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14RLattesCaseTID
14RLattesCaseTID

...  Results of sterotactic biopsy: amastigotes nests and ...
Chapter 9 Lymphatic System The lymphatic system is examined
Chapter 9 Lymphatic System The lymphatic system is examined

... Herpes simplex (HSV) Infection by human herpes virus 1 (HSV-1) or human herpes virus 2 (HSV-2) Abnormalities (Cont.) ...
The pressure mounts on lung dendritic cells EDITORIAL
The pressure mounts on lung dendritic cells EDITORIAL

... induced PAH. This is striking, as the pulmonary arteries are not frequently exposed to foreign pathogens. The most likely explanation for the increased numbers of DCs in this region would be the recruitment of DCs in response to tissue damage and the release of the associated DAMPs. It is indeed kno ...
Antitumor immunity by magnetic nanoparticle
Antitumor immunity by magnetic nanoparticle

... immune response. The diversity of DAMPs is related to the type of cell death, cells and tissue injuries they are involved with [43] . Hyperthermia may induce multiple distinct types of tumor cell death, such as apoptosis, necrosis and autophagy, which may occur concurrently or successively. The immu ...
Cleavage of Anti-Apoptotic Bcl-2 Family Members after TCR
Cleavage of Anti-Apoptotic Bcl-2 Family Members after TCR

Activation of myeloid dendritic cells, effector cells and regulatory T
Activation of myeloid dendritic cells, effector cells and regulatory T

... tolerance and the prevention of autoimmune and inflammatory diseases [6, 7]. Tregs express the transcription factor Foxp3 and are classified according to their origin as either thymus-derived Tregs (tTreg), which recognize self antigens, or peripherally derived Tregs (pTreg), which recognize antigen ...
Adrenocorticotropic hormone: a molecule for all seasons
Adrenocorticotropic hormone: a molecule for all seasons

... addition to the formation of amyloid fibrils, the parasitization triggers host immunocytes to release ACTH-like and melanocyte-stimulating hormone-like (α-MSH-like) molecules and neutral endopeptidase (NEP). As stated above, ACTH-like mediators are involved in the migration and activation of circula ...
Protein degradation systems in viral myocarditis leading to dilated
Protein degradation systems in viral myocarditis leading to dilated

Protein Supplementation during Exercise
Protein Supplementation during Exercise

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Dendritic Cell Biology - Wiley-VCH
Dendritic Cell Biology - Wiley-VCH

... what are the natural ligands for many of these such as DEC-205/CD205, langerin/CD207, and a host of other lectins? Interestingly, antibodies to these receptors can be engineered to express defined antigens, and this would seem to be an important new way to analyze receptor and dendritic cell functio ...
A basis for comparison: sensitive authentication of stem cell derived
A basis for comparison: sensitive authentication of stem cell derived

Inflammation in the Bovine Female Reproductive Tract
Inflammation in the Bovine Female Reproductive Tract

... lesser extent the reproductive tract, an effective system of mucosal defense, including mucosal inflammation, has developed at this interface. Immune protection of the reproductive tract requires most of the same cellular and chemical strategies as do other mucosal surfaces. However, some unique inf ...
Effects of intracellular and extracellular heat shock proteins on anti
Effects of intracellular and extracellular heat shock proteins on anti

... instructed and regulated by antigen-presenting cells (APCs). Dendritic cells (DC) are unique APCs because they are the only ones that are able to induce primary immune responses, thus permitting the establishment of immunological memory (Banchereau et al. 1998). DC progenitors in the bone marrow giv ...
100500 T-Cell Function and Migration
100500 T-Cell Function and Migration

... chemokines (a process called haptotaxis), which may persist at high concentrations in tissues longer than do freely diffusible chemoattractants. Since lymphocytes must be positioned correctly to interact with other cells, the pattern of chemokine receptors and the type and distribution of chemokines ...
TOLL-like receptors linking innate and adaptive immune response
TOLL-like receptors linking innate and adaptive immune response

... constituent of host cells. TLR3-de®cient mice showed decreased responses to the viral RNA mimic, polyinosinic±polycytidylic acid (poly(I:C)), suggesting that TLR3 is involved in the recognition of dsRNA (Alexopoulou et al., 2001). Viral dsRNA binding to cell surface-expressed TLR3 may be derived fro ...
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Probiotic Induce Macrophage Cytokine Production via Activation of
Probiotic Induce Macrophage Cytokine Production via Activation of

... DNA binding [26], reported that STAT3have two isoform STAT-3a (86 kDa) and STAT-3b (79 kDa). Biethahn et al., demonstrated that transcriptional activation of STAT-3 was regulated by phosphorylation at Tyrosine 705 and Serine 727 in macrophages via the Mitogen-activated protein kinases (MAPKs). It is ...
obstructive sleep Apnea and the immune system
obstructive sleep Apnea and the immune system

... Detection of immune cell signaling factors in the circulation, such as IL-1 beta, TNF-alpha or its receptor, and/or IL-6, have been reported in patients with narcolepsy and sleep apnea who are affected by excessive daytime sleepiness.16 It is still speculative how sleep deprivation may perpetuate di ...
Innate Immunity Underlies Symbiotic Relationships
Innate Immunity Underlies Symbiotic Relationships

... mainly related to oral immunization with different antigens and is used in context of vaccination or treatment of some diseases. Modern publications most commonly use term “mucosal immunity” covering a wide range of issues considering not only relationships with commensal microbes, but also infectio ...
Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?
Enterovirus Infection and Type 1 Diabetes: Closing in on a Link?

... also be mere secondary players in a complex immune process that ends with the destruction of b-cells. Supporting the concept of a potential viral presence that would contribute to the demise of b-cells, elevated levels of MHC-I have been found in donors with T1D, consistent with a possible virus-ind ...
research infrastructure - The American Society of Hematology
research infrastructure - The American Society of Hematology

Prevention of HBV infections: vaccination and its limitations
Prevention of HBV infections: vaccination and its limitations

... • in certain risk groups boosters may be used to provide reassurance of protective immunity ...
A. Anemia caused by decreased production of red blood cells
A. Anemia caused by decreased production of red blood cells

... Hepcidine binds the feroportin molecules from the membrane, molecules responsible for iron export, leading to their internalization and intracellular degradation. In this way iron stuck in macrophages and can not be used for Hb synthesis. ...
Molecular mechanism of the migration of neutrophils in liver
Molecular mechanism of the migration of neutrophils in liver

... [46, 47]. IL-8 is a major chemokine for neutrophils which is largely responsible for the recruitment of these cells at sites of inflammation/ infection in human [48]. In a whole-blood conditions experiment, high concentration HMGB1 also can significantly increased IL-8 production. HMGB1-induced incr ...
PD-1 Cancer Immunotherapy
PD-1 Cancer Immunotherapy

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Molecular mimicry

Molecular mimicry is defined as the theoretical possibility that sequence similarities between foreign and self-peptides are sufficient to result in the cross-activation of autoreactive T or B cells by pathogen-derived peptides. Despite the promiscuity of several peptide sequences which can be both foreign and self in nature, a single antibody or TCR (T cell receptor) can be activated by even a few crucial residues which stresses the importance of structural homology in the theory of molecular mimicry. Upon the activation of B or T cells, it is believed that these ""peptide mimic"" specific T or B cells can cross-react with self-epitopes, thus leading to tissue pathology (autoimmunity). Molecular mimicry is a phenomenon that has been just recently discovered as one of several ways in which autoimmunity can be evoked. A molecular mimicking event is, however, more than an epiphenomenon despite its low statistical probability of occurring and these events have serious implications in the onset of many human autoimmune disorders. In the past decade the study of autoimmunity, the failure to recognize self antigens as ""self,"" has grown immensely. Autoimmunity is a result of a loss of immunological tolerance, the ability for an individual to discriminate between self and non-self. Growth in the field of autoimmunity has resulted in more and more frequent diagnosis of autoimmune diseases. Consequently, recent data show that autoimmune diseases affect approximately 1 in 31 people within the general population. Growth has also led to a greater characterization of what autoimmunity is and how it can be studied and treated. With an increased amount of research, there has been tremendous growth in the study of the several different ways in which autoimmunity can occur, one of which is molecular mimicry. The mechanism by which pathogens have evolved, or obtained by chance, similar amino acid sequences or the homologous three-dimensional crystal structure of immunodominant epitopes remains a mystery.
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