Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Download lin-14(sd)
Document related concepts
Transposable element wikipedia , lookup
Polycomb Group Proteins and Cancer wikipedia , lookup
Epigenetics of human development wikipedia , lookup
Epigenetics in stem-cell differentiation wikipedia , lookup
Therapeutic gene modulation wikipedia , lookup
Gene therapy of the human retina wikipedia , lookup
Site-specific recombinase technology wikipedia , lookup
Designer baby wikipedia , lookup
Vectors in gene therapy wikipedia , lookup
History of genetic engineering wikipedia , lookup
RNA silencing wikipedia , lookup
Transcript
Scanning em of C. elegans Crawl movie Fly-in movie Male, scanning em Male tail scanning em Rene Mating Movie Embryonic cell lineage D lineage ABala lineage AIML lineage AIML neuron AIML circuit Postembryonic blast cells Z1Z2 Z3 Z4 Adult hermaphrodite anatomy C. elegans typical cross section Seam cell postembryonic lineages in the male wild type lin-4(e912) reiterations wild type lin-14(sd) repeats S1 lin-14(lf) skips S1 lin-4(e912) lin-14(sd) lin-4(lf) and lin-14(gf) have the same phenotype: they repeat S1. LIN-4S is complementary to sequences in the 3’UTR of lin14. Human miRNA genes Symmetric neuron phenotype of lsy-6(-) A regulatory pathway leading to neuron asymmetry involving two micro RNA’s Worms Eating Bacteria Expressing dsRNA to a GFP Reporter Gene Activate RNAi wild type worms RNAi-defective mutants from Mello and Conte, Nature 431, 338-342. GFP lost in embryos GFP lost in the gut RNAi in Plants 1928 report of development of viral (tobacco ringspot virus) resistance in tobacco, now known to be due to endogenous RNAi. RNAi/miRNA Pathways from Meister and Tuschl, Nature 431, 343-349, 2004. The Structure of Argonaute (Slicer) Song et al., Science 305, 1434-1437, 2004.
