Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download Behavioral Neuroscience
Document related concepts
Artificial gene synthesis wikipedia , lookup
Gene expression programming wikipedia , lookup
Heritability of IQ wikipedia , lookup
Genetic engineering wikipedia , lookup
History of genetic engineering wikipedia , lookup
Genome (book) wikipedia , lookup
Microevolution wikipedia , lookup
Designer baby wikipedia , lookup
Epigenetics of depression wikipedia , lookup
Transcript
The Sackler Institute For Developmental Psychobiology Columbia University NY State Psychiatric Institute Established April, 2001 Sackler Institute at Columbia DIVISIONS Clinical Behavioral Neuroscience Basic Science Research on Developmental Processes Department of Psychiatry School of Public Health Pediatrics/Neonatology Obstetrics and Gynecology Biochemistry and Molecular Biophysics Psychoanalytic Center Parent/Infant Program Behavioral Medicine Neurobiology and Behavior Sackler Institute at Columbia DIVISIONS Clinical Myrna Weissman Behavioral Neuroscience Myron A Hofer, Director Jennifer Knowles, Administrator Basic Science Thomas Jessell William Fifer, Assistant Director Michael Myers Jonathan Polan Jay Gingrich Developmental Neuroimaging Bradley Peterson Sackler Award and NIMH Research Fellowships Clinical Division Myrna Weissman, PhD Genetic Epidemiology • What are the risk factors for mood and anxiety disorders across generations? • 3 Generations of Depression: – Anxiety in childhood – Depression in adolescence and adulthood • Current study on serotonin transporter gene – Genetic variants, EEG responses and MRI Behavioral Neuroscience Myron Hofer, MD, Director Developmental Role of Parent/Infant Interactions • Formation of attachment • Mechanisms of separation effects • Regulation of development Early Development of Social Cognition in Transgenic Models of Autism Behavioral Neuroscience Michael Myers, PhD Long-term Effects of Early Experience • Infant feeding experiences: role in shaping autonomic nervous system development • Intrauterine and neonatal nutrition: programming of metabolic and neurobehavioral disorders • Epigenetic mechanisms and underlying effects Behavioral Neuroscience Jonathan Polan, MD Maternal-Infant Neurobiology Transgenic model: Dopamine type 2 receptor gene • Reversibly increased levels in striatum – Limited to prenatal period • Specific defect in working memory • Models cognitive deficit in schizophrenia Basic Science Thomas Jessell, PhD Developmental Neurobiology: Genes, Molecules and Cells • How do neurons first establish their identity? • What cues guide them to their targets? • How do neuronal circuits forms and function? Sackler Institute at Columbia DIVISIONS Clinical Myrna Weissman Behavioral Neuroscience Myron A Hofer, Director Jennifer Knowles, Administrator Basic Science Thomas Jessell William Fifer, Assistant Director Michael Myers Jonathan Polan Jay Gingrich Developmental Neuroimaging Bradley Peterson Sackler Award and NIMH Research Fellowships Behavioral Neuroscience William Fifer, PhD, Assistant Director Fetal/Infant Neurobehavioral Development • Exposure to nicotine, alcohol and SSRI’s – Link to SIDS • Effects of Maternal Anxiety and Depression on fetal behavior and autonomic system Behavioral Neuroscience Myron Hofer, MD, Director Developmental Role of Parent/Infant Interactions • Formation of attachment • Mechanisms of separation effects • Regulation of development Early Development of Social Cognition in Transgenic Models of Autism Behavioral Neuroscience Myron Hofer, MD, Director Developmental Role of Parent/Infant Interactions • Formation of attachment • Mechanisms of separation effects • Regulation of development The Evolution of Development Developmental Neuroimaging Bradley Peterson, MD Long-term effects of premature birth 3 generations at risk for depression • Virtual reality paradigms • Diffusion tensor imaging Behavioral Neuroscience Jay Gingrich MD, PhD Transgenic Models of Schizophrenia and Depression • Neuroligin genes and cognitive deficits of schizophrenia • Serotonin 2A receptors necessary for responses to hallucinogenic drugs • Serotonin transporter gene knockout reveals unique early developmental role for serotonin in depression Myrna Weissman Bradley Peterson 3 generation study – Genetic Varients – EEG started – MRI William Fifer Catherine Monk Novel Role for Serotonin in Early Development • Transporter gene under-expression increases vulnerability – Clinical: short form of gene linked to adult depression – Knockout mice show adult depressive phenotype • SSRI: paradoxical effects – Pregnant women: neonatal syndrome – Children and Adolescents: ineffective and/or activating – Pre-weaning mice show adult “depressive” phenotype
