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Chap 3 - CRCBiologyY11
Chap 3 - CRCBiologyY11

... • The basic unit of any CHO is a sugar molecule called a monosaccharide, the most common being glucose. • Monosaccharide's combine in different ways to form polysaccharides. • A sugar that contains one or two monosaccharide’s are sometimes called simple sugars, while those with three or more are ref ...
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1 - u.arizona.edu

... 3. Regulation of pyruvate dehydrogenase (PDH) complex by allostery and by covalent modification Allosteric regulation - PDH allosterically inhibited by acetyl CoA (E2 component) and NADH (E3 component) - NADH provides electrons for respiratory (electron transport) chain (oxidative phosphorylation) ...
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... • Temporary molecular storage of energy as it is being transferred from exergonic catabolic reactions to cellular activities – muscle contraction, transport of substances across cell membranes, movement of structures within cells and movement of organelles ...
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... Significant  changes  in  temperature  and  pH=  protein  denatura2on   ...
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...  Active transport forms a H+ concentration gradient in the outer mitochondrial compartment  H+ follows its gradient through ATP synthase, which attaches a phosphate to ADP  Finally, oxygen accepts electrons and combines with H+, forming water ...
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... Glucose enters the cell, and while in the cytoplasm, it is broken down into two 3-carbon molecules called pyruvic acid. Although the cell uses some ATP to begin glycolysis, the overall process produces more ATP than was used to initiate it. For each molecule of glucose that enters glycolysis, a net ...
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... • A 2-carbon unit Acetyl-CoA is added to the cycle • And two CO2 molecules leave (but they are different carbons…) • During the course of changes in the carbon skeleton and its oxidation state • And the transfer of energy to form GTP (aka. the “Canadian $”) and reducing power, as NADH and FADH2 • It ...
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... Most of the steps are same as b-oxidation in mitochondria except that the first dehydrogenase is not linked to ETC in proxisomes. Electrons from the first reaction are transferred directly to O2 producing p hydrogen peroxide. Peroxisomal enzymes are up-regulated when fat rich diets are consumed. Gen ...
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Oxidative phosphorylation



Oxidative phosphorylation (or OXPHOS in short) is the metabolic pathway in which the mitochondria in cells use their structure, enzymes, and energy released by the oxidation of nutrients to reform ATP. Although the many forms of life on earth use a range of different nutrients, ATP is the molecule that supplies energy to metabolism. Almost all aerobic organisms carry out oxidative phosphorylation. This pathway is probably so pervasive because it is a highly efficient way of releasing energy, compared to alternative fermentation processes such as anaerobic glycolysis.During oxidative phosphorylation, electrons are transferred from electron donors to electron acceptors such as oxygen, in redox reactions. These redox reactions release energy, which is used to form ATP. In eukaryotes, these redox reactions are carried out by a series of protein complexes within the inner membrane of the cell's mitochondria, whereas, in prokaryotes, these proteins are located in the cells' intermembrane space. These linked sets of proteins are called electron transport chains. In eukaryotes, five main protein complexes are involved, whereas in prokaryotes many different enzymes are present, using a variety of electron donors and acceptors.The energy released by electrons flowing through this electron transport chain is used to transport protons across the inner mitochondrial membrane, in a process called electron transport. This generates potential energy in the form of a pH gradient and an electrical potential across this membrane. This store of energy is tapped by allowing protons to flow back across the membrane and down this gradient, through a large enzyme called ATP synthase; this process is known as chemiosmosis. This enzyme uses this energy to generate ATP from adenosine diphosphate (ADP), in a phosphorylation reaction. This reaction is driven by the proton flow, which forces the rotation of a part of the enzyme; the ATP synthase is a rotary mechanical motor.Although oxidative phosphorylation is a vital part of metabolism, it produces reactive oxygen species such as superoxide and hydrogen peroxide, which lead to propagation of free radicals, damaging cells and contributing to disease and, possibly, aging (senescence). The enzymes carrying out this metabolic pathway are also the target of many drugs and poisons that inhibit their activities.
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