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What’s so important about getting the right colostrum? All newborn farm animals are born with minimal immunity against infections. They gain immunity by feeding on their mother’s colostrum, but even then full immunity does not develop for 3 – 4 months. Unfortunately the quality and quantity of mother’s colostrum is often poor and mothers will only produce anti-bodies against diseases to which they have been exposed or immunized against. Net-Tex concentrated colostrum powders and pastes are designed to provide everything the mother failed to do. Net-Tex’s concentrated first day colostrums contain naturally high levels of; Immunoglobulins: - Antibodies IgG Neutralizes toxins and other invaders; including viruses and bacteria IgM Destroys bacteria, controls antibody response IgD Antiviral, prevents hemolytic disease in infants IgE Involved in regulating allergic response IgA Highly antiviral and antibacterial, prevents infection Other compounds Secretory IgA IgA Helper Lactoferrin Lactoferrin-Fe Transferrin Glycoproteins: Lactalbumin Cytokines Lysozymes Gamma Globulin B Lactoglobulin C3 & C4 Kappa Casein Alpha 2-AP Alpha 1 Orosomucoids Prealbumin Albumin Oligosaccharides (SigA) Found in mucous membranes, helps protect against infection Stimulates the production of IgA Powerful antioxidant, antiviral, antibacterial, anti-inflammatory Iron chelator Binds and transports iron Including Protease and Trypsin Inhibitors. Protect components from destruction by stomach acids Raises brain serotonin levels, improves mood under stress Including Interleukins, Interferon Y, Tumor Necrosis Factor (TNF), and Lymphokines. Antiviral, anti-tumor (stimulates death of some tumors), increase T- cell activity, responsible for regulation and intensity of immune response, stimulate production of immunoglobulins Help protect body from bacterial infection, topical antibiotic Resists infection Antibody, protein Proteins that activate the immune system Glycoprotein that protects against the bacteria that causes stomach ulcers Glycoprotein Antitrypsin – Inhibitor of trypsin Alpha 2- macroglobulin – Function as hormonal transporters Alpha-1 protein in plasma Precursor to albumin Contains essential amino acids Complex carbohydrates, help prevent lung inflammations and ear infection Non Specific Inhibitors (NSI’s) Proline-Rich Polypeptide (PRP) Factors that inhibit a wide range of respiratory illness Regulates the activity of the immune system To which Net-Tex adds: IgY From Hyperimmune egg proteins (see overleaf) Pre-biotics Pro-biotics Vitamins & Minerals Plus a Potent Energy Source All Net-Tex natural colostrums and additives are blended using Collate technology to yield a most rapid and complete uptake of the active ingredients. Problems with Rotavirus, Coronavirus, E. Coli, Salmonella & Cryptosporidium? Net-Tex provides another Scientific Breakthrough in Newborn Technology ! ROTO~CORONA PLUS – For newborn and transported calves Rotavirus and Coronavirus are highly contagious viruses and, along with E.Coli and Salmonella bacteria and Cryptosporidium protozoa, are the most common cause of severe diarrhoea in newborn calves and bought-in calves (calves having been tightly penned together at markets or in trucks). First clinical signs of infection are dull calves reluctant to drink, followed by a sudden onset of a pale yellow diarrhoea, sometimes with mucous and blood present. Severe dehydration soon follows which causes the whole digestive system to shut down. Mortality can occur but slow recovery with long term lack of thrift is more usual. Rotavirus, Coronavirus, E. Coli, Salmonella and Cryptosporidium immunity may be gained through anti-bodies in the mother’s first colostrum if it is taken within the first hours of birth (but only if the mother has been subjected previously to these pressures). Net-Tex provides these anti-bodies in a concentrated form in Roto~Corona Plus paste to supplement what nature failed to do. Anti-bodies from Mammalian and Avian* sources are combined with vitamins A, D & E, pre-biotics and pro-biotics in an oral syringe. Corn Oil and Coconut Oil are added to provide instant energy, to stimulate the gut and to aid digestibility. Using Collate technology these ingredients are rapidly absorbed into the bloodstream to enable a fast response and to help develop the immune system. *Why add Chicken Antibodies and IgY? Chickens produce a unique class of immunoglobulin molecules called IgY’s that can be harvested from the egg yolk. Chicken IgY is the functional equivalent to mammalian IgG (see overleaf). It is found in the serum of chickens and is passed from the mother chicken to the embryo via the egg yolk, imparting a high concentration of chicken IgY to the developing embryo. Hyperimmune eggs Hens elicit a strong antibody response if they are exposed to pathogenic protein sequences such as bacteria and viruses. Researchers found that hens (after they had been stimulated multiple times with whole or parts of inactivated disease microorganisms or purified antigens) would lay eggs containing high levels of specific disease antigens. Eggs prepared this way are known as “hyperimmune eggs”. Such eggs are harvested and the yolks collected and purified to produce titres of immunoglobulin anti-bodies (described as specific egg proteins). Immunoglobulins from chickens bear considerable resemblance to mammalian IgG’s, but also display some unique structural and functional characteristics that distinguish them from IgG. There are many advantages to using IgY antibodies: • • • • Specific titres of anti-body can be produced for Rotavirus, Coronavirus, E. Coli, and Salmonella Along with the production of antibodies, stimulation of the hens results in generation of small molecules having anti-inflammatory properties. These factors appear to help the body initiate defenses against pathogens such as the Cryptosporidium protozoa, and help maintain immune system control. Hyperimmune egg appears to “balance” immunologic responses, rather than “boost” or unnecessarily “enhance” these processes. Upon ingestion, much of the IgY immunoglobulin is apparently still able to bind antigen despite exposure to digestive enzymes. Important when feeding older calves. Net-Tex uses hyperimmune egg proteins as its IgY source. Net-Tex blends all its Collate colostrum powders and paste at its dedicated factory in Kent, England.