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Download Chlamydia pneumoniae
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J. Anderson F2013 Modified by DYH Chlamydia pneumoniae • Obligate Intracellular bacterium • Causes respiratory infections including acute pneumonia, bronchitis, sinusitis and pharyngitis. • Occupies intracellular niche, which makes it able to survive & multiply • Gram-negative bacteria • Exists as Elementary Body (EB) between hosts www.cpnhelp.org/publicimages/EBsOnRBCs.jpg J. Anderson F2013 Modified by DYH Chlamydia pneumoniae • Refractory to antibiotic treatment and is associated with chronic infection, as well as atherosclerotic process linkage. • Includes a replicative and non-replicative genetic state of the pathogen. • Can infect numerous types of cells (eg. Vascular endothelial cells and smooth muscle cells, alveolar epithelial cells, fibroblasts, mononuclear cells, T-cells and dendritic cells, neuronal glia cells) • Inhibits host cell lysis. • Uses the type III secretion (T3S) apparatus for infection. http://www.cpnhelp.org/images/graphic22.png
