* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download The Biology of Extracellular Molecular Chaperones. Novartis Foundation
Survey
Document related concepts
Protein purification wikipedia , lookup
Organ-on-a-chip wikipedia , lookup
Biochemistry wikipedia , lookup
Cell theory wikipedia , lookup
Biochemical cascade wikipedia , lookup
Polyclonal B cell response wikipedia , lookup
Protein adsorption wikipedia , lookup
Two-hybrid screening wikipedia , lookup
State switching wikipedia , lookup
Chemical biology wikipedia , lookup
Western blot wikipedia , lookup
Developmental biology wikipedia , lookup
Neurodegeneration wikipedia , lookup
Protein–protein interaction wikipedia , lookup
Signal transduction wikipedia , lookup
History of biology wikipedia , lookup
Transcript
Brochure More information from http://www.researchandmarkets.com/reports/2171128/ The Biology of Extracellular Molecular Chaperones. Novartis Foundation Symposium, No. 291. Novartis Foundation Symposia Description: Novartis Foundation Symposium 291 The Biology of Extracellular Molecular Chaperones Chair: Péter Csermely The heat shock, or cell stress, response was first identified in the polytene chromosomes of Drosophila. This was later related to the appearance of novel proteins within stressed cells, and the key signal stimulating this appearance was identified as the presence of unfolded proteins within the cell. It is now known that this is a key mechanism enabling cells to survive a multitude of physical, chemical and biological stresses. Since the promulgation of the molecular chaperone concept as a general cellular function to control the process of correct protein folding, a large number of molecular chaperones and protein folding catalysts have been identified, and it has been recognized that not all molecular chaperones are stress proteins and vice versa. The discovery of molecular chaperones as folding proteins went hand–in–hand with their recognition as potent immunogens in microbial infection. It was subsequently shown that administration of molecular chaperones such as Hsp60, Hsp70 or Hsp90 could inhibit experimental autoimmune diseases and cancer. More recently evidence has accumulated to show that certain molecular chaperones are also present on the surface of cells or in extracellular fluids. A new paradigm is emerging: at least some molecular chaperones are secreted proteins with pro– or anti–inflammatory actions, regulating the immune response in human diseases such as coronary heart disease, diabetes and rheumatoid arthritis. In addition to having direct effects on cells, molecular chaperones can bind peptides and present them to T cells to modulate immune responses. This may be significant in the treatment of cancer. This book brings researchers together to review and discuss: - our current knowledge of cell stress response and molecular chaperones - the changing paradigms of protein trafficking and function - cell stress proteins as immunomodulators and pro– and anti–inflammatory signalling molecules - the role of these proteins in various chronic diseases and their potential as preventative or therapeutic agents. The Biology of Extracellular Molecular Chaperones will be of particular interest to immunologists, cell and molecular biologists, microbiologists and virologists, as well as clinical researchers working in cardiology, diabetes, rheumatoid arthritis and other inflammatory diseases. Contents: Symposium on The biology of extracellular molecular chaperones, held at the Novartis Foundation, London, 5 7 June 2007. Editors: Derek J. Chadwick (Organizer) and Jamie Goode. This symposium is based on a proposal made by Brian Henderson, R. John Ellis and A. Graham Pockley Péter Csermely Chair's introduction. Jodie Haak and Kevin C. Kregel 1962 2007: a cell stress odyssey. Discussion. Peter A. Lund and R. John Ellis The chaperone function: meanings and myths. Discussion. Péter Csermely, Tamás Korcsmáros, István A. Kovács, Máté S. Szalay and Csaba Soti Systems biology of molecular chaperone networks. Discussion. Radhey S. Gupta , Nallur B. Ramachandra, Timothy Bowes and Bhag Singh Unusual cellular disposition of the mitochondrial molecular chaperones Hsp60, Hsp70 and Hsp10. Discussion. Martha Triantafilou, Daniel Sawyer, Abdiaziz Nor, Emmanouil Vakakis and Kathy Triantafilou Cell surface molecular chaperones as endogenous modulators of the innate immune response. Discussion. A. Graham Pockley and Gabriele Multhoff Cell stress proteins in extracellular fluids: friend or foe? Discussion. Francisco J. Quintana and Irun R. Cohen HSP60 speaks to the immune system in many voices. Discussion. Stuart K. Calderwood, Jianlin Gong, Jimmy R. Theriault, Salamatu S. Mambula and Philip J. Gray Jnr Cell stress proteins: novel immunotherapeutics. Discussion. General discussion. Brian Henderson Cell stress proteins as modulators of bacteria host interactions. Discussion. Anthony R. M. Coates, Ana Cehovin and Yanmin Hu Chaperonin 60 and macrophage activation. Discussion. Alexzander Asea Hsp70: a chaperokine. Discussion. Hajime Nakamura Extracellular functions of thioredoxin. Discussion. Carol L. Miller–Graziano, Asit De, Krzysztof Laudanski, Tara Herrmann and Sanjukta Bandyopadhyay HSP27: an anti–inflammatory and immunomodulatory stress protein acting to dampen immune function. Discussion. Gabriel S. Panayi and Valerie M. Corrigall BiP, an anti–inflammatory ER protein, is a potential new therapy for the treatment of rheumatoid arthritis. Discussion. Final discussion. Index of contributors. Subject index. Ordering: Order Online - http://www.researchandmarkets.com/reports/2171128/ Order by Fax - using the form below Order by Post - print the order form below and send to Research and Markets, Guinness Centre, Taylors Lane, Dublin 8, Ireland. Page 1 of 2 Fax Order Form To place an order via fax simply print this form, fill in the information below and fax the completed form to 646-607-1907 (from USA) or +353-1-481-1716 (from Rest of World). If you have any questions please visit http://www.researchandmarkets.com/contact/ Order Information Please verify that the product information is correct. Product Name: The Biology of Extracellular Molecular Chaperones. Novartis Foundation Symposium, No. 291. Novartis Foundation Symposia Web Address: http://www.researchandmarkets.com/reports/2171128/ Office Code: SCHL3FA7 Product Format Please select the product format and quantity you require: Quantity Hard Copy (Hard Back): USD 190 + USD 29 Shipping/Handling * Shipping/Handling is only charged once per order. Contact Information Please enter all the information below in BLOCK CAPITALS Title: First Name: Mr Mrs Dr Miss Last Name: Email Address: * Job Title: Organisation: Address: City: Postal / Zip Code: Country: Phone Number: Fax Number: * Please refrain from using free email accounts when ordering (e.g. Yahoo, Hotmail, AOL) Ms Prof Page 2 of 2 Payment Information Please indicate the payment method you would like to use by selecting the appropriate box. Pay by credit card: You will receive an email with a link to a secure webpage to enter your credit card details. Pay by check: Please post the check, accompanied by this form, to: Research and Markets, Guinness Center, Taylors Lane, Dublin 8, Ireland. Pay by wire transfer: Please transfer funds to: Account number 833 130 83 Sort code 98-53-30 Swift code ULSBIE2D IBAN number IE78ULSB98533083313083 Bank Address Ulster Bank, 27-35 Main Street, Blackrock, Co. Dublin, Ireland. If you have a Marketing Code please enter it below: Marketing Code: Please note that by ordering from Research and Markets you are agreeing to our Terms and Conditions at http://www.researchandmarkets.com/info/terms.asp Please fax this form to: (646) 607-1907 or (646) 964-6609 - From USA +353-1-481-1716 or +353-1-653-1571 - From Rest of World