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Highly Specialized
Diagnostic Products
P.O.Box 212671, Elite Business Center, 1st Floor # 109, Al-Barsha, Dubai, UAE
+971 4 3255730
800-ECLABS
[email protected] www.easternbiotech.com
TABLE OF CONTENTS
Page No
About Us 3
Highly Specialized Diagnostic Products - Introduction
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1. Specialized Screening Tests
a. New Born Screening (NBS) b.Insure®FIT™
2. Clinical Genetics
3. Clinical Genomics
4. Cancer Genetics
a.
b.
c.
d.
e.
f.
g.
h.
Non Invasive Prenatal Test (TRIGENE)
Parkinson-Alzheimer-Dementia Panel Diabetes/Obesity Panel Pan Cardio Panel
Retinal Degeneration Panel
Targeted Mutation Screening
Carrier Screening Test
Inherited Disease Panel
a. Whole Exome Sequencing b. Whole Genome Sequencing
a. BRCA1/2 Full Sequencing with deletion & duplication b.BRCAPlus™
c.BreastNext™
d.ColoNext™
e.GynPlus™
f. Comprehensive Cancer Panel
5. Wellness/Anti Aging/Lifestyle Genetic Tests
a. Geneus™ b. Telomere Test c.Karmagenes
d. SkinCareDNA e. Fitness & Diet Genetic Test f. GPL SNP1000
6. Wellness/Anti Aging/Lifestyle Non Genetic Tests
a. Food Intolerance Test (FOODWatch) b. Food Allergy Test
c. Executive Wellness Profile
d. Organic Acid Test
e. Comprehensive Stool Analysis
f. Gluten/Casein Peptides Test
g. Weight Management Profile
h. Skin Vitality Profile
i. Sleep Balance Profile
j. Adrenal Stress Profile
k. Fertility Profile
l. Cardio Metabolic Profile
m. Neurotransmitters n. Urine Hormones Metabolites
o. Metals Hair Test 7. Counseling Services
a. Genetic Counseing b. Nutritional Counseling
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ABOUT US
Eastern Biotech & Life Sciences is a Medical Diagnostic Services company based in Dubai
Science Park. The company has been in operation for over 10 years and has been at the forefront of Diagnostic healthcare in
the region. It was established to bring a paradigm shift in the diagnostic industry in the MENA region through adoption of
innovative technologies and exceptional customer service.
Eastern Biotech and Life Sciences started with a goal of providing predictive and personalized healthcare, the company filled the
niche in the highly specialized diagnostic and emerging genetic testing market. Upon achieving a leading market position and
regional brand recognition, the company incorporated routine diagnostic testing to its portfolio by setting up its own diagnostic
laboratory in Barsha, Dubai and developed a web portal offering all diagnostic tests on B2B and B2C platforms.
The combined Eastern Group of Companies that includes Eastern Biotech and Eastern Clinical Laboratories now offers its services
through various channels which include partner laboratories, clinics, hospitals independent doctors, and a ‘Direct-to-Customer’
web portal. The experience gained so far has also allowed us to enhance our services to include Quality and Accreditation support
and Project Management for the setting up and commissioning of new laboratories.
Our team of highly qualified and hard working professionals anticipates the future with a renewed sense of enthusiasm to go
beyond the ordinary to become an exceptional provider of diagnostic services and to grow beyond the region into the global
market.
MISSION:
To provide a diagnostic service with superlative standards of Efficiency, Ethics and Quality at an affordable cost
VISION:
To be the leading provider of affordable diagnostic services in the region
VALUES:
• An Obsession with Quality
• Ethical in all areas of work
• Outstanding customer service that exceeds expectations
GOALS:
• Regional and International expansion in the field of medical diagnostic services and developing a strong collaborative
partner network to exponentially increase the client base
• To build an unmatched reputation in the healthcare sector
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HIGHLY
SPECIALIZED
PRODUCTS
The definition of a genetic test has changed as the applications have evolved The circumstances of the individual genetic test - including the acute nature of the phenotype, the age of the
patient, family history and specimen availability - guide the selection of tests and test platforms
Our highly specialized test offerings have been carefully hand picked to meet quality, time, technology, & cost
needs of our clients
The portfolio contains clinical testing applications that span medical disciplines, including & not limited to:
Predictive Genetic Tests, Personalized Genetic Tests, Specialized Immunological Tests, Anti Aging & Wellness
Specialty Profiles
Below are some of our featured products in each category
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1.
SPECIALIZED
SCREENING TESTS
Screening tests are laboratory tests that help to identify people with increased risk
for a condition or disease before they have symptoms or even realize they may be at
risk so that preventive measures can be taken. Screening tests help detect disease in
its earliest and most treatable stages. They should be sensitive - that is, to correctly
identify those individuals who have a given disease. Many routine tests performed at
regular health exams are screening tests such as Cholesterol testing and Pap smears
for women. Newborns are screened for a variety of conditions at birth.
• New Born Screening (NBS)
• Insure®FIT™
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New Born Screening (NBS)
Description:
Newborn screening identifies babies with treatable
congenital disorders to prevent adverse outcomes.
All of the disorders on the newborn screening panel
can be detected by a blood spot collected on filter
paper after 24 hours but within 48 hours of birth.
Application(s):
•Early diagnosis helps immediate treatment before
the baby becomes sick. Usually the affected
babies are treated by modification of the diet
and/or avoidance of fasting. If the baby requires a
repeat test more information will be given about
the specific disorder which is suspected. Without
appropriate management, some disorders can
cause severe disability or death
Technique:
Various Immunological Techniques
Sample Type:
Blood Spot on filter paper
TAT:
7-10 days
Sample Report:
http://www.easternbiotech.com/reports/NBS.pdf
Within 24-48 hours of birth, find hidden disorder or condition
in your new born that needs early treatment.
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Insure®FIT™
Description:
InSure® FIT™ is a CLIA waived test that is available for
Physician Office Lab (POL) testing. To help improve
colorectal cancer screening compliance, InSure®FIT™
screening test offers high sensitivity and ease of use.
It is a highly patient-friendly water-Based collection
method. It’s patented brush sampling replaces
unpleasant fecal collection or smearing and there
are no dietary or medication restrictions. InSure®
FIT™ has 87% sensitivity for colorectal cancer & 98%
specificity. The test has a 66% increase in patient
compliance versus a guaiac-based fecal occult blood
test (gFOBT) based on a recent study1.
Application(s):
Physicians should talk to their patients about starting
colorectal cancer screening earlier and/or being
screened more often if they have any of the
following colorectal cancer risk factors:
• Personal history of colorectal cancer or adenomatous
polyps • Personal history of chronic inflammatory bowel disease
(Crohn’s disease or ulcerative colitis) • Strong family history of colorectal cancer or polyps (cancer
or polyps in a first-degree relative [parent, sibling, or child]
younger than 60 or in 2 or more first-degree relatives of
any age)
• Known family history of hereditary colorectal cancer
syndromes such as familial adenomatous polyposis (FAP)
or hereditary non-polyposis colon cancer (HNPCC)
A colorectal cancer screening test that your patient may
actually use
Technique:
Proprietary technology
Sample Type:
Stool in filter paper
TAT:
Less than 10 minutes
Sample Report:
http://www.easternbiotech.com/reports/IF.pdf
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2.
CLINICAL GENETICS
In general, Genetic testing refers to the examination of specific bits of DNA that have a known function, usually in a
protein-coding gene. Genetic testing requires that an investigator know which gene or genes to look at, based on some
prior understanding of the underlying biological contribution to a trait or disease.
Clinical (Medical) genetics is the branch of medicine that involves the diagnosis and management of hereditary disorders.
It also refers to the application of genetics to medical care such as diagnosis, management, and counselling people with
genetic
disorders would be considered part of medical genetics.
• TRIGENE Non Invasive Prenatal Test
• Parkinson-Alzheimer-Dementia Panel
• Diabetes/Obesity Panel • Pan Cardio Panel
• Retinal Degeneration Panel
• Targeted Mutation Screening
• Carrier Screening Test
• Inherited Disease Panel
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TRIGENE
Non Invasive Prenatal Test
Did you know that pieces of your baby’s DNA circulate in your
bloodstream? A simple blood test can tell doctors more about
your baby than ever before.
Description:
Non Invasive Prenatal Testing (NIPT) involves a simple
blood test that analyzes cell-free DNA, or cfDNA in
maternal blood to pinpoint baby’s risk for a number
of genetic disorders including Down syndrome. NIPT
is a screening test, which means it’s not “diagnostic”.
However it tells you the likelihood of your baby
having a disorder. But even though it can’t tell for
sure whether your baby has a genetic abnormality, it
is highly accurate. The results can help you and your
doctor decide next steps, including whether invasive
diagnostic tests — which are even more precise but
slightly increase the chance of miscarriage — are
worth the risk. The screening test can be done as
early as 10 Weeks of pregnancy.
Application(s):
•The Test is clinically validated for use in pregnant
women, of any age or risk category, to assess the
risk of fetal trisomy 21 (Down syndrome), trisomy
18 (Edwards Syndrome), & trisomy 13 (Patau
syndrome), and other common X & Y chromosomal
conditions.
Technique:
Microarray with proprietary DNA-based methodology
Sample Type:
10mL Maternal Peripheral blood
TAT:
10-14 Business Days
Sample Report:
http://www.easternbiotech.com/reports/NIPT.pdf
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Parkinson’s/Alzheimer’s/
Dementia Panel
In the general population, the risk to develop Parkinson’s/
Alzheimer’s/Dementia is estimated to be at least 10%
Description:
There are numerous genes associated with Dementia,
Alzheimer's and Parkinson's disease. While some of
them present particular manifestations that might
aid an accurate diagnosis, most of the time, the
clinical presentation exhibits common characteristics,
making difficult to establish a precise diagnosis.
Evidence shows that the conditions are the result of
a combination of genetic and environmental factors.
In the general population, the risk to develop any
of these conditions is estimated to be at least 10%.
This risk at least doubles for people with an affected
first degree relative. The risk can be estimated more
precisely when the genetic cause is known, given that
some mutations might confer a higher risk, including
early onset presentations. Learning about the genetic
risk for these conditions might be of utility for making
informed decisions related to medical management
and care of a patient and to identify who among the
direct family members is at higher or at lower risk.
Application(s):
•Considering the significant overlap between the
different types of dementia, Alzheimer and Parkinson,
identifying the underlying genetic cause can often
help to clarify the diagnosis, guide the development of
a personalized medical management plan, and avoid
unnecessary or ineffective treatments. Learning
about the genetic cause of the condition also allows
at-risk family members the option to have genetic
testing to determine if they may have the condition
and/or if they would benefit from additional medical
management.
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
4-6 weeks
Sample Report:
http://www.easternbiotech.com/reports/APDMR.pdf
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Diabetes/Obesity Panel
Description:
Diabetes is a group of not well-understood disorders
characterized by abnormal glucose levels. As a
complex disease, diabetes is the result of the interplay
between the individual’s genetic make-up and the
environment and there are multiple genes that are
known to be associated with this condition; thus, a
multigene panel represents a cost-effective option to
identify the genetic cause of diabetes.
Application(s):
•The clinical utility of genetic testing for diabetes is
based on its capacity to confirm the diagnosis and
predict the general clinical course of the condition.
•While a deregulated level of glucose is the common
trait for all cases of diabetes, some genetic
defects will result in additional manifestations
such as macrovascular complications or metabolic
syndrome. Identifying the subset of patients who
are at higher risk for these or other complications,
enables preventive interventions to reduce the
negative impact in the patient’s lives.
•Besides improving the management of the
individual, discovering of the genetic cause of
diabetes in a family allows the identification of
family members at risk even before the condition
manifests. •Given the genetic heterogeneity, a multigene
panel provides a cost-effective (time and money)
alternative that provides an answer in a shorter
time and at a lower price.
Technique:
NGS
Sample Type:
Whole Blood
TAT:
5-7 Weeks
Sample Report:
http://www.easternbiotech.com/reports/DOSR.pdf
Have you wondered how you developed diabetes? Do you
worry that your children will develop it too?
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Pan Cardio Panel
Description:
The Pan Cardio Panel is a comprehensive genetic
diagnostic tool developed to cover a wide spectrum
of heart related conditions, including arrhythmias
and cardiomyopathies. While there are some
heart conditions that have an identifiable clinical
presentations, some tend to exhibit a heterogeneous
phenotype with different responses to specific
treatments. Learning the genetic cause of a condition
enables clinicians to develop a personalized
management plan for each of their patients.
Application(s):
•Genetic testing allows the identification of the
genetic cause of conditions including hearth disease.
Identifying the underlying genetic cause can often
help to clarify the diagnosis, guide the development
of a personalized medical management plan, and
avoid unnecessary or ineffective Treatments.
Learning about the genetic cause of the condition
also allows at-risk family members the option to
have genetic testing to determine if they may have
the condition and/or if they would benefit from
additional medical management.
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/PCNP.pdf
Do you have a family history of heart problems? Identify the
mutated gene causing the disease
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Retinal Degeneration Panel
Retinitis Pigmentosa is the most common inherited cause
of blindness in people between the ages of 20 and 60
worldwide
(source: http://artificialretina.energy.gov/diseases.shtml)
Description:
Mutations in more than 60 genes are known to cause
nonsyndromic retinitis pigmentosa. Mutations in any
of the genes responsible for retinitis pigmentosa lead
to a gradual loss of rods and cones in the retina.
The progressive degeneration of these cells causes
the characteristic pattern of vision loss that occurs
in people with retinitis pigmentosa. Rods typically
break down before cones, which is why night vision
impairment is usually the first sign of the disorder.
Daytime vision is disrupted later, as both rods and
cones are lost. Retinitis pigmentosa often has
an autosomal dominant, or autosomal recessive , or
X-linked pattern.
Application(s):
•Inherited eye disorders are important causes of
vision loss. It is desirable to obtain genetic diagnoses
for patients with these disorders, as this information
can influence patient care by both informing genetic
risk assessment and identifying patients who would
benefit from novel gene-based therapies
Technique:
NGS (Full sequencing)
Sample Type:
Whole Blood
TAT:
6-8 weeks
Sample Report:
http://www.easternbiotech.com/reports/RDPG.pdf
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Targeted Mutation Screening
Also known as Familial Mutation Testing, It is used as a
diagnostic testing for specific conditions when one or more
mutations have been identified in a family member
Description:
The test identifies the mutated gene or genes causing
a genetic disease in your family. The identification
of a gene mutation(s) allows for further steps to be
taken to prevent the passing on of the condition to
future generations and may aid in the improvement
of treatment of an affected individual.
Application(s):
•Mutation screening for a known mutation such as
Thalassemia, Sickle cell Anemia, Spinal Muscular
Atrophy, Sanjad Sakati and more.
•Screening can be done for any other known
mutation as well
•You have the genetic report of a family member and
would like to be screened for the same mutation.
•The gene causing the genetic condition affecting
your family is of small size (less than 5 exons).
•Examples include Beta Thalassemia, Connexin 26
(hearing loss) and more.
Technique:
Sanger
Sample Type:
Whole Blood
TAT:
6-8 business days
Sample Report:
http://www.easternbiotech.com/reports/TMS.pdf
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Carrier Screening Test
Identify what mutations you and your partner could have,
get carrier screening before pregnancy to understand your
options earlier on!
Description:
Carrier screening analyzes 571 unique genes for
mutations that are known to cause 210 genetic
conditions encompassing more than 400 genetic
diseases. The majority of the conditions included
in Carrier Screening are inherited in an autosomal
recessive pattern.
Application(s):
•Recommended in cases of consanguineous
marriage, history of any genetic condition in the
family
•Test allows future parents to find out if they are a
carrier for a genetic disorder
•Carrier screening is performed for genetic
diseases that are inherited in an Autosomal
Recessive or X-linked manner
•Can also identify genetic disorders in people of a
particular ethnicity
Technique:
NGS (Full Sequencing)
Sample Type:
Whole Blood
TAT:
4-5 weeks
Sample Report:
http://www.easternbiotech.com/reports/CS.pdf
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Inherited Disease Panel
Have an inherited genetic condition or disease? Confirm
the diagnosis of the genetic condition and guide yourself to
proper disease management.
Description:
Broad genetic survey test for investigating general
susceptibility and/or carrier condition for the included
Mendelian disorders. 300 genes associated with
>700 inherited diseases, including neuromuscular,
metabolic, cardiovascular, and developmental
diseases.
Application(s):
•Pre-conceptional test for couples – Testing done
before trying for a baby to understand if there is any
risk of passing any inherited disease(s) to the baby.
•Genetic screening of gamete donors
•The test can be done by a patient who is concerned
about family history or a particular disease
Technique:
NGS (Full Sequencing)
Sample Type:
Whole Blood
TAT:
4-5 Weeks
Sample Report:
http://www.easternbiotech.com/reports/IDP.pdf
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3.
CLINICAL GENOMICS
Genomic testing, on the other hand, looks for variations within large segments across
the entirety of genetic material, both within and outside known functional genes.
Investigators don't usually need to have a target gene in mind or any prior knowledge of
the underlying biology of a trait when doing genomic testing. However, genomic testing
produces large amounts of data that must be processed to tease out genetic variants of
significance to a particular trait.
• Whole Exome Sequencing
• Whole Genome Sequencing
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Whole Exome Sequencing
Description:
Less than 2% of whole genome is known to be
protein-coding region, known as Exome. Over 85% of
known genetic variants are within this region. Exome
sequencing is selective sequencing of the coding
regions of the genome, after the Exome has been
efficiently captured.
Application(s):
•Whole Exome Sequencing is performed for
many different clinical Indications. It offers a
more comprehensive coverage of the “known”
phenotype-specific genes. The clinical usefulness
of varies for different disorders. In the majority
of cases, the finding does not alter the clinical
management, treatment or prognosis. However,
it does allow an end to an expensive and stressful
diagnostic odyssey. Reaching a molecular diagnosis
allows the clinician to allay the guilt that patients
can face in the absence of a firm diagnosis. More
importantly, it facilitates genetic counseling and
allows for more accurate estimates of recurrence
risk in the family. Identification of the molecular
etiology allows the clinician to guide subsequent
pregnancies, either through prenatal diagnostics or
pre implantation genetic diagnosis.
Technique:
NGS
Sample Type:
Whole Blood
TAT:
4-6 weeks
Sample Report:
http://www.easternbiotech.com/reports/WES.pdf
One of the most extensive genetic tests available, may
help find a genetic cause for you or your child’s signs and
symptoms even if previous genetic testing did not!
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Whole Genome Sequencing
Want to determine your entire DNA sequence at one shot?
Description:
Human whole genome has approximately 3 billion
base pairs of nucleotides. The first human whole
genome sequencing (hWGS) was completed and
publisehd in 2001. Since then, hWGS is widely studied
in the filed of biomedical science, anthropology,
forensics and many more. Individual variations,
such as single nucleotide polymorphism(SNP), copy
number variation (CNV) and structural variations (SV),
can be identified by whole genome re-sequencing.
Application(s):
•Clinical application of hWGS is the next step in the
progression to complete elucidation of the genomic
determinants of a patient’s heritable make-up.
WGS can provide insights into known and unknown
variations in approximately 95% of the individual’s
genome. Hence it substantially increases the
volume of detected variants.
Technique:
NGS
Sample Type:
Whole Blood
TAT:
6-8 weeks
Sample Report:
Contact us for details
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CANCER GENETICS
Over the past decade, we have witnessed a revolution in sequencing technologies
that has had a profound impact on our understanding of genetics and genome
biology. The next generation sequencing technology (NGS) has thus provided a great
potential in the management and treatment of human health bridging to a new era
of molecular pathology and personalized medicine. Eastern Biotech & life sciences
proudly adds to its portfolio several NEW Cancer Genetic tests that will use the
Next Generation Sequencing (NGS) technology. The cutting-edge technology utilizes
a multi-target approach to detect mutation in specific genes & be able to detect
various cancers.
• BRCA1/2 Full Sequencing with Deletion & Duplication
• BRCAPlus™
• BreastNext™
• ColoNext™
• GynPlus™
• Comprehensive Cancer Panel
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BRCA1/2 Full Sequencing
with Deletion & Duplication
Mutations in the BRCA1 and BRCA2 genes are the most
common causes of hereditary breast and ovarian cancers
Description:
BRCA1 and BRCA2 are tumor suppressor genes that
have an essential role in both DNA repair and cell cycle
control
systems.
Germline BRCA1
and
BRCA2 mutations are implicated in 25-50% of
hereditary breast cancer Cases. The genetic test
analyzes the BRCA1 and BRCA2 genes to identify
any inherited changes (mutations) in them that can
increase the risk for cancer.
Application(s):
BRCA1/2 testing may be considered for individuals
with a personal or family history of any of the
following: •Early-onset breast cancer (<45 years-of-age) or
bilateral breast cancer
•Two primary breast cancers or clustering of breast
and ovarian cancer
•Presence of male breast cancer
•Ovarian cancer at any age
•At-risk populations (e.g. Ashkenazi Jewish descent)
Technique:
Sanger + Deletion/Duplication Analysis
Sample Type:
Whole Blood
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/BRCA1_2.pdf
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BRCAPlus™
Description:
BRCAPlus™ is a next generation sequencing panel
of 6 genes associated with breast cancer (BRCA1,
BRCA2, CDH1, PALB2, PTEN, and TP53). These six
genes are associated with five hereditary cancer
syndromes (hereditary breast and ovarian cancer or
HBOC, hereditary diffuse gastric cancer, hereditary
breast and pancreatic cancer, Cowden syndrome, and
Li-Fraumeni syndrome).
Application(s):
•Indications for Testing
• Families with a combination of the cancers below and some
common red flags for hereditary cancer in the family would be
appropriate to consider for BRCAplus testing:
• Early-onset breast cancer (diagnosed ≤45 years of age)
• Male breast cancer at any age
• Breast and ovarian cancer in the same woman
• Three or more cases of breast cancer*
• Three or more cases of breast, uterine, and/or thyroid cancer*
*On the same side of the family
•Common Red Flags for Hereditary Cancer
• Cancer diagnosed at a younger age than expected for the general
population (≤ 50 years, for most cancers)
• Cancer diagnosed across generations, and in multiple generations
within a family, especially if diagnosed younger than average
• Individual with multiple primary cancers (either in paired organs or
in different organs)
• A pattern of cancer in the family that is typical of a known cancer
predisposition syndrome (e.g.breast and diffuse gastric cancer
with CDH1mutations, or breast and thyroid cancer with PTEN
mutations) Family with a combination of Breast, Uterine, Thyroid should
consider BRCAPlus
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
3-4 Weeks
Sample Report:
http://www.easternbiotech.com/reports/BRCAplus.pdf
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BreastNext™
Description:
BreastNext™ is a next generation sequencing (NGS)
panel that simultaneously analyzes 17 genes (ATM,
BARD1, BRCA1, BRCA2, BRIP1, CDH1, CHEK2,
MRE11A, MUTYH, NBN, NF1, PALB2, PTEN, RAD50,
RAD51C, RAD51D, and TP53) associated with increased
risk for breast cancer, including BRCA1 and BRCA2.
Mutations in the genes on the BreastNext panel
can confer an estimated 20–87% lifetime risk for
breast cancer. Some of these genes have also been
associated with increased risks for other cancers, such
as pancreatic cancer, ovarian cancer, and sarcoma
Application(s):
• Indications for Testing
Families with a combination of the cancers below and some
common red flags for hereditary cancer in the family would
be appropriate to consider for BreastNext testing.
• Early-onset breast cancer (diagnosed ≤45 years of age)
• Male breast cancer at any age
• Breast and ovarian cancer in the same woman
• Three or more cases of breast cancer*
• Three or more cases of breast, ovarian, and/or pancreatic cancer*
• Three or more cases of breast, uterine, and/or thyroid cancer*
*On the same side of the family
Most comprehensive panel to understand predisposition
for Breast Cancer. Also includes Ovarian, Uterine, Thyroid,
Pancreatic, Sarcoma etc
•Common Red Flags for Hereditary Cancer
• Cancer diagnosed at a younger age than expected for the general
population (≤ 50 years, for most cancers)
• Cancer diagnosed across generations, and in multiple generations
within a family, especially if diagnosed younger than average
• Individual with multiple primary cancers (either in paired organs or
in different organs)
• A pattern of cancer in the family that is typical of a known cancer
predisposition syndrome
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
3-5 Weeks
Sample Report:
http://www.easternbiotech.com/reports/BN.pdf
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ColoNext™
Description:
ColoNext™ is a next generation sequencing (NGS)
panel that simultaneously analyzes 17 genes (APC,
BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1,
MSH2, MSH6, MUTYH, PMS2, POLD1, POLE, PTEN,
SMAD4, STK11, and TP53 ) associated with increased
risk for colorectal cancer. Full gene sequencing is
performed for 15 of the genes. Gross deletion/
duplication analysis is performed for all 17 genes.
Specific site Analysis is available for individual gene
mutations identified in a family.
Application(s):
•Indications for Testing
• ColoNext may be appropriate in the following situations, combined
with common red flags for hereditary cancer:
• Early-onset colorectal cancer (diagnosed < 50 years of age)
• Multiple primary cancers in one person (e.g. two primary colorectal
cancers or colorectal and uterine cancer)
• 3 or more family members with colorectal, uterine, ovarian, and/
or stomach cancer
• 10 or more GI polyps during one’s lifetime (adenomatous,
hyperplastic, hamartomatous, and/or other types of polyps)
• A family history suspicious for several different hereditary
colorectal cancer syndromes
• Previous uninformative genetic testing for hereditary colorectal
cancer
Colorectal cancer (CRC) affects about 1 in 20 (5%) men and
women in their lifetime. Find out your predisposition to the
cancer!
•Common Red Flags for Hereditary Cancer
• Cancer diagnosed at a younger age than expected for the general
population (≤ 50 years, for most cancers)
• Cancer diagnosed across generations, and in multiple generations
within a family, especially if diagnosed younger than average
• Individual with multiple primary cancers (either in paired organs or
in different organs)
• A pattern of cancer in the family that is typical of a known cancer
predisposition syndrome (e.g. colorectal and uterine cancer in
Lynch syndrome, or diffuse gastric cancer and lobular breast cancer
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
3-5 Weeks
Sample Report:
http://www.easternbiotech.com/reports/CN.pdf
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GynPlus™
Description:
GynPlus is a next generation sequencing panel that
simultaneously analyzes 9 high-risk ovarian and
uterine cancer susceptibility genes Genes on this
panel include BRCA1, BRCA2, EPCAM, MLH1, MSH2,
MSH6, PMS2, PTEN, and TP53. These nine genes are
associated with four hereditary cancer syndromes
(hereditary breast and ovarian cancer (HBOC), Lynch
syndrome, Cowden syndrome, and Li-Fraumeni
syndrome, all of which have published management
guidelines. Identification of a mutation in one of
these genes can help estimate cancer risk and guide
treatment, screening, and/or prevention decisions for
the patient.
Application(s):
•Indications for Testing
Lifetime risk for hereditary uterine cancer is 60% and
ovarian is 40%. Take the test to find your predisposition to
gynecological cancers!
• Families with a combination of the cancers below and some
common red flags for hereditary cancer in the family would be
appropriate to consider for GYNplus .
• Ovarian cancer at any age
• Early onset uterine cancer (diagnosed < 50 years of age)
• Multiple primary cancers in one person (e.g. uterine and breast or
thyroid cancer)
• Multiple close family members with ovarian or uterine and other
cancers (on the same side of the family)
• Cancer histories that are suspicious for both HBOC and Lynch
syndrome
•Common Red Flags for Hereditary Cancer
• Cancer diagnosed at a younger age than expected for the general
population (≤ 50 years, for most cancers)
• Cancer diagnosed across generations, and in multiple generations
within a family, especially if diagnosed younger than average
• Individual with multiple primary cancers (either in paired organs or in
different organs)
• A pattern of cancer in the family that is typical of a known cancer
predisposition syndrome (for example colon and uterine cancer in Lynch
syndrome, or breast cancer and sarcoma with a TP53 mutation) Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
3-5 weeks
Sample Report:
http://www.easternbiotech.com/reports/GP.pdf
30
Comprehensive Cancer Panel
Description:
Comprehensive Cancer Panel is a next generation
full gene sequencing hereditary cancer panel that
simultaneously analyzes 122 genes associated with
the most common 15 hereditary cancers such as
Breast, Ovarian, Colorectal, Endometrial, Melanoma,
Pancreatic, Gastric, Prostrate, Thyroid, and many more.
About 10% of all cancer cases are due to hereditary
cancer. The identification of the genetic cause of
cancer in these patients allows the development of
a personalized plan for clinical management for the
affected patient and family members.
Application(s):
•Genetic testing for cancer is recommended for patients
with a personal or a family history suggestive of
hereditary cancer: Patients with cancer at an early
age or with bilateral (more than one primary) cancer
or patients with several family members with similar
cancer or other manifestations provocative of cancer
syndromes.
•The identification of the gene responsible for the
observed cancer might influence the treatment of the
cancer patient (radiotherapy, surgical or pharmacological
management).
•Some mutations are associated with several types of
cancer, therefore the identification of the affected gene
will result in a preventive plan that involves the different
organs that might be affected.
•When the family mutation is known, unaffected
individuals can be tested to start risk-reducing
interventions before any cancer manifestation.
Technique:
NGS (Full sequencing with del/dup)
Sample Type:
Whole Blood
TAT:
4-6 weeks
Sample Report:
http://www.easternbiotech.com/reports/CCP.pdf
An ideal diagnostic tool for patients with non-specific,
personal, or family cancer histories.
31
32
5.
WELLNESS/ANTI AGING /
LIFESTYLE GENETICS TESTS
Your Genetics are a Road Map to Health and Wellness. Through the study and use of genetics, we can identify measures
that could lead to the improvement of human health and wellness. These measures and procedures aim to prevent years
of chronic disease and thousands of dollars in health care costs, and provide families and communities with knowledge
of how to live healthier.
Anti-aging medicine is the pinnacle of biotechnology joined with advanced clinical preventive medicine. The specialty is
founded on the application of advanced scientific and medical technologies for the early detection, prevention, treatment,
and reversal of age-related dysfunction, disorders, and diseases. The anti-aging medical model aims to both extend
lifespan as well as prolong health span. To support the anti aging medical model, Eastern Biotech & life sciences has added
several specialty profiles that will help individuals manage & improve their health to live productively and independently.
• Geneus™
• Telomere Test
• Karmagenes
• SkinCareDNA
• Fitness & Diet Genetic Test
• GPL SNP1000
33
Geneus™
Screen your DNA for the presence of 2,205 SNPs and
mutations associated with 350+ medical conditions. Description:
Geneus™ is a genetic screening test that analyzes
your DNA for two types of genetic sequence
changes: Single Nucleotide Polymorphisms (SNPs),
and mutations. Through blood test, Geneus™
screens your DNA for the presence of 2,205 SNPs
and mutations with known associations with over
350 medical conditions. The presence of a SNP or
mutation in your DNA will not change over the course
of your lifetime, making Geneus™ a once in a lifetime
screening test.
Application(s):
•Your DNA will be screened for Ancestry, Age
related conditions, Allergies & Immune conditions,
Cancers, Diabetes, Heart related conditions, HLA
typing, Infertility & Reproductive health, Intellectual
Abilities & Social Behavior, Liver & Kidney conditions,
Metabolism & Eating Habits, Ophthalmological
disorders, Thrombosis, Blood Clots & Bleeding
disorders, & Other condition such as Male Baldness,
Sleep Apnea, Restless Legs Syndrome etc.
Technique:
NGS
Sample Type:
Whole Blood
TAT:
4-6 weeks
Sample Report:
http://www.easternbiotech.com/reports/Geneus.pdf
34
Telomere Test
Description:
Telomeres are the ends of chromosomes, which
have an essential role in protecting their integrity
in the process of cellular replication.The function
of telomeres is to protect chromosome ends from
chromosome fusions and degradation, therefore,
ensuring the proper functionality and viability of cells.
Thus, telomere length serves as the biomarker of the
cell replicative capacity, which defines the biological
age of the individual.
Knowing the biological age is an excellent indicator
of individuals’ overall general health status.
Secondly, knowing our biological age permits us to
obtain a better understanding of the lifestyle habits
that impact our aging process. This affords us the
opportunity to make appropriate changes and through
periodic re-testing measure the results. Thirdly, Life
Length’s Telomere Analysis Technology® (TAT®), will
allow for more personalized medicine as doctors
increasingly treat patients taking into consideration
their biological age.
Application(s):
Telomere testing is a valuable emerging diagnostic
tool within the area of functional and preventive/
personalized medicine with a number
of clinical applications including:
•An overall global biomarker of health and the
programs and treatments designed to optimize
healthy aging
•Early detection of chronic/age-related diseases
•Stratifying risk
•Prognosis determination
•And for tailoring treatments
Technique:
Telomere Analysis Technology®
Sample Type:
Blood in EDTA
TAT:
6-8 weeks
Sample Report:
http://www.easternbiotech.com/reports/TTSR.pdf
Anti Aging starts with the Telomere Test
35
Karmagenes Test
Description:
How much - Optimist, Spontaneous, Social, Confident,
Innovative, Self-Aware, Risk Taker, Stress Tolerant,
Calm, Emotional, Strategic, Bon Vivant, Decisive
- are you? Your personality is the result of the long
interplay between your DNA, your cultural and social
environment ,and the decisions and experiences
you get along the road. In other words, a healthy
mixture of Nature (DNA and Objectivity) and Nurture
(Environment and Perception).
Karmagenes offers the first DNA-based personality
test. Its top-notch biotechnology links DNA from your
saliva sample with 14 behavioral characteristics to
define the role of DNA and Environment in shaping
our current behavior.
Application(s):
•If you want to know what "Be Yourself" finally
means? Get Karmagenes genetic test and figure out
what is the hidden potential in your DNA.
•The test allows seeing the differences between your
genes and your environment, a really valuable tool
that can be helpful to better know your personality's
strengths and weaknesses, so you can improve
where necessary.
Technique:
PCR
Sample Type:
Buccal (Cheek) Swab
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/KG.pdf
Integrating genetics & psychology for personal development
36
SkinCareDNA
Description:
There are literally thousands of different skin care
products available for consumers today. It is quite
an emotionally distressing experience to choose the
right product for your skin. Remove any guesswork!
Instead use your genetics to get to the Bottom of
your skin’s physiology and identify the most suitable
skincare product for you.
SkinCareDNA™ a revolutionary DNA test examines 16
genetic markers (SNPs) in the following categories
associated with skin aging.
•Firmness + Elasticity
•Wrinkling (A.G.E.)
•Sun Damage + Pigmentation
•Free Radical Damage
•Sensitivity + Inflammation
Application(s):
Results from the test are used to scientifically create a
personalized guide that will provide you with a unique
regime tailored specifically to you. This test allows
you to not depend on ‘one-size-fits-all’ suggestions
and enables using the right skincare products based
on your skin’s genetic blueprint.
Technique:
SNP array
Sample Type:
Buccal (Cheek) Swab
TAT:
3-4 Weeks
Sample Report:
http://www.easternbiotech.com/reports/SCD.pdf
Get to the bottom of your skin’s physiology and understand
which ingredient is right for your skin!
37
Fitness & Diet Genetic Test
Tailor your workout & diet based on what your genes say!
Description:
Due to our genetic makeup, we are all different in
many ways. There are the physicial differences such
as eye and hair color, but then there are the differences
inside us such as how we metabolize nutrients, the
way we deal with toxins etc. We all interact with the
environment in our own unique way. The fitness &
diet genetic test helps identify an individual’s genetic
predisposition for sporting or fitness profile, idea diet,
and personal nutrition needs based entirely on genes.
Application(s):
•To better understand their nutrition requirement
•To reduce injury rate during workout or athletic
training
•To increase fitness performance
•To avoid over training in the gym
Technique:
PCR
Sample Type:
Buccal (Cheek) Swab
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/FDGT.pdf
38
GPL SNP1000
Description:
GPL SNP1000 is the most comprehensive test for
alterations in the genetic code in the pathways that
are most important for integrative medicine. This test
looks at nine core groups of genes which are crucial
for many different biological pathways. Previous to
GPL-SNP1000, most genetic tests have only looked
at a small subset of genes and very few SNPs (singlenucleotide polymorphisms). GPL-SNP1000 includes
over 1,000 different SNPs and over 144 different
genes. Here are the pathways that GPL-SNP1000
assesses:
• DNA Methylation
• Oxalate Metabolism
• Mental Disorders / SAM-E/B12 Metabolism
• Gluten Opioid Peptide Homeostasis
• Autism Spectrum Genes
• P450s (cyps)
• Cholesterol Deficiency
• Acetaminophen Toxification/Detoxification
• Transporters
9 specific pathways most important for Functional &
Integrative medicine!
Application(s):
•GPL-SNP1000 will help you understand how these
nine genetic pathways are performing. These
pathways have been specifically selected because
of their importance in overall health. This test will
help you understand your risks for developing
different disorders such as ADHD, Adverse Drug
Reactions, Allergies, Anxiety, Arthritis, Autism
Spectrum Disorders, Bipolar Disorder, Cancer,
Depression, Heart Disease, Osteoporosis, Oxidative
Stress, Schizophrenia and more
Technique:
NGS
Sample Type:
Whole Blood
TAT:
6-8 weeks
Sample Report:
http://www.easternbiotech.com/reports/G-S1000.pdf
39
40
6.
WELLNESS/ANTI AGING/
LIFESTYLE NON GENETIC TESTS
Anti-aging medicine is the pinnacle of biotechnology joined with Advanced clinical preventive medicine. The specialty is
founded on application of advanced scientific and medical technologies for the early detection, prevention, treatment,
and reversal of age-related dysfunction, disorders, and diseases. The anti-aging medical model
aims to both extend lifespan as well as prolong health span. To support the anti aging medical model, Eastern Biotech
& life sciences has added several specialty profiles that will help individuals manage & improve their health to live
productively and independently.
• Food Intolerance Test (FOODWatch)
• Food Allergy Test
• Executive Wellness Profile
• Organic Acid Test
• Comprehensive Stool Analysis
• Gluten/Casein Peptides Test
• Weight Management Profile
• Skin Vitality Profile
• Sleep Balance Profile
• Adrenal Stress Profile
• Fertility Profile
• Cardio Metabolic Profile
• Neurotransmitters
• Urine Hormones Metabolites
• Metals Hair Test
41
FOODWatch
Food Intolerance Test
Narrow the specific intolerance to a particular group of foods
Description:
Food intolerance is an adverse reaction to a particular
food, it involves the immune system, and is a less
intense reaction. The symptoms can be unpleasant
and in some cases severe but are generally not
life-threatening. We offer comprehensive panel for
food intolerance (200 plus parameters) which are a
combination of various groups of foods that help to
narrow the specific intolerance to a particular group
of foods.
Application(s):
Individuals who believe they have an intolerance
against a number of foods that create respiratory
issues, neural issues, affects their immune system,
hair, skin, nails, metabolic problems, musculo skeletal
problems, malabsorption problems, gastro-intestinal
problems, genital and/or reproductive problems
Technique:
Microarray Technology
•Mini 30 Panel (Meat/Dry Fruits/Fruits/Cereals)
Test Options:
•Mini 30 Panel (Vegetarian & Diary)
•Grande 210 Panel (Comprehensive)
Sample Type:
Whole Blood
TAT:
3-4 business days based on the panel
Sample Report:
http://www.easternbiotech.com/reports/FWatch.pdf
42
Food Allergy Panel
Allergic reaction to a food can be severe or life-threatening as
it usually involves the immune system and affects numerous
organs in the body
Description:
Food allergy occurs when the body’s immune system
reacts to a protein in a certain food, causing the
release of antibodies and histamine. The release of
histamine causes symptoms. Allergy symptoms can
begin within minutes to 2 hours of eating the problem
food. Symptoms can vary from mild to severe. Even
tiny amounts of a problem food can cause serious
reactions in very sensitive people. Occasionally, a
very severe, rapidly progressing and life-threatening
allergic reaction, known as anaphylaxis, can occur.
This requires immediate first aid treatment, for
example with an EpiPen adrenaline injection. True
food allergy is most common in children, but only
affects about 1% of adults. Most children will grow out
of food allergies by school age, although seafood and
nut allergies tend to be life-long.
Application(s):
Test can be used when someone has Oral Allergies,
Impaired digestion, Leaky Gut,hereditary allergies
in the family, Dizziness and Nausea, Vommitting or
Diarrhea immediately after eating a food.
Technique:
Based on the panel
Test Options:
•Food Allergy Panels (20 Allergens & 44 Allergens)
•Respiratory Allergy Panels (20 Allergens & 44 Allergens)
Sample Type:
Whole Blood
TAT:
1-5 business days based on the panel
Sample Report:
http://www.easternbiotech.com/reports/FA.pdf
43
Executive Wellness Profile
Description:
In today’s busy lifestyle of excessive work hours and
fast paced environment, and maintaining a work-life
balance, we are constantly negotiating the little
time we have. We go week after week without
paying particular attention to what we eat and find
no time for proper exercise. In juggling all these
responsibilities, it is hard to monitor one’s health
unless we do a regular Health Check. We are aware
that such a lifestyle predisposes us to the classic trait
of lifestyle diseases such as diabetes, hypertension,
heart disease and excess weight. Hence by doing an
Executive Wellness check periodically at Eastern, we
are confident that you will have the necessary data to
be able to keep a check on your health and proactively
take any required steps to live a better healthier
lifestyle.
Application(s):
• Liver Profile (11)
• Kidney Profile (5)
• Iron Deficiency Profile (3)
• Thyroid Profile(3)
• Diabetic Screen (2)
• CBC (28)
• Testosterone
Technique:
Several Immunological & biochemical techniques
Sample Type:
Whole Blood
TAT:
5-7 days+ shipping
Sample Report:
http://www.easternbiotech.com/reports/EWP.pdf
A snapshot of your current health & lifestyle!
• Cardiac Risk Markers (6)
• Ferritin, Arthritis (2)
• Electrolytes (2)
• Vitamins (3)
• Cholesterol Profile (8)
• Pancreas (2)
44
Organic Acid Test (OAT)
Description:
The Organic Acids Test (OAT) provides an accurate
evaluation of intestinal yeast and bacteria. The test
includes 74 urinary metabolite markers that can
be very useful for discovering underlying causes
of chronic illness such as behavior disorders,
hyperactivity, movement disorders, fatigue and
immune function. The cause of these high levels
could include: oral antibiotic use, high sugar diets,
immune deficiencies, and genetic factors. The OAT is
strongly recommended as the initial screening test.
The Microbial Organic Acids Test (MOAT) is ideal for
follow-up to the OAT and is often recommended by
practitioners looking for a specific abnormality, to
monitor certain microbial imbalances, or to assess
treatment efficacy.
Application(s):
The test can be used to
•Evaluate energy production
•Assess central nervous system function
•Reveal high levels of GI yeast and bacteria
•Detect nutritional and antioxidant deficiencies
•Determine problems in fatty acid metabolism
•Identify excess oxalate
Technique:
Gas Chromatography/Mass Spectrometry (GC/MS)
Sample Type:
Urine
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/OAT.pdf
Use the metabolic markers in OAT to treat nutrient deficiencies
& chronic illnesses
45
Comprehensive Stool Analysis
Description:
Many chronic disorders come from digestive
problems and inadequate nutrient absorption. Proper
gastrointestinal function is needed to eliminate toxic
substances, pathogenic microbes, and undigested
food particles from the body to prevent health
problems. Nutrients require a specific internal
environment to be properly digested and transported
throughout the body. The comprehensive stool
digestive analysis (CSDA) detects the presence of
pathogenic microorganisms such as yeast, parasites,
and bacteria that contribute to chronic illness
and neurological dysfunction. It provides helpful
information about prescription and natural products
effective against specific strains detected in the
sample.
Application(s):
The test is useful in the diagnosis of intestinal
dysfunction without invasive procedures. The test
can be used to
•Isolate & identify many different pathogens
•Assess digestive problems and inadequate nutrient
absorption
•Determine any abnormal intestinal microorganisms
in the GI tract
•Determine the amount of beneficial bacteria levels
in the GI tract, intestinal immune function, overall
intestinal health, and identify inflammation markers
Technique:
Multiple immunological techniques
Sample Type:
Stool
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/CSA.pdf
CSDA is an overall assessment of the patient’s digestive system
46
Gluten/Casein Peptides Test
Description:
The Gluten/Casein Peptides Test can determine
the inability to digest wheat, rye, barley, and milk.
These undigested proteins, called peptides, are
associated with gastrointestinal, neurological, and
neuro-Developmental disorders. The Gluten/Casein
Peptides Test determines sensitivities, even when a
patient has no IgE or IgG allergic reactions to these
foods. If either of the peptide results is abnormal,
both gluten (from gliadorphin) and casein (from
casomorphin) should be eliminated.
Application(s):
This test is a very useful tool in determining whether
dietary modifications should be part of an integrated
treatment plan, or whether the diet should be
maintained. It is recommended for the following
disorders:
•
•
•
•
•
•
•
•
•
Assess the elevated amounts of peptides (Gluten & Casein)
that can cause an opiate-like effect
AD(H)D
AIDS
Alzheimer’s Disease
Arthritis
Autism Spectrum Disorders
Chronic Fatigue Syndrome
Colitis & Crohn’s Disease
Depression
Diarrhea/Constipation
•
•
•
•
•
•
•
•
•
Down Syndrome
Fibromyalgia
Behavioral Disorders
Multiple Sclerosis
OCD
Psychoses
Schizophrenia
Tic Disorder
Tourette Syndrome
Technique:
Elisa
Sample Type:
Urine
TAT:
3-4 weeks
Sample Report:
http://www.easternbiotech.com/reports/GCP.pdf
47
Weight Management Profile
Description:
The Weight Management Profile can detect key
hormone imbalances that undermine patients' best
efforts to control their weight. It identifies hormonal
imbalances that contribute to obesity, weight gain,
difficulty losing or sustaining a healthy weight, slowed
metabolism, increased body fat deposition, and food/
sugar cravings. Used as a screening tool, it serves as
an early indicator, of insulin resistance and risks for
metabolic syndrome and diabetes.
Application(s):
•Test can be used for Women with premenstrual
weight gain and fluid retention; perimenopausal
and/ or menopausal weight gain in hips/thigh, and/
or inability to lose/tendency to regain weight, central
obesity, PCOS, adrenal and thyroid dysfunction;
breast cancer risks.
•Test can be used for MEN with andropausal weight
gain in hips/thighs and/or inability to lose/tendency
to regain weight, central obesity, adrenal and thyroid
dysfunction; prostate cancer risks.
Can’t lose weight? Identify the hormonal imbalances causing
your weight gain!
• Optional Thyroid Add-on: free T3, free T4, and TPOab antibodies
provide a better estimation of thyroid hormone bioavailability to
facilitate effective thyroid therapy. Consider when symptoms of
thyroid deficiency are problematic.
• Optional Cardio Add-on: Cardiometabolic risk markers hs-CRP,
triglycerides, total cholesterol, LDL, HDL and VLDL cholesterol for
early detection of pro-inflammatory CVD risks and prediabetes.
•Consider test for abdominal obesity, and symptoms
of insulin resistance/metabolic syndrome
Technique:
Multiple Immunological Techniques
Sample Type:
Saliva & Blood Spot
TAT:
5-10 business days
Sample Report:
http://www.easternbiotech.com/reports/WMP.pdf
48
Skin Vitality Profile
Discover the hormonal connection that is vital to youthful skin.
Description:
Skin is not only a major target of hormone action, it
is also a site of local hormone synthesis, activation and
metabolism. The range of hormones tested in the Skin
Vitality Profile can help providers identify hormone
deficiencies or excesses that are contributing to skin
problems.
Application(s):
•Consider test for patients with thinning skin,
wrinkling, dryness, oiliness, acne, hirsutism, hair
loss, melasma, itching, myxedema, or slow wound
healing.
Technique:
Multiple immunological techniques
Sample Type:
Saliva & Blood Spot
TAT:
5-10 business days
Sample Report:
http://www.easternbiotech.com/reports/SVP.pdf
49
Sleep Balance Profile
Description:
When the master stress hormone cortisol is
chronically elevated, particularly at night, it inhibits
sleep and leads to lower melatonin levels. In addition
to stress-related sleep disturbances, melatonin
levels naturally dine as we age – triggering further
imbalances. The Sleep Balance Profile – the first
four-point test offers a complete diurnal pattern of
melatonin and cortisol to help patients struggling
with hormone-related sleep imbalances.
Application(s):
•The Sleep Balance profile allows patients to find
the source of troublesome sleep problems offering
long-term treatment solutions.
•The test can be used for patients with inability to
get to sleep, chronic sleeplessness affecting vitality,
frequent waking, cognition, weight, diabetes, and
cardiovascular risks.
•The test allows physicians to pin point imbalance of
melatonin and cortisol circadian rhythms associated
with acute or chronic sleep disturbances.
Uncover hidden barriers to a restful sleep
Technique:
Liquid Chromatography/Tandem Mass Spectrometry
(LC-MS/MS)
Sample Type:
Dried Urine
TAT:
5-10 Business Days
Sample Report:
http://www.easternbiotech.com/reports/SBP.pdf
50
Adrenal Stress Profile
Find out if stress hormones are out of balance to effectively
manage your stress.
Description:
The Adrenal Stress profile measures the DHEA
and diurnal Cortisols, and is the accepted industry
standard for evaluating adrenal health. Samples
collected at four critical time points in one day provide
a useful picture of adrenal function to help patients
dealing with stress-related symptoms and disorders.
The difference between stress we can handle and
stress that gets out of hand is the difference between
adrenal balance or imbalance. Both high and lows of
the key adrenal hormones, DHEA and Cortisol, can
play havoc with body systems and related hormones
– triggering further imbalances.
Application(s):
•The profile is used to determine if your adrenal
functions are burnt out and if you are suffering from
adrenal fatigue.
•It allows you to find the source of adrenal imbalances
underlying patient symptoms, offering long-term
treatment solutions.
Technique:
Enzyme Immunoassay (EIA)
Sample Type:
Saliva
TAT:
5-10 Business Days
Sample Report:
http://www.easternbiotech.com/reports/ASP.pdf
51
Fertility Profile
Description:
The profile provides a thorough evaluation that
can identify many problems related to hormone
imbalances that affect fertility. Early detection
can help your patients address those issues and
identify the need for more specialized care. Patients
can collect their samples conveniently and at the
appropriate cycle times with minimal disruption to
their lives and busy work schedules. Sampling is done
on days 3 and 21 of the menstrual cycle. Dried blood
spot samples are collected on days 3 and 21 of the
menstrual cycle, and saliva samples are collected only
on day 21. The day 3 sample is optimal for assessment
of ovarian reserves with the FSH and LH tests, while
the other hormones are measured mid-luteally (day
21 commonly), when the level of hormones should
be optimal for a successful pregnancy.
Application(s):
The Fertility Profile is geared towards women
•who have irregular cycles or fertility issues
•who have been trying to get pregnant without
success, or
•who would like to be proactive in their preconception
planning by getting a baseline screening
Technique:
Enzyme Immunoassay (EIA)
Sample Type:
Saliva & Blood Spot
TAT:
5-10 Business Days
Sample Report:
http://www.easternbiotech.com/reports/FP.pdf
Feel as if the clock is ticking in you and unable to conceive?
Fertility profile can uncover underlying hormonal imbalances.
52
Cardio Metabolic Profile
Description:
Risk for Cardio Vascular Disease and Diabetes II
is known to be particularly high in people who
have a disorder known as “metabolic syndrome”,
which is often associated with being overweight.
CardioMetabolic Profile tests blood markers that can
identify people at high risk of these diseases. If levels
of several of these blood markers are abnormal, this
should be an important “wake-up call” to tackle the
problem. Biomarkers such as In, hsCRP, HbA1c, TG,
CH, HDL, LDL, VLDL) are used to asses risk factors for
the metabolic syndromes.
Application(s):
Test is used to Identify individuals at risk for
CardioMetabolic/Insulin resistance syndromes. It is
very likely that one can be diagnosed with metabolic
syndrome if any of the following conditions are
present:
•Obesity, especially in the waist/abdominal area (the
“apple-shaped” body type)
•A body mass index (BMI) greater than 25
•High blood pressure
•Insulin resistance and/or glucose intolerance (high
fasting blood glucose or high fasting insulin levels)
•An abnormal lipid profile known as “atherogenic
dyslipidemia” (low HDL cholesterol, high LDL
cholesterol, high VLDL cholesterol, high triglycerides)
•Inflammation
Insulin resistance, atherogenic dyslipidemia, and
inflammation are known as cardiometabolic risk
factors and can only be assessed by a blood test such
as the CardioMetabolic Profile.
Technique:
Multiple Immunological techniques
Sample Type:
Dried Blood Spot
TAT:
5-10 business days
Sample Report:
http://www.easternbiotech.com/reports/CMP.pdf
Simple lifestyle changes may improve overall risk for Cardio
Vascular Disease and Diabetes II. Identify the risks from a
simple blood spot test
53
Neurotransmitters
Description:
Testing neurotransmitters in patients with
psychological conditions can help target specific
imbalances – getting to the root of persistent issues
such as adrenal dysfunction, mood disorders, lack
of ambition and lack of appetite. Neurotransmitter
testing gives practitioners a diagnostic edge over
the traditional psychological inventory. It offers the
advantage of zeroing in on which therapies are best
suited for an individual patient. Combining
neurotransmitter testing with other hormone
testing gives practitioners an even deeper insight
into a patient’s Individual neurochemistry.
Application(s):
Patients who should be tested include those who
suffer from:
•Insomnia
•Depression
•Persistent fatigue
•Poor memory
•Anxiety
•Low libido
•Feeling perpetually drained
Technique:
Multiple Immunological techniques
Sample Type:
Dried Urine
TAT:
5-10 business days
Sample Report:
http://www.easternbiotech.com/reports/NTM.pdf
Suffering from psychological symptoms? Imbalances in
neurotransmitters can cause the brain & body to be over- or
under- stimulated that can lead to such symptoms!
54
Urine Hormones Metabolites
There are steps you can take if you are concerned about how
your body is processing hormones!
Description:
Test assesses both parent hormones and their
corresponding metabolites, it reveals how the body
is breaking down key hormones like estrogens,
progestogens, androgens, cortisol and melatonin.
This testing gives insight into whether we are fully
detoxifying our hormones, which is important
because some hormones can be carcinogenic if they
don’t break down properly – leaving us more at
risk for a variety of diseases, like cancer.
Application(s):
It a good idea to consider urinary hormone testing for
•At risk of hormone-dependent cancers – like breast
cancer or prostate cancer
•Showing normal saliva cortisol levels but still
experiencing symptoms of adrenal dysfunction
•Considering hormone replacement therapy
•Experiencing symptoms of cortisol imbalance
•Having symptoms of hormonal imbalance such as
weight gain and insomnia
Technique:
Chromatography/Mass Spectrometry
Sample Type:
Dried Urine
TAT:
5-10 business days
Sample Report:
http://www.easternbiotech.com/reports/UHM.pdf
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Metals Hair Test
Description:
Heavy metals toxicity caused by increasing levels of
pollution and use of chemicals in industry is a growing
threat to our health and development of our children.
High levels of toxic metals deposited in body tissues
and subsequently in the brain, may cause significant
developmental and neurological damage. A Metals
Hair Test is ideal for checking current exposure to
toxic metals. Hair provides important information
that can assist the practitioner with an early diagnosis
of physiological disorders associated with aberrations
in essential and toxic element metabolism.
Application(s):
Hair element analysis provides important information
which, in conjunction with symptoms and other
laboratory values, can assist the physician with an
early diagnosis of physiological disorders associated
with aberrations in essential and toxic element
metabolism.
•Determine if metal toxicity or mineral deficiency is
contributing to the disorder
•Monitor the effects of chelation (elimination of
heavy metals from the body)
•Identify if supplementation of important minerals
may bring about significant improvements
Technique:
Mass Spectrometry (ICP/MS)
Sample Type:
Hair
TAT:
2-3 weeks
Sample Report:
http://www.easternbiotech.com/reports/MHT.pdf
Toxic metals can affect development, neurological functioning,
and overall health
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7.
COUNSELING
SERVICES
Counseling is a collaborative process that involves the development of a confidential
professional relationship that focuses on personal problems. It is an opportunity to
talk to a licensed personnel who is a skilled listener trained in the appropriate field.
The objective of counseling is to help you clarify issues, gain insight into your feelings
and thoughts and deal with the problems effectively. The most helpful aspect of
counseling is that the counselor is objective and is not involved in the situation you’re
trying to resolve. The counselor has only your best interests to consider.
• Genetic Counseling
• Nutritional Consultation
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Genetic Counseling
Genetic tests are incomplete without appropriate advice and guidance. Genetic counselors need to frequently speak
to the clients about complex scientific and emotional issues.
The counseling involves –
•Confirming, diagnosing or ruling out a genetic condition.
•Management.
•Communicating genetic risk for future generation.
•Providing psychological support.
Our highly qualified genetic counselors offer pre and post test counseling either online, by telephone, or in person.
www.geneticcounseling.ae
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Nutritional Consultation
Nutritional consultation involves building a detailed picture of lifestyle, eating habits, medical history and any
concerns one may have about their health. Our nutritional consultant can work to form an eating plan that suits
client’s needs, their lifestyle and daily commitments. The consultant will help clients identify and avoid unnecessary
or harmful foods and enjoy an abundance of wonderful food that makes him feel good in body and in mind. The clients
will take away a tailor-made plan of action knowing exactly what they need to do next.
www.nutritionhelp.info
Predictive Preventive
Personalized
Diagnostics
Headquarter:
Eastern Biotech & Life Sciences
P.O.Box 212671, Elite Business Center
1st Floor # 109, Al-Barsha, Dubai, UAE.
+971 4 3255730 Free : 800-ECLABS
[email protected]
www.easternbiotech.com
Diagnostic Laboratory:
Eastern Clinical Laboratories
P.O.Box 212671, Elite Business Center
1st Floor # 105, Al-Barsha, Dubai, UAE.
+971 4 3244512
[email protected]
www.ecl.ae