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Introduction to Immunology: AS.020.229.21
Course Dates: June 29, 2015—July 30, 2015
Class Times: M, W, Th 10:00am-11:45am
Class Location: Homewood Campus, Room 101 Macaulay Building
Instructor:
Abby Geis
Medical campus Cancer Research Building 1 Room 424
[email protected]
Prerequisites: Biology. Molecular biology is not required, but it is recommended that you are familiar with
DNA replication and gene transcription.
Following completion of this course, students should be able to:
1. Identify and express the need for an effective immune system.
2. Rationalize the contributions of 1st & 2nd line innate defenses. Predict effects of various deficiencies in
terms of intensity of inflammatory response & overall host immunity to pathogen-mediated damage.
3. Recite 4 steps of monocyte extravasation from blood vessels to sites of infection.
4. Name 3 antigen presenting cells and compare & contrast their roles in immune defense.
5. Describe 3 main features that differ between innate and adaptive immunity.
6. Describe the features that confer antigen specificity to T and B cells of adaptive immune system.
7. Understand how 2 qualities of MHC (poly-genic & -morphic) contribute to diversity of repertoire and
prevent pathogen escape from presentation. Discuss the advantages & potential disadvantages.
8. Explain the 3 signals that lead to T cell activation & consequences of only 1-2 signals.
9. Recall the major effector function of B cells, helper T cells, cytotoxic T lymphocytes, regulatory T cells,
and mast cells. Apply this knowledge to form testable hypotheses for a variety of phenomena.
10. Understand the importance of immune regulation and the consequences of an overwhelming immune
response.
11. Identify & explain plausible causes of particular immune-mediated disease phenotypes.
Required Text: Charles Janeway’s Immunobiology. 8th edition
Syllabus
Date
Topic
Content summary
June 29, 2015
Introduction
July 1, 2015
Innate Immunity
1
Innate Immunity
2
Antigen
Recognition &
Presentation
History & overview of immune
system function, cells, & organs
First Line of Defense
July 2, 2015
July 6, 2015
Second Line of Defense: PAMPs
& PRRs (Danger theory); Quiz 1
Linking innate & adaptive
immunity
July 8, 2015
Adaptive
Immunity 1
V(D)J recombination (intro); T
cell development & functions;
tolerance
July 9, 2015
Adaptive
Immunity 2
B cell development & functions;
Quiz 2
Required Reading (due before
class)
Chapter 1 pgs 1-25 & 29-31
Chapter 2 pgs 37-60, 64-66, & 69
Chapter 3 pgs 75-85, 89-90, 92, 96,
99-110, 113-115, 118-120
Chpt 4 pgs 127-130, 134-136, 138145, 148-153; Chpt 6 pgs 201-217,
221-228; Chpt 9 pgs 342-353; &
Chpt 11 pgs 429-433
(Zinkernagel & Doherty 1974 MHC
restriction Nature article)
Chpt 5 pgs 157-158, 173-176; Chpt
8 pgs 290-294, 305-315; & Chpt 9
pgs 335-337, 353-355, 357-366,
369-370, 372-381
Chpt 5 pgs 176-179, 182, 184-185;
Chpt 8 pgs 275-277, 282-290; &
Chpt 10 pgs 387-392, 395, 398-400,
July 13, 2015
July 15, 2015
July 16, 2015
July 20, 2015
July 22, 2015
July 23, 2015
July 27, 2015
July 29, 2015
July 30, 2015
Rubric
Quizzes
Midterm
Final Exam
Building an
Directional activation,
effective adaptive communication between effector
immune response arms, regulation & establishing
memory
Midterm Review Includes ALL content covered
through July 13
Midterm
Mucosal
MALT & GALT: More
Immunity
prokaryote than eukaryote
(defense for the Danger theory)
Allergy
Distinguishing allergy from
intolerance
Autoimmunity
A break in tolerance
Quiz 3
Cancer
Pro- & Anti-carcinogenic
inflammation
Course Review
Exam will be cumulative
Final Exam
20%
40%
40%
408-410, 412-421
Chpt 11
Attached review article(s)
Chpt 14; Attached Nature review
Chpt 15; Attached JAutoimmunity
review
Chpt 16