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Atlas of Genetics and Cytogenetics in Oncology and Haematology OPEN ACCESS JOURNAL AT INIST-CNRS Gene Section Short Communication FAD (Fanconi anaemia group D) Jean-Loup Huret Genetics, Dept Medical Information, University of Poitiers, CHU Poitiers Hospital, F-86021 Poitiers, France Published in Atlas Database: April 1998 Online updated version: http://AtlasGeneticsOncology.org/Genes/FAD.html DOI: 10.4267/2042/37433 This work is licensed under a Creative Commons Attribution-Non-commercial-No Derivative Works 2.0 France Licence. © 1998 Atlas of Genetics and Cytogenetics in Oncology and Haematology Prognosis Poor; mean survival is 16 years: patients die of bone marrow failure (infections, haemorrhages), leukaemia, or androgen therapy related liver tumours. Cytogenetics Spontaneous chromatid/chromosome breaks; increased rate of breaks compared to control, when induced by breaking agent. Identity Other names: FACD (Fanconi complementation group D) Location: 3p24.2 Local order: not far to XPC, in 3p25. anaemia References Whitney M, Thayer M, Reifsteck C, Olson S, Smith L, Jakobs PM, Leach R, Naylor S, Joenje H, Grompe M. Microcell mediated chromosome transfer maps the Fanconi anaemia group D gene to chromosome 3p. Nat Genet 1995;11(3):341-3. Probe(s) - Courtesy Mariano Rocchi, Resources for Molecular Cytogenetics. DNA/RNA Description D'Andrea AD, Grompe M. Molecular biology of Fanconi anemia: implications for diagnosis and therapy. Blood 1997;90(5):1725-36. Yet unknown; only localized. This article should be referenced as such: Implicated in Huret JL. FAD (Fanconi anaemia group D). Atlas Genet Cytogenet Oncol Haematol.1998;2(3):83. Fanconi anaemia; FA1 is implicated in the FA complementation group D Disease Fanconi anaemia is a chromosome instability syndrome/cancer prone disease (at risk of leukaemia). Atlas Genet Cytogenet Oncol Haematol. 1998;2(3) 83