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Other Diseases & Disabilities Hereditary Diseases ~ Diseases caused by abnormal chromosomes or by defective genes inherited from one or both parents. Genes • ~ Segments of DNA located on a chromosomes that code for a specific hereditary trait Single-gene Diseases ~ Occur when 1 gene out of 30,000 to 40,000 genes in the body has a harmful mutation. Mutation ~ When a gene carries incorrect instructions Huntington’s disease ~ degeneration of brain cells Sickle cell anemia ~ blood disease in which the body produces defective hemoglobin. Hemophilia ~ blood disease in which the body produces little or none of the blood proteins necessary for clotting. Cystic fibrosis ~ disease of the body’s mucous glands. It primarily affects the respiratory and digestive systems of children and young adults. Complex Diseases ~ More than one gene influences the onset of a disease. Lifestyle behaviors can contribute to a person’s chance of developing a complex disease ~ CVD’s such as stroke, high blood pressure, heart attacks, arteriosclerosis, type 2 diabetes and cancer are examples of complex diseases. Chromosomal Diseases ~ When a person inherits the wrong number of chromosomes or an incomplete chromosome. ~ Humans normally have 23 chromosomes in each cell. ~ Most common Chromosomal Disease in the U.S. is Down Syndrome. Immune Disorders ~ If the immune system does not function properly it can result in an immune disorder. ~ Examples of immune disorders are allergies, asthma and AIDS. Autoimmune Diseases ~ When the immune system attacks the cells of the body that the immune system normally protect. ~ Rheumatoid arthritis is an autoimmune diseases are in which the immune system attacks the joints. ~ Multiple Sclerosis occurs when the immune system attacks the fatty insulation of nerves in the brain and spinal cord.