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nutrition, metabolism, and body temperature
nutrition, metabolism, and body temperature

... are burned for energy depends on a number of factors: – 1.The all-or-none rule: • All amino acids needed to make a particular protein must be present in a cell at the same time and in sufficient amounts for the protein to be made • If one is missing, the protein cannot be made • Because essential am ...
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ch 9 Cellular_Respiration

... • 2. Citric Acid Cycle (Kreb’s Cycle)– pyruvate derivative (acetyl CoA) to CO2 – Mitochondrial matrix ...
Metabolism of amino acids
Metabolism of amino acids

... Amino nitrogen released from carbon sceletons of AAs can be transported in blood as a) NH4+ physiologically up to 35 µmol/l (NH3 + H + b) alanine ...
METABOLISM OF CARBOHYDRATES: GLYCOLYSIS
METABOLISM OF CARBOHYDRATES: GLYCOLYSIS

... enzyme lactase, which cleaves lactose into glucose and galactose. Microorganisms in the colon ferment undigested lactose to lactic acid generating methane (CH4) and hydrogen gas (H2). The gas produced creates the uncomfortable feeling of gut distention and the annoying problem of flatulence. The lac ...
Respiratory chain is the most productive pathway to make ATP
Respiratory chain is the most productive pathway to make ATP

... In the inner membrane there are four immobile enzyme complexes designated as I, II, III and IV. Inner membrane also has enzymes capable to move from one complex to another named coenzyme Q and cytochrome c. The transfer of electrons along the respiratory chain is accompanied by outward pumping of pr ...
Principles of BIOCHEMISTRY - Illinois State University
Principles of BIOCHEMISTRY - Illinois State University

... • The brain relies almost solely on glucose for energy needs • The liver participates in the interconversions of all types of metabolic fuels: carbohydrates, amino acids and fatty acids • Products of digestion pass immediately to the liver for metabolism or redistribution • The liver regulates distr ...
pyruvate
pyruvate

... The two products of the Pdh complex, NADH and acetyl-CoA, are negative allosteric effectors on Pdh-a, the non-phosphorylated, active form of Pdh. These effectors (see Figure 13 Lecture ppt) reduce the affinity of the enzyme for pyruvate, thus limiting the flow of carbon through the Pdh complex. In a ...
The Citric Acid Cycle
The Citric Acid Cycle

... citric acid cycle, generating three NADH, one FADH2, and one ATP (by substrate-level phophorylation). • Intermediates of citric acid cycle are drawn off to synthesize many other biomolecules, including fatty acids, steroids, amino acids, heme, pyrimidines, and glucose. ...
Exam2_2012 final key - (canvas.brown.edu).
Exam2_2012 final key - (canvas.brown.edu).

... A) The brain prefers glucose as an energy source, but can use ketone bodies. B) Muscle cannot use fatty acids as an energy source. C) The brain exports ketone bodies as fuels for other tissues. D) Fatty acids cannot be used as an energy source in humans because humans lack the enzymes of the glyoxyl ...
Enter Legible BANNER ID: B 0 0 __ __ __ __ __ __ DO NOT WRITE
Enter Legible BANNER ID: B 0 0 __ __ __ __ __ __ DO NOT WRITE

... A) The brain prefers glucose as an energy source, but can use ketone bodies. B) Muscle cannot use fatty acids as an energy source. C) The brain exports ketone bodies as fuels for other tissues. D) Fatty acids cannot be used as an energy source in humans because humans lack the enzymes of the glyoxyl ...


... In energy sensing, high levels of ATP inhibit glycolysis by inhibition of PFK-1. This prevents the generation of more ATP than is needed. High levels of AMP or ADP activate PFK-1, causing glycolysis to occur to replenish the ATP. The bis phosphatase is regulated in an inverse manner, except that it ...
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Sugar

... Figure 9-11(b-d) Structures of bioactive products produced ...
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Slide 1

... used for this process to take place. • Catabolism: The breakdown of molecules into smaller units. Energy is released in this process. – Ex: Glucose catabolism results in the release of CO2 and H2O ...
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Problem Set# 3

... 3. Which is true of the intermediate step of metabolism? a. CO2 and ATP are released during the process b. A multienzyme complex removes a carboxyl group, transfers electrons to NAD+, and attaches a coenzyme. c. NAD+ is rejuvenated so glycolysis can continue d. Lactate is produced to rejuvenate free ...
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question Examination questions: Digestion and intermediary

... Expected knowledge of metabolic pathways: review of substrates, important intermediates and products, the importance of each pathway, its regulation and its interconnection with intermediary metabolism. The pathways will not be tested in details as required in the module Cellular Basis of Medicine. ...
Amino Acids Objectives
Amino Acids Objectives

... from the breaking down of muscle (protein catabolism) are oxidized and nitrogen is used for urea. Enzymes of urea cycle are induced. Short term regulation – Carbamoyl phosphate synthetase I is allosterically activated 5-10 fold by N-acetylglutamate. Synthesis of N-acetylglutamate depends on the avai ...
Fatty Acid Synthesis
Fatty Acid Synthesis

... produce: • Phosphatidylinositol (PI) in one step – 2-8% in animal membrane – Breakdown to form inositol-1,4,5-triphosphate & DAG (second messengers) ...
Triosephosphate Isomerase (T6258) - Datasheet - Sigma
Triosephosphate Isomerase (T6258) - Datasheet - Sigma

... α-glycerophosphate dehydrogenase 3-phosphoglyceric phosphokinase glyceraldehyde-3-phosphate dehydrogenase aldolase L-lactic dehydrogenase pyruvate kinase Precautions and Disclaimer This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet ...
Biology`s Gasoline: Oxidation of Fatty Acids Fats: our unpopular best
Biology`s Gasoline: Oxidation of Fatty Acids Fats: our unpopular best

... or an intermediate that is not part of the central pathway into one that is. Often a separate enzyme will help the process, allowing a new molecule to also enter an old pathway. We saw this in glycolysis of several sugars that are not glucose; the strategy there is to modify that sugar into either g ...
Nitrogen Metabolism Overview
Nitrogen Metabolism Overview

... the same as the first step of fatty acid  oxidation. The fourth step involves an ATP‐ dependent carboxylation, the fifth step is a  hydration, and the last step is a cleavage  reaction to give products. Draw the  intermediates of leucine degradation. ...
Keigo Tanaka Chapter 9 – Cellular Respiration: Harvesting
Keigo Tanaka Chapter 9 – Cellular Respiration: Harvesting

... ADP, forming ATP (substrate-level phosphorylation) and succinate 6. Two hydrogens are transferred to FAD, forming FADH2 and oxidizing succinate to fumarate 7. The addition of a water molecule rearranges bonds in the substrate forming malate 8. The substrate is oxidized, reducing NAD+ to NADH and reg ...
Oxidative decarboxylation of pyruvate
Oxidative decarboxylation of pyruvate

... Pyruvate formed in the aerobic conditions undergoes conversion to acetyl CoA by pyruvate dehydrogenase complex. Pyruvate dehydrogenase complex is a bridge between glycolysis and aerobic metabolism – citric acid cycle. Pyruvate dehydrogenase complex and enzymes of cytric acid cycle are located in the ...
Overview of Metabolism Chapter
Overview of Metabolism Chapter

... as some mobile electron carriers (ubiquinone and cytochrome c). Electrons are passed through the carriers, eventually ending up reducing O2 to form water. The energy released as the electrons flow through the chain is used to transport H+ (hydrogen ions [aka protons]) out of the mitochondria. The en ...
HERE
HERE

... As a result, there is an increase in Anaerobic Glycolysis, leading to an increase in cellular levels of Lactate, which consequently can, in some cases result in intracellular acidosis ...
Acyl-CoA
Acyl-CoA

... - Triglycerides (or triacylglycerols) are fatty acid esters (usually with different fatty acid R groups) of glycerol—see §1.4! - Triglycerides are largely stored in the adipose tissue where they function as “high-energy” reservoirs—due to being more reduced (carry more electrons, or more hydrogens!) ...
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Glyceroneogenesis



Glyceroneogenesis is a metabolic pathway which synthesizes glycerol 3-phosphate or triglyceride from precursors other than glucose. Usually glycerol 3-phosphate is generated from glucose by glycolysis, but when glucose concentration drops in the cytosol, it is generated by another pathway called glyceroneogenesis. Glyceroneogenesis uses pyruvate, alanine, glutamine or any substances from the TCA cycle as precursors for glycerol 3-phophate. Phosphoenolpyruvate carboxykinase (PEPC-K), which is an enzyme that catalyses the decarboxylation of oxaloacetate to phosphoenolpyruvate is the main regulator for this pathway. Glyceroneogenesis can be observed in adipose tissue and also liver. It is a significant biochemical pathway which regulates cytosolic lipid levels. Intense suppression of glyceroneogenesis may lead to metabolic disorder such as type 2 diabetes.
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