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Innovation in Translational Medicine
Cell-Based Therapeutics: Medicine’s Next Pillar
CALIS
Medical Libraries
Yinchuan Ningxia
2013
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Cellular Engineering:
the Challenge of Controlling Cell’s Actions
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The Beauty of Cells
• Cells naturally perform
therapeutic tasks
• Cell behavior is exquisitely
selective
• Cells are special delivery
agents
• Cells can handle human
genetic variability
• Cells behaviors can be
engineered
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Killer Apps for Cell Therapy Will Address
Critical Unmet Needs of Human Disease
• Immune cells that seek
and destroy cancer
• Bacterial treatment for
Crohn’s disease
• Combination of
bacterial and
mammalian cell
therapeutics
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Roadblocks for Cell Transplants
S. J. Sharkis et al., Sci Transl Med 2012;4:127ps9-127ps9
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Published by AAAS
Challenges to Make Cell Therapeutics Safe
• Two major challenges – safety and efficacy
• The lifetimes of cells can be carefully
controlled
• US FDA will need well-defined safety criteria
for cell therapeutics for early movers to
invest in new companies
• Better odds in the therapeutic development
pipeline
Cell-based Therapeutics
The New Third Pillar of Medicine?
• A foundational science of
cellular engineering
• Key control modules
needed in the cellular
engineer’s toolbox
• Control over cell death via
safety switch mechanisms
• Ability to reprogram cell
communication
• Systematic strategies to
reshape cellular behaviors
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Potential Rational Engineering of
Therapeutic Cells
Now is the time for the
designers of cellular
therapeutics to take the
systematic steps to lay
the solid foundation for
future therapeutic
industries.
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Science Translational Medicine
Research from China
• Muscular Dystrophy
• Peking University 2012
• Cancer Leukemia
• CAS Institutes 2012
• Atherosclerosis
• BGI 2013
• Graft-Versus-Host Disease
• Guangzhou Medical College
2013
• Kidney Disease
• Shanghai Jiao Tong University
2013
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Science Signaling - Research from China
• Innate &Adaptive Immune Responses
•
CAS Laboratory of Infection and
Immunity 2012
• Parkinson’s Disease
•
University of Science & Technology
•
Soochow University 2012
• Avian Influenza
•
Multi Institutions 2012
• Squamous Cell Carcinoma
•
Shanghai Jiaotong University
•
Capital University of Medical Sciences
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ScienceOnline.org/librarian
and
Kiki Forsythe
[email protected]
谢谢!
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