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Patricia Beier Fact Sheet on Hallucinogens Moraine Park Technical College Jerry Van Kirk, M.Div., Th.M., ICS Hallucinogenic substances are characterized by their ability to cause changes in a person's perception of reality. Persons using hallucinogenic drugs often report seeing images, hearing sounds, and feeling sensations that seem real, but do not exist. In the past, plants and fungi that contained hallucinogenic substances were abused. Currently, these hallucinogenic substances are produced synthetically to provide a higher potency. LSD: (lysergic acid diethylamide) is one of the major drugs making up the hallucinogen class of drugs. It was discovered in 1938 and is manufactured from lysergic acid, which is found in ergot, a fungus that grows on rye and other grains. LSD binds to and activates a specific receptor for the neurotransmitter, serotonin. Normally, serotonin binds to and activates its receptors and then is taken back up into the neuron that released it. In contrast, LSD binds very tightly to the serotonin receptor, causing a greater than normal activation of the receptor. Because serotonin has a role in many of the brain’s functions, activation of its receptors by LSD produces widespread effects, including rapid emotional swings, and altered perceptions, and if taken in a large enough dose, delusions and visual hallucinations. PCP: (phencyclidine) was developed in the 1950s as an intravenous anesthetic, but its use in humans was discontinued in 1965, because patients often became agitated, delusional, and irrational while recovering from its anesthetic effects. PCP is now being illegally manufactured in laboratories. It is a white crystalline powder that is readily soluble in water or alcohol. It has a distinctive bitter chemical taste. PCP can be mixed easily with dyes and turns up on the illicit drug market in a variety of tablets, capsules, and colored powders. It can be snorted, smoked, or ingested. For smoking, PCP is often applied to a leafy material such as mint, parsley, oregano, or marijuana. PCP, which is not a true hallucinogen, can affect many neurotransmitter systems. It interferes with the functioning of the neurotransmitter, glutamate, which is found in neurons throughout the brain. Like many other drugs, it also causes dopamine to be released from neurons into the synapse. At low to moderate doses, PCP causes altered perception of body image, but rarely produces visual hallucinations. PCP can also cause effects that mimic the primary symptoms of schizophrenia, such as delusions and mental turmoil. People who use PCP for long periods of time have memory loss and speech difficulties. Peyote: is a small, spineless cactus, Lophophora williamsii, whose principal active ingredient is the hallucinogen mescaline (3, 4, 5-trimethoxyphenethylamine). From earliest recorded time, peyote has been used by natives in northern Mexico and the southwestern United States as a part of their religious rites. The top of the cactus above ground--also referred to as the crown--consists of discshaped buttons that are cut from the roots and dried. These buttons are generally chewed or soaked in water to produce an intoxicating liquid. The hallucinogenic dose of mescaline is about 0.3 to 0.5 grams and lasts about 12 hours. While peyote produced rich visual hallucinations that were important to the native peyote cults, the full spectrum of effects served as a chemically induced model of mental illness. Mescaline can be extracted from peyote or produced synthetically. Both peyote and mescaline are listed in the CSA as Schedule I hallucinogens. Psilocybin: is obtained from certain mushrooms found in South America, Mexico, and the U.S, although the substance can also be produced synthetically. Mushrooms containing psilocybin are available fresh or dried with long, narrow stems topped by caps with dark gills on the underside. These mushrooms are usually ingested orally, but can also be brewed in a tea or added to food to mask the bitter flavor. Once ingested, psilocybin is broken down in the user's body to produce psilocyn, another hallucinogenic substance. Mescaline is the active hallucinogenic ingredient in peyote. Peyote is a small, spineless cactus historically used by natives in Mexico and the southwestern U.S. as part of religious rites. Mescaline can also be produced synthetically. DMT: is found in a number of plants and seeds, but can also be produced synthetically. DMT is usually ingested by snorting, smoking, or injecting the drug. DMT is not effective in producing hallucinogenic effects when ingested by itself and is therefore used in conjunction with another drug that inhibits its metabolism. Foxy: also know as Foxy Methoxy, is available in powder, capsule, and tablet form and is usually ingested orally (although it can be snorted or smoked). Foxy capsules and tablets vary in color and logos sometimes appear on tablets. AMT is often found in tablet and capsule form. Dextromethorphan: (sometimes called "DXM" or "robo") is a cough-suppressing ingredient in a variety of over-the-counter cold and cough medications. At the doses recommended for treating coughs, the drug is safe and effective. At much higher doses, dextromethorphan produces dissociative effects similar to those of PCP and ketamine. LSD is synthetically made. Psilocybin is found naturally in several types of magic mushrooms. Other trees, seeds and fungi also have hallucinogenic potential. PCP (Phencyclidine) is an anaesthetic now only used on animals Ketamine is an anaesthetic used on both humans and animals Mescaline can be naturally extracted from peyote cactus, or manufactured synthetically Ecstasy\MDMA and Cannabis can also be a hallucinogen in high doses What does it look like? LSD: Most common form is squares of gelatine or blotting paper. It can also be liquid form, tablets, capsules or white powder (at its most pure) Psilocybin: Appear like dried mushrooms or even powdered into capsules. Synthetically made Psilocybin is a white crystalline powder placed inside capsules, tablets or dissolved in liquid PCP (Phencyclidine) White powder (at its most pure) but generally coloured powder, capsules or pills Ketamine: A white crystalline powder, placed in pills, tablets or dissolved in liquid Mescaline: White crystalline powder (at its most pure). Synthetically made as various colours of powder and capsules Street Names LSD is known as acid, trips, microdots, dots, blotters, mellow or tabs may be named according to the design on the blotting paper e.g. a picture of a yellow star would attract the name, “yellow stars” Mushrooms can be called their common botanical names, magic mushrooms, shrooms, magics, blue meanies, liberty caps, golden tops, mushies PCP: angel dust, peace pill Ketamine: Special K, K, ket, kitkat, super K How They Are Taken? LSD: Swallowed, sniffed, injected or smoked. As a liquid it can be rubbed onto the skin. Psilocybin: Mushrooms can be eaten as they are, used in food recipes, or brewed in tea PCP: Swallowed, snorted, injected or smoked Ketamine: Swallowed, snorted, injected or smoked Mescaline: Usually swallowed. Also chewed or smoked How They Work Hallucinogens affect the central nervous system to drastically alter a user’s sensory perception Why Is It Taken? (Desired Side Effects) • Drastic change in sensory perception • Distorted sense of visuals, auditory, body, time and space • Altered perception of oneself • Hallucinations • Relaxation • Happiness and Satisfaction • Euphoria Unwanted Side Effects Increased rapid heart beat Higher blood pressure Agitation Increased body temperature and sweating may lead to chills Bad hallucinations Panic attacks Anxiety Paranoia Flashbacks after use Dizziness Impaired coordination Nausea and vomiting Bad Trips The negative unwanted side effects of hallucinogens can result in what are commonly known as “bad trips” Many or all of the unwanted side effects can overwhelm a user all at once causing them to experience severe panic and bad hallucinations This can all lead to dangerous and risky behavior The effects generally wear off when the drug wears off but in some cases it can continue for some time afterwards Long Term Side Effects Flashbacks Are the most common long term effects associated with hallucinogens Are moments where the effects of the drug are experienced and this can occur years after use They can last for a few minutes and can either be pleasant or uneasy They are usually visual perhaps involving colors and hallucinations Long term use of hallucinogens could impair memory and other brain functions Personality and mood changes in people have occurred Drug-induced psychosis involving hallucinations and delusional behavior can occur, lasting up to several hours. Withdrawal Effects of withdrawal from hallucinogens have not been clearly established because these drugs do not seem to be physically addictive. They may, however, be psychologically addictive because users feel emotionally dependent on taking them. Overdose and Death Taking large doses of hallucinogens may result in more intense unwanted side effects LSD, Mescaline and Magic Mushrooms have not been directly responsible for deaths. The rare fatalities that have involved the drugs have been a result of accidents, behavior or plant poisoning. Taking extremely large doses of PCP and Ketamine can result in coma, seizures, respiratory arrest and ultimately, death PREGNANCY The use of hallucinogens seems to be linked to an increased risk of miscarriage. There may also be a higher incidence of birth defects among babies born to women using hallucinogens. Addiction and Dependency There have been no reported cases of physical dependency or withdrawal symptoms from hallucinogens. It is however possible to become psychologically dependent, using hallucinogens to function optimally, perhaps in social situations. Frequent use of hallucinogens is not so common, users generally taking the drugs sporadically with generous time periods between. This is because the experience can be extremely intense with a long recovery period. Reference http://www.whitehousedrugpolicy.gov/DrugFact/hallucinogens/hallucinogens_ff.html http://www.ceida.net.au/hallucinogens/ http://www.drugfreeatlast.com/hallucinogens.html http://www.ctclearinghouse.org/topics/customer-files/hallucinogens-the-brains-responseto-drugs.pdf http://www.egetgoing.com/drug_rehab/hallucinogens.asp http://www.justice.gov/dea/concern/peyote.html