inflammation Several studies have demonstrated that gliadin peptides are able to modulate gene expression in several cellular models [57,58]. The increased levels of ROS is involved in the reduced degradation of tTG b ...
... 2.2.2. Effect of Gluten on Gene Expression: Relationship with Oxidative Stress and Inflammation Several studies have demonstrated that gliadin peptides are able to modulate gene expression in several cellular models [57,58]. The increased levels of ROS is involved in the reduced degradation of tTG b ...
induction of nasopharyngeal mucosal immune responses in the horse
... stimulation of protective mucosal immune responses does not result from parenterally inoculated vaccines but rather requires local induction. Moreover, mucosal immunization often induces a combination of systemic and local responses associated with production of a greater variety of immunoglobulin s ...
... stimulation of protective mucosal immune responses does not result from parenterally inoculated vaccines but rather requires local induction. Moreover, mucosal immunization often induces a combination of systemic and local responses associated with production of a greater variety of immunoglobulin s ...
E SE HAHNEMANN NON AVESSE LETTO KANT
... and its procoagulant activity [15]. Elegant animal models suggest that the immunitary reaction to CMV has a role in the aetiopathogenesis of vascular damage, especially as concerns the high endothelial sensitivity to infection [16], also when viral Dna is not present in the atherosomatic site. Simil ...
... and its procoagulant activity [15]. Elegant animal models suggest that the immunitary reaction to CMV has a role in the aetiopathogenesis of vascular damage, especially as concerns the high endothelial sensitivity to infection [16], also when viral Dna is not present in the atherosomatic site. Simil ...
Mesenchymal Stem Cell Population Derived from
... in both preclinical animal models and clinical trials currently underway. However, differences in quality of donor cells, tissue sources, and culture methods have caused numerous inconsistencies in the reported in vivo effectiveness of MSCs [24–27]. Their limited quantity necessitates in vitro cultu ...
... in both preclinical animal models and clinical trials currently underway. However, differences in quality of donor cells, tissue sources, and culture methods have caused numerous inconsistencies in the reported in vivo effectiveness of MSCs [24–27]. Their limited quantity necessitates in vitro cultu ...
