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Domains of the Adenovirus E1A Protein Required for
... This Article is brought to you for free and open access by the Natural Sciences and Mathematics at WesScholar. It has been accepted for inclusion in Division III Faculty Publications by an authorized administrator of WesScholar. For more information, please contact [email protected], ...
... This Article is brought to you for free and open access by the Natural Sciences and Mathematics at WesScholar. It has been accepted for inclusion in Division III Faculty Publications by an authorized administrator of WesScholar. For more information, please contact [email protected], ...
Tcf3: a transcriptional regulator of axis induction in the early embryo
... Wnt signaling guides cell fate decisions in many physiological contexts, and the molecular nature of its signal transduction provides the Wnt pathway with the ability to have varied effects on cells. Although the stability of β-catenin is central to the activation of Wnt signaling target genes, Lef/ ...
... Wnt signaling guides cell fate decisions in many physiological contexts, and the molecular nature of its signal transduction provides the Wnt pathway with the ability to have varied effects on cells. Although the stability of β-catenin is central to the activation of Wnt signaling target genes, Lef/ ...
Solubility of recombinant Src homology 2 domains expressed in E
... by TANGO, we generated TFV → GYT and FV → YT mutants of the TSAd-90-188-PHRD and TSAd-90-188-PAAS constructs, and compared their expression to that of the ALX SH2 domain. These constructs were chosen, as they contained the shortest flanking sequences compared to the original TSAd 1-TD construct, and ...
... by TANGO, we generated TFV → GYT and FV → YT mutants of the TSAd-90-188-PHRD and TSAd-90-188-PAAS constructs, and compared their expression to that of the ALX SH2 domain. These constructs were chosen, as they contained the shortest flanking sequences compared to the original TSAd 1-TD construct, and ...
The role of ABA and MAPK signaling pathways in
... seed germination and stomatal movement in 13 out of 15 ABC transporter gene knockout mutants (atabcg29–atbcg41). AtABCG40 is also a plasma membrane protein and expressed primarily in leaves of young plantlets and in primary and lateral roots. In leaves, expression was the highest in guard cells. The ...
... seed germination and stomatal movement in 13 out of 15 ABC transporter gene knockout mutants (atabcg29–atbcg41). AtABCG40 is also a plasma membrane protein and expressed primarily in leaves of young plantlets and in primary and lateral roots. In leaves, expression was the highest in guard cells. The ...
Negative Regulation of Rho Signaling by Insulin and Its
... he Rho family of small GTPases are well-recognized intracellular signaling proteins that act as molecular switches to control actin cytoskeleton organization in many cell types, including smooth muscle (1– 4). In addition, RhoA-dependent signaling pathway controls important vascular smooth muscle ce ...
... he Rho family of small GTPases are well-recognized intracellular signaling proteins that act as molecular switches to control actin cytoskeleton organization in many cell types, including smooth muscle (1– 4). In addition, RhoA-dependent signaling pathway controls important vascular smooth muscle ce ...
Solid-phase classical complement activation by C
... immunodiffusion, CRP–C1q interaction was observed in serum samples with high CRP concentrations. We propose that the underlying mechanism depends on fluid-phase interaction between C1q and CRP. This might constitute another level of complement regulation, which has implications for systemic lupus er ...
... immunodiffusion, CRP–C1q interaction was observed in serum samples with high CRP concentrations. We propose that the underlying mechanism depends on fluid-phase interaction between C1q and CRP. This might constitute another level of complement regulation, which has implications for systemic lupus er ...
The HSP90-SGT1 Chaperone Complex for NLR
... may disrupt its packing conformation, resulting in an open and active state. Several autoactive or autoimmune mutants of plant NLR proteins contain mutations in this pocket (10, 108, 117). Because similar mutations in human NOD2 cause autoimmune phenotypes, this domain likely represents a conserved ...
... may disrupt its packing conformation, resulting in an open and active state. Several autoactive or autoimmune mutants of plant NLR proteins contain mutations in this pocket (10, 108, 117). Because similar mutations in human NOD2 cause autoimmune phenotypes, this domain likely represents a conserved ...
hematopoietic stem cells: to be or notch to be
... During embryonic development, specification of the different tissues runs in parallel with the progressive restriction of the stem cell potential. However, significant pools of stem cells are found in the adult tissues that are continuously renewed during lifetime, such as blood or intestine. For ma ...
... During embryonic development, specification of the different tissues runs in parallel with the progressive restriction of the stem cell potential. However, significant pools of stem cells are found in the adult tissues that are continuously renewed during lifetime, such as blood or intestine. For ma ...
a va i l a b l e a t... w w w. e l s e v i e...
... previously reported sites. Proteolysis requires Kuzbaniandependent metalloprotease activity and a novel thiol-sensitive aspartyl protease activity. In addition, we show that Delta proteolysis differs from the RIP mechanism by two fundamental criteria: 1) TM-domain processing of Delta is not sensitiv ...
... previously reported sites. Proteolysis requires Kuzbaniandependent metalloprotease activity and a novel thiol-sensitive aspartyl protease activity. In addition, we show that Delta proteolysis differs from the RIP mechanism by two fundamental criteria: 1) TM-domain processing of Delta is not sensitiv ...
dravhandling-hafte - DUO
... fusion with a target membrane and via passage along tubules that might connect to acceptor compartments (Vitale and Denecke 1999). ER exit sites (ERES), also known as transitional ER (tER), are specialized domains of ER membranes responsible for the directed export of secretory cargo (Palade 1975). ...
... fusion with a target membrane and via passage along tubules that might connect to acceptor compartments (Vitale and Denecke 1999). ER exit sites (ERES), also known as transitional ER (tER), are specialized domains of ER membranes responsible for the directed export of secretory cargo (Palade 1975). ...
Signaling pathways in myocyte hypertrophy. Role of GATA4
... Transcription factor GATA4 was studied to identify the mechanism leading to increased gene expression of BNP. In BNP promoter, GATA4 binds to cis elements mediating hypertrophic response. Eliminating GATA4 binding by using the decoy approach, basal BNP gene expression was reduced. To identify mechan ...
... Transcription factor GATA4 was studied to identify the mechanism leading to increased gene expression of BNP. In BNP promoter, GATA4 binds to cis elements mediating hypertrophic response. Eliminating GATA4 binding by using the decoy approach, basal BNP gene expression was reduced. To identify mechan ...
Glycophorin C Content of Human Erythrocyte
... A, B, and C have recently been isolated and characterized.’.’ It has been shown that these three sialoglycoproteins are products of three distinct gene^.^.^ Erythrocytes that lack either glycoprotein A or B or both these sialoglycoproteins have normal discoid shape and normal membrane material prope ...
... A, B, and C have recently been isolated and characterized.’.’ It has been shown that these three sialoglycoproteins are products of three distinct gene^.^.^ Erythrocytes that lack either glycoprotein A or B or both these sialoglycoproteins have normal discoid shape and normal membrane material prope ...
Detergent-Insoluble Membrane Compartment CD20 Required for Its
... were not destroyed by protease digestion, these results, together with those in Figure 2, confirm their intracellular location. Data from extracellular protease digestion analyses support a four-TM domain topology with a single extracellular loop between TM3 and TM4, in agreement with the hydropathy ...
... were not destroyed by protease digestion, these results, together with those in Figure 2, confirm their intracellular location. Data from extracellular protease digestion analyses support a four-TM domain topology with a single extracellular loop between TM3 and TM4, in agreement with the hydropathy ...
Vertebrate limb development--the early stages in chick - ICB-USP
... (Fgf8 is never expressed). A strikingly similar limb phenotype was observed more recently in the knockout of FGF receptor 2-IIIb [12•], for which FGF10 had previously been suggested to be the major ligand [13]. Mice deficient for this particular receptor isoform show agenesis of limbs but, surprisin ...
... (Fgf8 is never expressed). A strikingly similar limb phenotype was observed more recently in the knockout of FGF receptor 2-IIIb [12•], for which FGF10 had previously been suggested to be the major ligand [13]. Mice deficient for this particular receptor isoform show agenesis of limbs but, surprisin ...
functional and structural complexity of signal transduction via g
... diverging and converging transduction steps at each coupling interface. The recent realization that classical signaling pathways are intimately intertwined with growth-factor–signaling cascades adds another level of complexity. Elaborate studies have significantly enhanced our knowledge of the funct ...
... diverging and converging transduction steps at each coupling interface. The recent realization that classical signaling pathways are intimately intertwined with growth-factor–signaling cascades adds another level of complexity. Elaborate studies have significantly enhanced our knowledge of the funct ...
Drosophila center divider Gene Is Expressed in CNS Midline Cells
... understanding how master regulatory proteins control cell lineage development is identification of the genes that are transcriptional targets of these regulatory proteins. Additional insight into lineage-specific developm ent follows through understanding of the role of the target genes. Enhancer tr ...
... understanding how master regulatory proteins control cell lineage development is identification of the genes that are transcriptional targets of these regulatory proteins. Additional insight into lineage-specific developm ent follows through understanding of the role of the target genes. Enhancer tr ...
CHAPTER 3: Early tissue patterning is recreated by MEFs in... Figure 5: Osteogenic and chondrogenic differentiation of MEFs cultured in
... Moreover, a dose-response inhibitory effect on the 3D-bilateral structure development can be observed when diluted concentrations of Staurosporine are added to the cultures (Figure 2 F). These results indicate that during this morphogenetic event the cell density increases not only by contraction bu ...
... Moreover, a dose-response inhibitory effect on the 3D-bilateral structure development can be observed when diluted concentrations of Staurosporine are added to the cultures (Figure 2 F). These results indicate that during this morphogenetic event the cell density increases not only by contraction bu ...
CHARACTERIZATION OF THE ROLE OF PSEUDOMONAS
... multiple strains of P. syringae suggests that it plays an important role in virulence, no function has yet been associated with HopAF1. We generated a tertiary structural prediction for HopAF1, which suggests that HopAF1 is structurally related to bacterial deamidases. Deamidation, the irreversible ...
... multiple strains of P. syringae suggests that it plays an important role in virulence, no function has yet been associated with HopAF1. We generated a tertiary structural prediction for HopAF1, which suggests that HopAF1 is structurally related to bacterial deamidases. Deamidation, the irreversible ...
Biochemical Journal
... knowledge of MAPK biological functions may be due at least in part to the availability of inhibitors for the several MAPK families that usually function as parallel pathways in any given cell. In the present review, we provide an overview of the p38 MAPK pathway, which is strongly activated by stres ...
... knowledge of MAPK biological functions may be due at least in part to the availability of inhibitors for the several MAPK families that usually function as parallel pathways in any given cell. In the present review, we provide an overview of the p38 MAPK pathway, which is strongly activated by stres ...
The functional diversity of essential genes required for mammalian
... the role of some genes in early-gestational cardiac development. For example, Wnt signaling ligands possess high protein sequence homology, overlapping expression domains and overlapping functions during early cardiac development which compensates for the absence of each other (Cohen et al., 2008), ...
... the role of some genes in early-gestational cardiac development. For example, Wnt signaling ligands possess high protein sequence homology, overlapping expression domains and overlapping functions during early cardiac development which compensates for the absence of each other (Cohen et al., 2008), ...
circadian clock Drosophila transcriptional regulator in the as a
... Rutila et al. 1998; Blau and Young 1999). However, there are some disadvantages with this strategy when we apply it at a genome-wide level. In particular, mutants are not available for many candidate genes, and even if they are, many of these mutants are lethal during development (Blau and Young 199 ...
... Rutila et al. 1998; Blau and Young 1999). However, there are some disadvantages with this strategy when we apply it at a genome-wide level. In particular, mutants are not available for many candidate genes, and even if they are, many of these mutants are lethal during development (Blau and Young 199 ...
- Wiley Online Library
... nutrient limitation, suggesting the beneficial effect of DR is, at least in part, mediated by TOR (Kapahi et al., 2004; Hansen et al., 2007). Similar observations have also been reported in yeast (Kaeberlein et al., 2005). It has been shown in many organisms that, in response to nutrient or energy d ...
... nutrient limitation, suggesting the beneficial effect of DR is, at least in part, mediated by TOR (Kapahi et al., 2004; Hansen et al., 2007). Similar observations have also been reported in yeast (Kaeberlein et al., 2005). It has been shown in many organisms that, in response to nutrient or energy d ...
PDF
... signal but also on cellular competence, i.e. the ability of cells to receive and respond to inductive signals. These properties are temporally and spatially regulated in a coordinated manner, ensuring that tissues are induced at the right time and in the proper location. One important form of compet ...
... signal but also on cellular competence, i.e. the ability of cells to receive and respond to inductive signals. These properties are temporally and spatially regulated in a coordinated manner, ensuring that tissues are induced at the right time and in the proper location. One important form of compet ...
The transcription factor FoxB mediates temporal
... signal but also on cellular competence, i.e. the ability of cells to receive and respond to inductive signals. These properties are temporally and spatially regulated in a coordinated manner, ensuring that tissues are induced at the right time and in the proper location. One important form of compet ...
... signal but also on cellular competence, i.e. the ability of cells to receive and respond to inductive signals. These properties are temporally and spatially regulated in a coordinated manner, ensuring that tissues are induced at the right time and in the proper location. One important form of compet ...
Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK
... Rac, a small G-protein that binds and activates p21cdc42\rac1activated serine\threonine kinase (PAK) [29]. PAK-3 has recently been shown to phosphorylate Raf-1 on serine-338, one of the sites whose phosphorylation is required for activation [36]. The other site is tyrosine-341, which is targeted by ...
... Rac, a small G-protein that binds and activates p21cdc42\rac1activated serine\threonine kinase (PAK) [29]. PAK-3 has recently been shown to phosphorylate Raf-1 on serine-338, one of the sites whose phosphorylation is required for activation [36]. The other site is tyrosine-341, which is targeted by ...
Hedgehog signaling pathway
![](https://en.wikipedia.org/wiki/Special:FilePath/Denticlebands.png?width=300)
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.