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Posters –
Devices and Imaging
NAME OF THE PROJECT
NAME OF THE MAIN CONTACT
ORGANISATION NAME
DIABETACHIP : A new device for real-time analysis of pancreatic β-cells and islets
JEAN-LUC CHAGNAUD
AQUITAINE SCIENCE TRANSFERT
The amount of insulin required by a human body is not only set by glucose but also by
other nutrients as well as by hormones, the latter reflect the physiological state of the
body. Shaped by evolution, β-cells constitute the most sophisticated tool for determining
insulin requirements. The β-cells express their electrical activity not only according to the
level of glucose, but also to various other nutrients and hormones.
Technology
The electrical activity of β-cells is characterized by action potentials (AP), representative
of single cells, and by slow potentials (SP), reflecting the degree of physiological coupling
between islet cells.
Combining technologies from microelectronics and biology, the Diabetachip system is
able to evaluate in real time the performance of islets prior to transplantation, the
properties of stem-cell derived islet surrogates or the effects of molecules on islet
function.
Islets quality control for transplantation:
Diabetachip technology value: Portable device for fast quality control in clinical
laboratories
On-line monitoring of stem cells differentiation into βcells:
Diabetachip technology value:
 Diaβchip is able to monitor their development on a noninvasive natural base without
additional reporter genes and provides a useful element in quality control.
 Cell response assessment based on real-time measurements for single cell
characteristics (AP) and the capacity of physiological cell-to-cell coupling (SP)
Customers / Target market
Drug discovery:
Diabetachip technology value:
 Test the effect of candidate drugs on β-cells
 Evaluate single cell and physiological relevant coupling in islet cells or within whole
islets.
 Non-invasive recording of the electrical activity and its analysis in real time provides
the possibility of long-term and repetitive investigations or testing of multiple drugs.
 Research phase: Functional Analysis -> More precise measurement of the effects of
drug candidates - In clinical phase II (Subjects patients): In Vitro Measurement of the
therapeutic efficacy of a molecule on human cells
Industry and competitors
Financing need / Commercial
opportunity
IP – Patent situation
N/A
CODEVELOPMENT AND/OR LICENSING OUT
A patent application was filed in January 2010. The invention relates to:
 a sensor including: a microelectrode array and β-pancreatic cells or islets of
Langerhans in culture on the microelectrode array. The microelectrode array is
designed to measure dynamically, continuously and in real time, electrical
signals produced by the pancreatic β-cells or the islets of Langerhans upon
physiological activation.
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the sensor can be used on its own to characterize rapidly islet preparations or
provide read-outs for drug tests
devices that can be implantable in the body of a patient, and including an insulin
pump for dispensing a given amount of insulin.
a method for manufacturing such a sensor and a device and a use of such a
sensor.
the associated applications.
This patent application is currently under examination in several countries including
Europe, US, Japan, China, Mexico, South Korea, India, Brazil, Australia and Canada.
Future steps / Milestones
TRL : technology validated in lab
Further reading
N/A
Contact person
Jean-Luc CHAGNAUD, Healthcare Business Development Manager, AQUITAINE SCIENCE
TRANSFERT
[email protected]
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