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Lecture Questions/Key concepts to review -Selective Sweeps -Selection-Drift Balance – Wright’s model -Gene Flow vs Genetic Drift -Example of the coal mine -Molecular Clock Kirkpatrick 2013 Jeopardy Instructions • Break into groups. • Come up with team names. • Pull out a notebook or some paper to write your answers on. • Hold up the paper with the answer on it when you have finished (no need to answer with “what is...”, “who is...”, etc.) Evolution Human Diversity MATH Natural Selection and Migration Cultural Impact 10 10 10 10 10 20 20 20 20 20 30 30 30 30 30 40 40 40 40 40 50 50 50 50 50 Evolution – 10 Points QUESTION: Define “evolution” and its 4 major forces. ANSWER: Changes in allele frequencies over time within a population. (1) Natural Selection, (2) Genetic Drift, (3) Mutation, (4) Gene Flow aka Migration Evolution – 20 Points QUESTION: If population size increases the strength of genetic drift _______ while natural selection _________. ANSWER: If population size increases the strength of genetic drift decreases while natural selection increases. Evolution – 30 Points QUESTION: What statistic did Cavalli-Sforza examine in the Parma Valley between villages? Define this statistic. ANSWER: FST aka Wrights Fixation index, F statistic, Inbreeding coefficient. It is a measure of variability between populations. Evolution – 40 Points QUESTION: DAILY DOUBLE What “neutral” phenomenon does this graph show geographic distance and human skull variation? ANSWER: Isolation by distance Evolution – 50 Points QUESTION: Name the 3 most important scientific contributors to the “Modern Synthesis” aka when population geneticists integrated natural selection, Mendelian genetics, and micro and macroevolutionary ideas together to explain evolution. ANSWER: Sewall Wright, Ronald Fisher, JBS Haldane Human Diversity – 10 Points QUESTION: What is the name of the model that describes human evolution as a result of migration from a source population being repeated with each new resulting population eventually leading to a major loss of genetic diversity? ANSWER: Serial Founder Human Diversity – 20 Points QUESTION: All non-African human populations are thought to share a common ancestor ______ years ago. ANSWER: 60,000 to 70,000 Human Diversity – 30 Points QUESTION: All Native Americans share __ mitochondrial haplotypes and __ Y haplotypes. This is part of a larger __________ found in Siberia. ANSWER: All Native Americans share 5 mitochondrial haplotypes and 2 Y haplotypes. This is part of a larger haplogroup found in Siberia. Human Diversity – 40 Points QUESTION: What type of selection is evident from increased malaria resistance in Africa for heterozygotes of the sickle cell allele? ANSWER: Frequency Dependent Selection (this is also a case of overdominance or heterozygote advantage) Human Diversity – 50 Points QUESTION: Name 2 candidate genes examined in the research study about human pigmentation and selection. ANSWER: –TYR, tyrosinase is an enzyme makes early forms of pigment –MATP helps traffic this enzyme to right part of melanocyte (melanosomes) –OCA2 is an ion transporter on the surface of melanosomes, and helps maintain their pH –SLC24A5 , Ca2+ transporter that regulates melanosome function –MC1R, receptor that triggers deposition of dark eumelanin –ASIP, agouti-signaling peptide, is a natural antgonist to MC1R and blocks effects of MSH MATH – 10 Points QUESTION: What is the mathematical equation for broad sense heritability? What do the variables mean? ANSWER: H2 = VG /VP Genetic variation / phenotypic variation MATH – 20 Points QUESTION: If there are 15 p alleles and 25 q alleles in a population of 20, what is the frequency of q? What’s the expected Heterozygosity? ANSWER: q = 25/40 = 0.625 2pq = 0.46 MATH – 30 Points QUESTION: What simple equation allows you to detect natural selection from genetic data? What do the variables stand for? ANSWER: dN/dS Nonsynonymous / synonymous mutations MATH – 40 Points QUESTION: DAILY DOUBLE The number of new alleles within a population can be determined by what equation and variables? ANSWER: # new alleles = µ * Ne * # generations MATH – 50 Points QUESTION: What is the equation for genetic variance? Define the variables. ANSWER: Vg = Va + Vd + Vei Va : additive variance Vd : dominance variance Vei : epigenetic variance Natural Selection – 10 Points QUESTION: What type of selection is show by the second graph? ANSWER: Disruptive Natural Selection – 20 Points QUESTION: What evolutionary forces leave behind a pattern on the entire genome? ANSWER: Neutral forces like drift and gene flow happen on the whole genome, while selection acts only on those genes that contribute to a phenotype. Human Migration – 30 Points QUESTION: Briefly, describe the experiment to detect who was first to admix with the Rapanui people in Moreno-Mayar et al paper. ANSWER: (1) ADMIXTURE analysis at K=4 to find the native american and European Component (2) Analyze the size of the tracts of ancestry. (3) Use a fancy likelihood-model to determine the time to admixture. Natural Selection – 40 Points QUESTION: What do you call the phenomenon of a new mutation increasing rapidly in frequency and dragging along nearby variants with it? Name 1 piece of genetic evidence supporting this phenomenon. ANSWER: Selective Sweep (1) Low variation near selected sequence. (2) Long common haplotypes surrounding selected sequence. Natural Selection – 50 Points QUESTION: What is the major assumption or generalization we make in regards to mutations? ANSWER: That they normally are either neutral or very weakly deleterious. Cultural Impact – 10 Points QUESTION: When and where do we think agriculture emerged first? ANSWER: About 11,000 years ago in the Fertile Crescent. Cultural Impact – 20 Points QUESTION: What two groups of humans lack independently evolved genes that protect against diabetes putting them at greater risk of disease from a carbohydrate right diet? ANSWER: Amerindians and Australian Aborigines Cultural Impact – 30 Points QUESTION: What do you call the genetic modifier regulating lactase persistence? What type of evolution is lactase persistence an example of? ANSWER: A non-coding enhancer; convergent evolution Cultural Impact – 40 Points QUESTION: Agriculture was invented independently by what groups? What crops did they create? ANSWER: Middle Easterners: wheat, barley, lentils, peas Sub-Saharan Africans: yams & sorghum Amerindians: potatoes & corn Cultural Impact – 50 Points QUESTION: What was the average decrease in height associated with the shift to agriculture? ANSWER: 5 inches