Download PTHR18866 CARBOXYLASE:PYRUVATE/ACETYL

PTHR18866
CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA
CARBOXYLASE
(biotin-dependent carboxylases)
PTHR18866 - reaction
PTHR18866 – domains
Only BC is aligned well in the family and some of the BCCP
PTHR18866 – domains
PTHR18866 – alignment & pruning
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PTN001051111
- alignment not good + gene names
PTN001821692
- some BCCP, but aligned to the BC domain
PTN001821812 - 2 proteins
PTN001821906
– decarboxylases, BC doesn’t align well
PTN000429567
PTN000429781 – single protein
PTN001051113
(top node)
(2nd node)
(last node)
PTN001051111
PTN001821692
PTN001821906
PTHR18866 – annotations
• After pruning, the alignment is good
• “Biotin carboxylase activity” can be
propagated to all
• Could also propagate “biotin binding” and
“ATP binding”
PTN000429799 - PCC activity
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PCC activity
mitochondria
amino acid and fatty acid catabolic processes
(pmid:1000000221)
PTN000429426 - PYC
• Pyruvate-CoA carboxylase activity
• there is a difference in localization between
fungi and animals: cytosolic vs mitochondrial
• BP: oxaloacetate metabolic process +
gluconeogenesis
PTN001051134 - UCA
• Allophanate hydrolase activity plus urea
carboxylase activity
• there is http localization to cytosol
• BP: allantoin and urea catabolic process
PTN000429606 - ACC
• Acetyl-CoA carboxylase activity
• all cytoplasmic, except yeast hfa1 and clade
including ACC2 - these are mitochondrial
• propagated “fatty acid biosynthetic process”,
acetyl-CoA metabolic process, malonyl-CoA
biosynthetic process and lipid metabolic
process
PTN000429500 - MCC
• methyl-crotonyl-CoA carboxylase
• mitochondrial localization
• leucine catabolic process