![Ca Signaling11](http://s1.studyres.com/store/data/008315988_1-636fc4168e97957623a84f0cb446f2b7-300x300.png)
Ca Signaling11
... - Calcineurin dephos cyto NFAT transport into nucleus. - W/o Ca2+-activated calcineurin activity, NFAT becomes rephos by GSK and re-exported to cytoplasm. ...
... - Calcineurin dephos cyto NFAT transport into nucleus. - W/o Ca2+-activated calcineurin activity, NFAT becomes rephos by GSK and re-exported to cytoplasm. ...
The Drosophila Planar Polarity Proteins Inturned and
... required for either or both of the subcellular locations where Mwh accumulated, we immunolocalized Mwh in cells mutant for the PCP genes fz, Vang and stan and the PPE genes fy, frtz and in. We first considered the proximal accumulation seen just prior to and at hair initiation (32 hrs). The accumula ...
... required for either or both of the subcellular locations where Mwh accumulated, we immunolocalized Mwh in cells mutant for the PCP genes fz, Vang and stan and the PPE genes fy, frtz and in. We first considered the proximal accumulation seen just prior to and at hair initiation (32 hrs). The accumula ...
Proteins that contain a functional Z-DNA
... sequences. The Za domain may thus be used to target ADAR1p150 to sequences with the potential to form Z-RNA for selective editing (11). Z-DNA or Z-RNA comprises an alternative, higher energy conformation of DNA or RNA, respectively, that preferentially occurs within sequences containing alternating ...
... sequences. The Za domain may thus be used to target ADAR1p150 to sequences with the potential to form Z-RNA for selective editing (11). Z-DNA or Z-RNA comprises an alternative, higher energy conformation of DNA or RNA, respectively, that preferentially occurs within sequences containing alternating ...
- Wiley Online Library
... responses mediated by the fungal protein ethylene-inducing xylanase (EIX). The movement of FYVE-positive endosomes before and after EIX application was examined using spinning disc confocal microscopy. We found that while FYVE-positive endosomes generally observe a random movement pattern, following ...
... responses mediated by the fungal protein ethylene-inducing xylanase (EIX). The movement of FYVE-positive endosomes before and after EIX application was examined using spinning disc confocal microscopy. We found that while FYVE-positive endosomes generally observe a random movement pattern, following ...
Localization of Leptin Binding Domain in the Leptin Receptor
... OB-Rb with the glycan-phosphatidylinositol signal sequence from the human placenta alkaline phosphatase (HPAP-S peptide) as described previously (Lin et al., 1990). The S-D(867–1165) mutant was generated by exchanging the extracellular domain of the S(420–496)to-(500–632) mutant and the D(867–1165) ...
... OB-Rb with the glycan-phosphatidylinositol signal sequence from the human placenta alkaline phosphatase (HPAP-S peptide) as described previously (Lin et al., 1990). The S-D(867–1165) mutant was generated by exchanging the extracellular domain of the S(420–496)to-(500–632) mutant and the D(867–1165) ...
Supplementary Data - Institute of Cancer Research
... The kinetics of IMD pathway activation in response to Gram-negative bacteria can be assessed by monitoring the expression of the antibacterial peptide gene Diptericin, a target of the NF-κB-like transcription factor Relish. Drosophila mounts differential responses to identical concentrations of live ...
... The kinetics of IMD pathway activation in response to Gram-negative bacteria can be assessed by monitoring the expression of the antibacterial peptide gene Diptericin, a target of the NF-κB-like transcription factor Relish. Drosophila mounts differential responses to identical concentrations of live ...
Article (Published version)
... in the frog neural plate (Brewster et al., 1998; Ruiz i Altaba, 1998). In zebrafish, it can act as both an activator and a repressor in vivo, and can cooperate with or inhibit Gli1 functions in vitro (Tyurina et al., 2005). Mouse mutants for Gli3 display neural tube closure defects and polydactyly ( ...
... in the frog neural plate (Brewster et al., 1998; Ruiz i Altaba, 1998). In zebrafish, it can act as both an activator and a repressor in vivo, and can cooperate with or inhibit Gli1 functions in vitro (Tyurina et al., 2005). Mouse mutants for Gli3 display neural tube closure defects and polydactyly ( ...
PDZ proteins retain and regulate membrane transporters in
... interferes with the surface expression of CFTR. Indeed, overexpression of GOPC (or CAL) in CFTR-expressing COS-7 cells reduces cAMP-activated Cl⫺ currents by decreasing the number of channels in the plasma membrane. The reduced surface expression of CFTR is caused both by a decreased rate of inserti ...
... interferes with the surface expression of CFTR. Indeed, overexpression of GOPC (or CAL) in CFTR-expressing COS-7 cells reduces cAMP-activated Cl⫺ currents by decreasing the number of channels in the plasma membrane. The reduced surface expression of CFTR is caused both by a decreased rate of inserti ...
THE RDOA-DEPENDENT PHOSPHOPROTEOME PROFILE OF Salmonella enterica
... (PerkinElmer) gave the highest yield, the majority of which were phosphoproteins. These studies also showed that western blots using phospho-specific antibodies were more sensitive than phosphoprotein-specific fluorescent stain ProQ Diamond in detecting phosphoproteins. The phosphoproteome profile o ...
... (PerkinElmer) gave the highest yield, the majority of which were phosphoproteins. These studies also showed that western blots using phospho-specific antibodies were more sensitive than phosphoprotein-specific fluorescent stain ProQ Diamond in detecting phosphoproteins. The phosphoproteome profile o ...
The Sec61p Complex Mediates the Integration of a Membrane
... in SDS and thus cause the more compact protein to run faster in SDS gels. With the 61-mer, most of the chains were found in the membrane pellet (P) at neutral (lanes 9 and 10 versus 11 and 12), but not at alkaline pH (lanes 13 and 14 versus 15 and 16). As with the 54-mer, internal crosslinks appeare ...
... in SDS and thus cause the more compact protein to run faster in SDS gels. With the 61-mer, most of the chains were found in the membrane pellet (P) at neutral (lanes 9 and 10 versus 11 and 12), but not at alkaline pH (lanes 13 and 14 versus 15 and 16). As with the 54-mer, internal crosslinks appeare ...
Late Endosomal/Lysosomal Targeting and Lack of Recycling of the
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
... endothelin receptors, the mode of internalization has been analyzed only for the ETA receptor. In stably transfected Chinese hamster ovary (CHO) cells, the receptor was found to reside in caveolae and to be internalized after binding of ET1 (Chun et al., 1994). Because a significant portion of the i ...
Drosophila
... and performed three biological replicates for each sample. For both Ubx-YFP and Hth-YFP, genome-wide binding was assayed using chromatin samples from 0–16 hr embryos and 3rd larval instar haltere imaginal discs; for Hth-YPF we also assayed binding in 3rd larval instar wing imaginal disc chromatin. F ...
... and performed three biological replicates for each sample. For both Ubx-YFP and Hth-YFP, genome-wide binding was assayed using chromatin samples from 0–16 hr embryos and 3rd larval instar haltere imaginal discs; for Hth-YPF we also assayed binding in 3rd larval instar wing imaginal disc chromatin. F ...
PDF
... Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2–/– and Rxra–/– mouse embryos to investigate the role of retinoic acid (RA) signaling in this developmental process. The heart phenotypes of Raldh2 and Rxra mutants are very si ...
... Epicardial signaling and Rxra are required for expansion of the ventricular myocardial compact zone. Here, we examine Raldh2–/– and Rxra–/– mouse embryos to investigate the role of retinoic acid (RA) signaling in this developmental process. The heart phenotypes of Raldh2 and Rxra mutants are very si ...
PDF
... developmental processes are under elaborate control of multiple families of signaling molecules, including bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), Shh and Wnt proteins (Tummers and Thesleff, 2009). The importance of canonical Wnt signaling in odontogenesis has been well ...
... developmental processes are under elaborate control of multiple families of signaling molecules, including bone morphogenetic proteins (BMPs), fibroblast growth factors (FGFs), Shh and Wnt proteins (Tummers and Thesleff, 2009). The importance of canonical Wnt signaling in odontogenesis has been well ...
T Molecular Basis of Muscle Structure C 12
... relatively unaffected, but the mutations lead to fiber hypercontraction and rapid breakdown of the sarcomere subsequent to eclosion. In addition, both mutations interfere with the normal accumulation of the IFM-specific protein flightin.16 As discussed below, the myosin rod-flightin interaction is e ...
... relatively unaffected, but the mutations lead to fiber hypercontraction and rapid breakdown of the sarcomere subsequent to eclosion. In addition, both mutations interfere with the normal accumulation of the IFM-specific protein flightin.16 As discussed below, the myosin rod-flightin interaction is e ...
ABSTRACT Title of Document:
... germline transmission have only been verified in the mouse. Promising results with hESCs and adult stem cells have nurtured hope for their potential use in regenerative medicine. However, such an application is still far from reality since substantial research is required to elucidate the yet unknow ...
... germline transmission have only been verified in the mouse. Promising results with hESCs and adult stem cells have nurtured hope for their potential use in regenerative medicine. However, such an application is still far from reality since substantial research is required to elucidate the yet unknow ...
NF-kB as a primary regulator of the stress response
... 181, and that IKK1 does not undergo induced phosphorylation at the corresponding sites nor is it required for IKK activity. Because NIK and MEKK-1 are activated by discrete stimuli, these studies provide further evidence supporting the IKK complex as being a central juncture of the NF-kB activation ...
... 181, and that IKK1 does not undergo induced phosphorylation at the corresponding sites nor is it required for IKK activity. Because NIK and MEKK-1 are activated by discrete stimuli, these studies provide further evidence supporting the IKK complex as being a central juncture of the NF-kB activation ...
MICROSTRUCTURE OF PROTEIN BODIES IN MARAMA BEAN SPECIES
... protein bodies of marama bean. Globoids constitute storage sites for seed phosphorus deposited as insoluble phytate in protein bodies (Martinez, 1979). Spherical globoids are the most common inclusion reported in protein bodies of legumes like peanuts (Young et al., 2004), walnuts and hazelnuts (Lo ...
... protein bodies of marama bean. Globoids constitute storage sites for seed phosphorus deposited as insoluble phytate in protein bodies (Martinez, 1979). Spherical globoids are the most common inclusion reported in protein bodies of legumes like peanuts (Young et al., 2004), walnuts and hazelnuts (Lo ...
Cloning and developmental expression of Sna, a murine homologue
... D-V axis (Ray et al., 1991), with peak levels in ventral regions initiating the expression of two genes, twist and snail, that are required for the formation and morphogenesis of mesoderm. Initially the twist and snail genes act in parallel pathways, since they are activated independently of each ot ...
... D-V axis (Ray et al., 1991), with peak levels in ventral regions initiating the expression of two genes, twist and snail, that are required for the formation and morphogenesis of mesoderm. Initially the twist and snail genes act in parallel pathways, since they are activated independently of each ot ...
Role of Smad4 (DPC4) inactivation in human cancer.
... • When inactive, it is located in the cytosol. It is translocated into the nucleus once activated • Loss of SMAD4 is associated with familial juvenile polyposis, and is often absent in ...
... • When inactive, it is located in the cytosol. It is translocated into the nucleus once activated • Loss of SMAD4 is associated with familial juvenile polyposis, and is often absent in ...
Gcm Target Genes Regulating Glial Development, Diversification
... ex/insitu.pl) and a previously published database (Kopczynski et al., 1998). Second, we identified Drosophila sequence homologs of vertebrate glial genes involved in glutamate neurotransmitter metabolism (a welldescribed role for vertebrate glia). We obtained cDNAs for each candidate glial gene (n ⫽ ...
... ex/insitu.pl) and a previously published database (Kopczynski et al., 1998). Second, we identified Drosophila sequence homologs of vertebrate glial genes involved in glutamate neurotransmitter metabolism (a welldescribed role for vertebrate glia). We obtained cDNAs for each candidate glial gene (n ⫽ ...
Integration of TP53, DREAM, MMB-FOXM1 and RB
... TP53 target genes since the overlap between any two expression profile studies is often quite small. The apparent discrepancies between studies have made it difficult to be confident in the regulation of a specific gene of interest across multiple studies. Furthermore, recent genome-wide analyses su ...
... TP53 target genes since the overlap between any two expression profile studies is often quite small. The apparent discrepancies between studies have made it difficult to be confident in the regulation of a specific gene of interest across multiple studies. Furthermore, recent genome-wide analyses su ...
PDF - Hormones.gr
... pathways, including Tor or mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase-I (PI3K-I)/PKB, Class III PI3K, Akt-PTENTSC1/2-Rheb-mTOR circuit, the Insulin Receptor and downstream targets, GTPases, calcium, and protein synthesis all play important roles in regulating autophagy.43 In ...
... pathways, including Tor or mammalian target of rapamycin (mTOR), phosphatidylinositol 3-kinase-I (PI3K-I)/PKB, Class III PI3K, Akt-PTENTSC1/2-Rheb-mTOR circuit, the Insulin Receptor and downstream targets, GTPases, calcium, and protein synthesis all play important roles in regulating autophagy.43 In ...
Farnesoid X Receptor Ligands Inhibit Vascular Smooth Muscle Cell
... PDGF-BB–stimulated conditions was abolished by 6ECDCA. In slight contrast, PDGF-BB–stimulated but not basal HASMC migration was inhibited by 6ECDCA. This difference most likely reflects that the RASMC cell line is already partially active in culture (as seen by low levels of basally expressed iNOS a ...
... PDGF-BB–stimulated conditions was abolished by 6ECDCA. In slight contrast, PDGF-BB–stimulated but not basal HASMC migration was inhibited by 6ECDCA. This difference most likely reflects that the RASMC cell line is already partially active in culture (as seen by low levels of basally expressed iNOS a ...
TGF-beta SIGNAL TRANSDUCTION - University of Colorado-MCDB
... of structurally related polypeptide growth factors, each capable of regulating a fascinating array of cellular processes including cell proliferation, lineage determination, differentiation, motility, adhesion, and death. Expressed in complex temporal and tissue-specific patterns, TGF-β and related ...
... of structurally related polypeptide growth factors, each capable of regulating a fascinating array of cellular processes including cell proliferation, lineage determination, differentiation, motility, adhesion, and death. Expressed in complex temporal and tissue-specific patterns, TGF-β and related ...
Hedgehog signaling pathway
![](https://en.wikipedia.org/wiki/Special:FilePath/Denticlebands.png?width=300)
The Hedgehog signaling pathway (or signalling pathway; see spelling differences) is a signaling pathway that transmits information to embryonic cells required for proper development. Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with the malfunction of this pathway include basal cell carcinoma.The Hedgehog signaling pathway is one of the key regulators of animal development and is present in all bilaterians. The pathway takes its name from its polypeptide ligand, an intercellular signaling molecule called Hedgehog (Hh) found in fruit flies of the genus Drosophila. Hh is one of Drosophila's segment polarity gene products, involved in establishing the basis of the fly body plan. The molecule remains important during later stages of embryogenesis and metamorphosis.Mammals have three Hedgehog homologues, DHH, IHH, and SHH, of which Sonic (SHH) is the best studied. The pathway is equally important during vertebrate embryonic development. In knockout mice lacking components of the pathway, the brain, skeleton, musculature, gastrointestinal tract and lungs fail to develop correctly. Recent studies point to the role of Hedgehog signaling in regulating adult stem cells involved in maintenance and regeneration of adult tissues. The pathway has also been implicated in the development of some cancers. Drugs that specifically target Hedgehog signaling to fight this disease are being actively developed by a number of pharmaceutical companies.