Download CURRICULUM VITAE - Laboratory for Chemical Biology

Jump to navigation
Zickler Laboratory of
Chemical Biology





o
o







Home
Contact Us
Give
Home
News
Alumni
Evelyn Glick Chair
Lecture Series
Albert Lecture Series
Zickler Lecture Series
Research Support
Research
Scientists
Publications
Pharmacology Sciences
Stony Brook University
Contact Us
Research
Overview
The Laboratory for Chemical Biology (LCB) was founded in 1988, assisted by
a generous gift from Mr. and Mrs. Leo Zickler of Washington, D.C. Currently,
the Laboratory is directed by Arthur P. Grollman M.D., Distinguished Professor
of Pharmacological Sciences, Professor of Medicine and Evelyn Glick
Professor of Experimental Medicine. Edward Reich, M.D. PhD, Distinguished
Professor of Pharmacological Sciences, was founding Director of the LCB.
In the LCB, molecular and cell biologists collaborate with chemists in exploring
relationships between the three-dimensional structures of damaged DNA and
the function of enzymes involved in its repair. Toward that end, mechanisms of
DNA damage recognition, mutational specificity, DNA replication and repair are
studied
at
the
cellular,
molecular
and
atomic
levels.
LCB investigators pioneered the development of site-specific systems used to
explore mechanisms of mutagenesis induced by defined DNA lesions, and to
elucidate enzymatic pathways for the repair of oxidative DNA damage in
mammalian cells. Earlier research from the LCB was instrumental in
establishing mechanisms by which the radiomimetic anti-tumor drug,
bleomycin, generates unique strand breaks in duplex DNA. Additionally,
translational research by LCB investigators linked endometrial cancer with
exposure
to
the
antiestrogen,
tamoxifen.
Recently, LCB scientists brought their interdisciplinary strengths to bear on the
etiology of human cancer. The unsuspected carcinogenicity of certain herbal
remedies was revealed by their seminal studies of Aristolochia toxicity. This
research illustrates the power of combining mechanistic information with
molecular epidemiological approaches in establishing causative linkages
between environmental mutagens and human disease.



A
A
A
Apply to
School of Medicine
Residency &
Fellowship Programs
Basic Sciences
Graduate Programs
Health Sciences
Library
Office of
Student Services
CBase
Media Services
Stony Brook Univ.
Book Store
HIPAA Training
Directory
Give us a call
For General Information
(631) 689-8333
For School of Medicine Admissions (MD Program)
(631) 444-2113
For Undergraduate Medical Education
(631) 444-1030
For Graduate Medical Education
(631) 444-2084
School of Medicine
101 Nicolls Road
Health Sciences Center, Level 4, Rm 147A
Stony Brook, NY 11794-8434
Students
Admissions
Residents & Fellows
Faculty
Office of Academic and Faculty Affairs
Directory
New Innovations
CBASE Faculty
CBASE Student
Stony Brook University
Legal/Disclaimer
Stony Brook Medicine
Privacy Policy
© Copyright 2016 Stony Brook Medicine
Long Island State Veterans Home
Notice of Privacy Practices
Site Feedback