Download Intravenous Immunoglobulin in Autoimmune Neuromuscular

From: Intravenous Immunoglobulin in Autoimmune Neuromuscular Diseases
JAMA. 2004;291(19):2367-2375. doi:10.1001/jama.291.19.2367
Figure Legend:
Intravenous immunoglobulin (IVIG) modulates multiple immunologicevents (blue boxes) involved in the pathogenesis of autoimmune
neuromusculardiseases. Diseases for which specific therapeutic actions of IVIG are supportedby experimental evidence are listed in
each box. In autoimmune neuromusculardiseases, an antigen, through molecular mimicry, defective clonal deletion,or other
mechanisms, triggers an immune response that results in loss of immunetolerance to self-antigens. Infused IVIG interferes with
costimulatory moleculesinvolved in antigen presentation
modulates
subsequent
immunologic events.These events, mediated by
Copyrightand
© 2004
American
Medical
Date
of download:
5/14/2017
activation
of B cells
with production of autoantibodiesand
by
T
cells,
lead
to
tissue
damage
via complement activation, macrophage–
Association. All rights reserved.
Fcreceptor interaction, and cytotoxic T cells. Other possible therapeutic actionsof IVIG not shown in this illustration include
From: Intravenous Immunoglobulin in Autoimmune Neuromuscular Diseases
JAMA. 2004;291(19):2367-2375. doi:10.1001/jama.291.19.2367
Figure Legend:
Muscle biopsy specimens from a patient with dermatomyositis who hadsubstantial clinical improvement after 3 infusions of
intravenous immunoglobulin(IVIG) were stained with monoclonal antibodies to intercellular adhesion molecule1 (ICAM-1) using an
immunoperoxidase technique. A, Before IVIG therapy, ICAM-1is strongly expressed on endothelial cells, infiltrating lymphocytes,
andoccasional muscle fibers (brown chromogen). B, After therapy, ICAM-1 expressionis markedly suppressed, and the size of the
muscle fibers is increased. Nucleiappear blue inCopyright
both panels.
(Counterstain:
hematoxylin; original magnification×125). Photo
© 2004
American Medical
Date
of download:
5/14/2017 Health.
source:
National Institutesof
Association. All rights reserved.