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MEREDITH A. SAUNDERS Curriculum Vitae September 2016 University of Kentucky, Department of Psychology BBSRB, rm. B0448D 741 S. Limestone St. Lexington, Kentucky, 40536-0509 Phone: 502.323.0575 email. [email protected] EDUCATION 2016 M.S., Department of Psychology, University of Kentucky 2016 Biostatistics Certificate (in progress), University of Kentucky 2013 B.S., Department of Psychology, University of Kentucky Psychology Department Honors Magna Cum Laude RESEARCH EXPERIENCE 2013–present Neuropharmacology of drugs of abuse in vitro and in vivo (Dr. Mark Prendergast), University of Kentucky, Spinal Cord and Brain Injury Research Center, Department of Psychology, Lexington, Kentucky 2012–2013 Effects of ethanol and corticosterone on hippocampal cell death in vitro (Undergraduate senior research project supervised under Dr. Mark Prendergast), University of Kentucky, Spinal Cord and Brain Injury Research Center, Department of Psychology, Lexington, Kentucky 2012 Effects of parental problem drinking on child physiological responses (Undergraduate research supervised under Dr. Peggy Keller), Laboratory of Development and Family Stress, Department of Psychology, Lexington, Kentucky FELLOWSHIPS AND AWARDS 2016 Pre-doctoral Trainee: National Institute on Drug Abuse (NIDA) T32–DA16176, University of Kentucky (Dr. Linda Dwoskin) 2016 Lipman Summer Research Award in Alcohol Dependence, Department of Psychology, University of Kentucky (Dr. Mark Prendergast) PUBLICATIONS Reynolds, A.R., Saunders, M.A., & Prendergast, M.A. (2016). Ethanol stimulates endoplasmic reticulum inositol triphosphate and sigma receptors to promote withdrawal- associated loss of neuron specific nuclear protein/Fox-3. Alcoholism: Clinical and Experimental Research, 40(7), 1454-61. Berry, J.N., Saunders, M.A., Sharrett-Field, L.J, Reynolds, A.R., Bardo, M.T., Pauly, J.R., & Prendergast, M.A. (2016). Corticosterone enhances N-methyl-D-aspartate receptor signaling to promote ventral tegmental area neurotoxicity in the reconstituted mesolimbic dopamine pathway. Brain Research Bulletin, 120, 159–165. Reynolds, A.R., Williams, L.A., Saunders, M.A., & Prendergast, M.A. (2015). Group 1 mGlufamily proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage. Drug and Alcohol Dependence, 156, 213–220. Reynolds, A.R., Saunders, M.A., Brewton, H.W., Winchester, S.R., Elgumati, I.E., & Prendergast, M.A. (2015). Acute oral administration of the novel, competitive and selective glucocorticoid receptor antagonist ORG 34517 reduces the severity of ethanol withdrawal and related hypothalamic- pituitary-adrenal axis activation. Drug and Alcohol Dependence, 154, 100–104. Wang, X., Reynolds, A.R., Elshahawi, S.I., Shaaban, K.A., Ponomareva, L.V., Saunders, M.A., Elgumati, I.E., Zhang, Y., Copley, G.C., Hower, J.C., Sunkara, M., Morris, A.J., Kharel, M.K., Van Lanen, S.G., Prendergast, M.A., Thorson, J.S. (2015). Terfestatins B and C, new p-terphenyl glycosides produced by streptomyces sp. RM-5–8. Organics Letters, 17(11), 2796–9. SUBMITTED MANUSCRIPTS Shaaban, K.A., Saunders, M.A., Zhang, Y., Tran, T., Elshahawi, S.I., Ponomareva, L.V., Wang, X., Zhang, J., Copley, G.C., Sunkara, M., Kharel, M.K., Morris, A.J., Hower, J.C., Tremblay, M.S., Prendergast, M.A., & Thorson, J.S. Spoxazomicin D and Oxachelin C, potent neuroprotective carboxamides from the Appalachian coal fireassociated isolate Streptomyces sp. RM-14-6 (Submitted to Journal of Natural Products). Zhang, J., Hughes, R.R., Saunders, M.A., Elshahawi, S.I., Ponomareva, L.V., Zhang, Y., Winchester, S.R., Scott, S.A., Sunkara, M., Morris, A.J., Prendergast, M.A., Shaaban, K.A., & Thorson, J.S. Microbial natural product glycosyl-scanning as an enabling platform for neuroprotective spoxazomicin and oxachelin glycoside discovery (Submitted to Journal of Natural Products). Reynolds A.R., Berry, J.N., Sharrett-Field, L.J., Saunders, M.A., & Prendergast, M.A. Broadspectrum protein kinase inhibition by the staurosporine analog KT-5720 reverses ethanol withdrawal-associated loss of NeuN/Fox-3. MANUSCRIPTS IN PREPARATION Saunders, M.A. & Prenderdast, M.A. Effects of cysteine protease inhibition on hippocampal neurotoxicity in vitro. Saunders, M.A., & Prendergast, M.A. Ethanol promotes isolated ventral tegmental area toxicity in a reconstituted mesolimbic dopamine pathway. Shaaban, K.A., Saunders, M.A., Zhang, Y., Tran, T., Elshahawi, S.I., Ponomareva, L.V., Wang, X., Copley, G.C., Sunkara, M., Kharel, M.K., Morris, A.J., Hower, J.C., Tremblay, M.S., Prendergast, M.A., and Thorson, J.S. Spoxazomicin D, a Potent Neuroprotective Oxazole Carboxamide, and Oxachelin Analogues from an Appalachian isolate Streptomyces sp. RM-14-6. Zhang, J., Saunders, M.A., Hughes, R.R., Shaaban, K.A., Elshahawi, S.I., Ponomareva, L.V., Zhang, Y., Sunkara, M., Morris, A.J., Winchester, S.R., Scott, S.A., Prendergast, M.A., and Thorson, J.S. The impact of spoxazomicin glucosylation upon neuroprotective activity. Berry, J.N., Butler, T.R., Sharrett-Field, L.J., Reynolds, A.R., Saunders, M.A., & Prendergast, M.A. Exposure to corticosterone during ethanol exposure and withdrawal augments the loss of synaptophysin immunoreactivity in a GluN2B-dependent manner. Sharrett-Field, L.J., Saunders, M.A., Reynolds A.R., Berry J.N., Williams, L., Prendergast, M.A. Plasma corticosterone levels are correlated with subsequent voluntary intake of ethanol using a chronic, intermittent access paradigm. Reynolds A.R., Williams, L.A., Sharrett-Field, L.J., Saunders, M.A., & Prendergast, M.A. Sigma-1 receptor activation promotes age-related loss of neuron specific nuclear protein in vitro. Prendergast, M.A., Butler, T.R., Smith, K.J., Reynolds, A.R., Saunders, M.A., Little, H.J. The novel, competitive glucocorticoid receptor antagonist PT 150 reduces the severity of withdrawal from repeated binge-like ethanol administration. CONFERENCE PRESENTATIONS Saunders, M.A., Maggio, S.E., Shaaban, K.A., Zhang, Y., Zhang, J., Watt, D., Frasinyuk, M., Yuan, Y., Zhan, C.-G., Nixon, K., Thorson, J.S., Bardo, M.T., & Prendergast, M.A. (Sept. 2016). Novel synthetic isoflavonoid for the treatment of alcohol and nicotine co-use. Abstract submitted for poster presentation, 2016 Clinical-Translational Research Symposium, Lexington, Kentucky. Saunders, M.A., Shaaban, K.A., Zhang, Y., Zhang, J., Thorson, J.S., Yuan, Y., Zhan, C.-G., Nixon, K., & Prendergast, M.A. (June, 2016). Novel spoxazomixicins derived from Streptomyces sp. RM-14−6 attenuate ethanol induced cytotoxicity in vitro. Abstract submitted for poster presentation, Research Society on Alcoholism, New Orleans, Louisiana. Saunders, M.A., Maggio, S.E., Shaaban, K.A., Zhang, Y., Zhang, J., Watt, D., Frasinyuk, M., Yuan, Y., Zhan, C.-G., Nixon, K., Thorson, J.S., Bardo, M.T., & Prendergast, M.A. (April, 2016). Novel synthetic isoflavone for the treatment of AUD: An examination in vitro and in vivo. Abstract submitted for poster presentation, 32nd Annual BGSFN Spring Neuroscience Day, Lexington, Kentucky. *Received Outstanding Graduate Student Poster Award Saunders, M.A., Maggio, S.E., Van Skike, C.E., Shaaban, K.A., Zhang, Y., Zhang, J., Thorson, J.S., Yuan, Y., Zhan, C.-G., Dwoskin, L.P., Prendergast, M.A., Bardo, M., & Nixon, K. (2015). Novel natural products derived from Streptomyces sp. RM-14–6 for the treatment of alcohol and nicotine co-dependence. Abstract submitted for poster presentation, Symposium on Drug Discovery & Development, Lexington, Kentucky. *Received 2nd Place Outstanding Poster Presentation Award Saunders, M.A., Maggio, S.E., Van Skike, C.E., Zhang, Y., Shaaban, K.A., Zhang, J., Thorson, J.S., Yuan, Y., Zhan, C.-G., Dwoskin, L.P., Prendergast, M.A., Bardo, M., & Nixon, K. (2015). Screening CPRI repository for treating alcohol and nicotine codependence. Abstract submitted for poster presentation, 4th Annual-University of Kentucky Natural Products Consortium Symposium, Lexington, Kentucky. Reynolds, A.R., Berry, J.N., Sharrett-Field, L.J., Saunders, M.A., & Prendergast, M.A. (2014). Ethanol exposure stimulates the mGluR5 receptor prior to withdrawal to promote cytotoxicity of chronic, intermittent ethanol. Abstract submitted for poster presentation, Research Society on Alcoholism, Bellevue, Washington. Saunders, M.A. & Prendergast, M.A. (2013). Co-exposure to corticosterone and ethanol causes increased neurotoxicity: An examination in vitro. University of Kentucky Honors Day, Department of Psychology, Lexington, Kentucky. TEACHING EXPERIENCE 2016 Co-Instructure: Psychopharmacology 2016 Teaching Assistant: Experimental Psychology 2014-2016 Grader: Psychopharmacology 2015 Grader: Brain and Behavior 2014–2015 Teaching Assistant: Brain and Behavior 2014–2015 Teaching Assistant: Introduction to Statistics 2013 Teaching Assistant: Introduction to Psychology LEADERSHIP AND UNIVERSITY SERVICE 2013-present Student Research Mentor, Summer Training in Alcohol Research, University of Kentucky; Undergraduate Student Research Mentor for Psychology and Biology Majors, University of Kentucky 2000-present PATH Coalition of Nelson County (focused on informing members of the community, especially youth, on the risks of drug use and abuse), Bardstown, KY PROFESSIONAL AFFILIATIONS 2015-present Research Society on Alcoholism 2013–present Bluegrass Chapter of Society for Neuroscience 2015–present Society for Neuroscience 2015–present Psi Chi