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Download A typical hemoglobin molecule consists of a "heme" part and a
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Transcript
A typical hemoglobin molecule consists of a "heme" part and a protein part=globin. The "heme" part lies in the interior of the hemoglobin molecule. At the center of the heme is an Fe(II), ferrous, atom. Four of the six coordination sites around this atom are occupied by nitrogen atoms from a porphyrin ring. The fifth coordination site is occupied by a nitrogen atom from a histidine side chain on one of the amino acids in the globin. The last coordination site is available to bind an O2 molecule. The heme is therefore the oxygen-carrying portion of the hemoglobin molecules. This raises the question: What is the function of the globular protein or "globin" portion of these molecules? The oxygen-carrying heme group is buried inside the protein portion of the hemoglobin molecule, which keeps "heme" groups from coming too close together. This is important, because these molecules need to bind O2 reversibly and the Fe(II) heme, by itself, cannot do this. When there is no globin to protect the heme, it reacts with oxygen to form an oxidized Fe(III),ferric, atom instead of an Fe(II)-O2 complex. Hemoglobin consists of four protein chains. Hemoglobin has four separate heme groups that can bind a molecule of O2. Yellow= alpha chains Blue= beta chains Red= iron atoms