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Disruptive selection, also called diversifying selection, is a descriptive term used to describe changes in population genetics that simultaneously favor individuals at both extremes of the distribution. When disruptive selection operates, individuals at the extremes contribute more offspring than those in the center, producing two peaks in the distribution of a particular trait. Disruptive selection is of particular significance in the history of evolutionary study, as it is involved in one of evolution's "cardinal cases", namely the finch populations observed by Darwin in the Galápagos. Directional selection occurs when natural selection favors a single phenotype and therefore allele frequency continuously shifts in one direction. Under directional selection, the advantageous allele will increase in frequency independently of its dominance relative to other alleles (i.e. even if the advantageous allele is recessive, it will eventually become fixed). Well-known instances are the many cases of insect resistance to pesticides, which are synthetic substances not present in the natural environment. When a new insecticide is first applied to control a pest, the results are encouraging because a small amount of the insecticide is sufficient to bring the pest organism under control. As time passes, however, the amount required to achieve a certain level of control must be increased again and again until finally it becomes ineffective or economically impractical. This occurs because organisms become resistant to the pesticide through directional selection.