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Shigella dysenteriae N. Mitchell F2013 Modified by DYH • • • • • Gram negative rods Enterbacteriaciae. Facultative anaerobe Non-motile, non-lactose fermenting Causes inflammatory disorder of the intestine (dysentery). – can lead to watery and bloody diarrhea, can also cause abdominal pain • Dysentery results in the destruction of the epithelial cells of the intestinal mucosa. • Contains the endotoxin Shiga toxin • Major cause of diarrheal disease in developing nations http://www.novasep.com/biomolecules/Biopharma/Applications/ Live-Vaccines.asp http://www.shigellablog.com/shigella-information/bad-bug-bookfoodborne-pathogenic-microorganisms-and-natural-toxins-second-editionshigella-species/#.UoFqKM09ykQ Shigella dysenteriae • Pathogenic • Penetrates through the mucosal lining of the colon • Shigella is able to penetrate the vacuole and replicate in the cytoplasm and uses M cell foreign transportation • Actin filaments move bacteria through the cytoplasm • Produces the endotoxin Shiga toxin N. Mitchell F2013 Modified by DYH http://www.nature.com/ni/journal/v8/n1/fig_tab/ni0107-15_F1.html – It is a neurtoxin, cytotoxic, entertoxin – Adheres to small intestine, blocks absorption of nutrients – Inhibits protein synthesis – Causes fever and abdominal cramping http://trialx.com/curebyte/2012/10/28/what-does-shigella-infection-look-like/ http://www.life.umd.edu/classroom/bsci424/pathogendescriptions/Shigella.htm
