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Introduction to Immunology: AS.020.229.21 Course Dates: June 29, 2015—July 30, 2015 Class Times: M, W, Th 10:00am-11:45am Class Location: Homewood Campus, Room 101 Macaulay Building Instructor: Abby Geis Medical campus Cancer Research Building 1 Room 424 [email protected] Prerequisites: Biology. Molecular biology is not required, but it is recommended that you are familiar with DNA replication and gene transcription. Following completion of this course, students should be able to: 1. Identify and express the need for an effective immune system. 2. Rationalize the contributions of 1st & 2nd line innate defenses. Predict effects of various deficiencies in terms of intensity of inflammatory response & overall host immunity to pathogen-mediated damage. 3. Recite 4 steps of monocyte extravasation from blood vessels to sites of infection. 4. Name 3 antigen presenting cells and compare & contrast their roles in immune defense. 5. Describe 3 main features that differ between innate and adaptive immunity. 6. Describe the features that confer antigen specificity to T and B cells of adaptive immune system. 7. Understand how 2 qualities of MHC (poly-genic & -morphic) contribute to diversity of repertoire and prevent pathogen escape from presentation. Discuss the advantages & potential disadvantages. 8. Explain the 3 signals that lead to T cell activation & consequences of only 1-2 signals. 9. Recall the major effector function of B cells, helper T cells, cytotoxic T lymphocytes, regulatory T cells, and mast cells. Apply this knowledge to form testable hypotheses for a variety of phenomena. 10. Understand the importance of immune regulation and the consequences of an overwhelming immune response. 11. Identify & explain plausible causes of particular immune-mediated disease phenotypes. Required Text: Charles Janeway’s Immunobiology. 8th edition Syllabus Date Topic Content summary June 29, 2015 Introduction July 1, 2015 Innate Immunity 1 Innate Immunity 2 Antigen Recognition & Presentation History & overview of immune system function, cells, & organs First Line of Defense July 2, 2015 July 6, 2015 Second Line of Defense: PAMPs & PRRs (Danger theory); Quiz 1 Linking innate & adaptive immunity July 8, 2015 Adaptive Immunity 1 V(D)J recombination (intro); T cell development & functions; tolerance July 9, 2015 Adaptive Immunity 2 B cell development & functions; Quiz 2 Required Reading (due before class) Chapter 1 pgs 1-25 & 29-31 Chapter 2 pgs 37-60, 64-66, & 69 Chapter 3 pgs 75-85, 89-90, 92, 96, 99-110, 113-115, 118-120 Chpt 4 pgs 127-130, 134-136, 138145, 148-153; Chpt 6 pgs 201-217, 221-228; Chpt 9 pgs 342-353; & Chpt 11 pgs 429-433 (Zinkernagel & Doherty 1974 MHC restriction Nature article) Chpt 5 pgs 157-158, 173-176; Chpt 8 pgs 290-294, 305-315; & Chpt 9 pgs 335-337, 353-355, 357-366, 369-370, 372-381 Chpt 5 pgs 176-179, 182, 184-185; Chpt 8 pgs 275-277, 282-290; & Chpt 10 pgs 387-392, 395, 398-400, July 13, 2015 July 15, 2015 July 16, 2015 July 20, 2015 July 22, 2015 July 23, 2015 July 27, 2015 July 29, 2015 July 30, 2015 Rubric Quizzes Midterm Final Exam Building an Directional activation, effective adaptive communication between effector immune response arms, regulation & establishing memory Midterm Review Includes ALL content covered through July 13 Midterm Mucosal MALT & GALT: More Immunity prokaryote than eukaryote (defense for the Danger theory) Allergy Distinguishing allergy from intolerance Autoimmunity A break in tolerance Quiz 3 Cancer Pro- & Anti-carcinogenic inflammation Course Review Exam will be cumulative Final Exam 20% 40% 40% 408-410, 412-421 Chpt 11 Attached review article(s) Chpt 14; Attached Nature review Chpt 15; Attached JAutoimmunity review Chpt 16