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ADHD Etiology 8.4% of children Boys>Girls Deficit of catecholamines _____ & ______________________ Decreased threshold for stimuli (_________________) Delay in self-regulation (________________, ______________________) Clinical Manifestations DSM V Criteria Inattentive Hyperactivity for 6 months Impulsivity for 6 months Some symptoms present before age ___________ Present in 2 or more settings Impairment in social, academic or occupational functioning Not accounted by another Mental Illness Diagnosis Family history Birth history G&D milestones Sleeping & eating patterns School performance Social & environmental conditions PE-R/O neurological cause Social Implications Parents Children Co-morbidities Therapy Environmental Behavior Diet Medications Medications-Stimulants Increase synaptic levels of dopamine & norepinephrine 2-4 weeks to titrate dose for effect Long-acting Short-acting Chewable forms Reduces interrupting, fidgeting, (hyperactive sx) Improves task completion & home relationships Medications - Stimulants Adderall® (intermediateacting) Adderall XR® (long-acting) Concerta® (long-acting) Daytrana® (long-acting patch) Dexedrine® (short-acting) Dexedrine® Spansule® (intermediate-acting) Focalin® (short-acting) Focalin XR® (long-acting) Metadate CD® (longacting) Metadate® ER (intermediate-acting) Methylin™ ER (intermediate-acting) Ritalin® (short-acting) Ritalin LA® (long-acting) Ritalin SR® (intermediateacting) Vyvanse® (long-acting) Medications-Stimulants Adverse Effects _________________ _________________ Headaches Abdominal discomfort ___________________ Irritability ___________________ Social withdrawal Lowers seizure threshold Medications-Nonstimulants Norepinephrine reuptake inhibitor Anti-depressants atomoxetine (Strattera) - 1-2 X a day Less potential of substance abuse Risk for ______________ Biggest side effect – _____________________ Ideal for ADHD + depression not as effective as stimulants or Strattera at improving attention span and concentration. Tricyclic antidepressants: Pamelor™ (nortriptyline), Tofranil® (imipramine), and Norpramin® (desipramine) Wellbutrin, Effexor, Monoamine oxidase inhibitors (MAOIs) Alpha Adrenergic Agonists Extended-release meds - guanfacine (Intuniv) - clonidine (Kapvay) *used if no response to stimulants *used as adjunct for partial response to stimulants Future substance abuse According to the National Institute of Drug Abuse, the answer is no. "The studies conducted so far have found no differences in later substance use for children with ADHD who received treatment and those that did not. This suggests treatment with ADHD medication appears not to affect (either negatively or positively) an individual’s risk for developing a substance use disorder." (National Institute of Drug Abuse, 2014). Follow-up How often should we follow-up and why? https://youtu.be/z2hLa5kDRCA