Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Innate immune system wikipedia , lookup
Complement system wikipedia , lookup
Psychoneuroimmunology wikipedia , lookup
Cancer immunotherapy wikipedia , lookup
Adaptive immune system wikipedia , lookup
Molecular mimicry wikipedia , lookup
Adoptive cell transfer wikipedia , lookup
Biochemical cascade wikipedia , lookup
Cell-mediated immune response Activation of T lymphocytes by intracellular microorganisms Phases of T cell response Biochemical pathways of T cell activation Functional responses of T lymphocytes to antigens and costimulation Molecules involved in T cell activation TCR TCR complex Costimulators Requirement for two signals in T cell activation Molecules involved in T cell activation Coreceptor Adhesion molecule Molecules involved in T cell activation Accessory molecules Molecules involved in T cell activation Immunological synapse Biochemical pathways of T cell activation Clustering of two or more TCRs Functional responses of T lymphocytes to antigens and costimulation Clonal expansion of T-limphocytes Diferentiation od CD4+ T-limphocytes IFN-g IL-12+IL-18 IL-4 Th1 Th2 Naivna Naïve CD4++T TGF-b+IL-6 IL-23… TGF-b Th17 Treg Diferentiation od CD4+ T-limphocytes IFN-g IL-12+IL-18 IL-4 Th1 T-bet Th2 GATA-3 Naivna Naïve CD4++T TGF-b+IL-6 IL-23… TGF-b Th17 RORgt Treg FoxP3 Diferentiation of naive CD4+ T-cells Diferentiation od CD8+ T-limphocytes 1. Recognition of antigen by T cells is mediated by a. IL-2 2. Signal transduction in T cells is mediated by b. stabilize binding of T-cells to APC c. a and b chains of TCR 3. Accesory molecules involved in T cell activation are d. two signals 4. Costimulatory signals for T cell activation are provided by e. NFAT, NF-kB and AP1 5. T cell growth factor is f. CD28 and B7 molecules 6. If APC does not express costimulatory molecules 7. Adhesion molecules g. CD3, CD4, CD8, CD28 and adhesion molecules 8. Activation of naive T-cells requires h. IL-12 9. Cytokine that is crucial for TH1 differentiation is i. T cell is not activated 10. Main transcription factors in T cell activation are j. CD3 complex and z chains 1.____ c 2.____ j 3.____ g 4.____ f 5.____ a 6.____ i 7.____ b 8.____ d 9.____ h 10.____ e