Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
A. Cravens F2013 Modified by DYH Gram positive, rod-shaped, spore forming obligate anaerobe, found primarily in soil and less commonly in human and animal fecal material. Causative agent of tetanus(4 clinical types). Spores enter the body via open wounds and germinate in the ananoxic dead tissue to spread its virulence factors. 30% fatality rate. Disease characterized by severe and painful muscle contractions strong enough to cause fractures and muscle tears. Vaccine and antitoxin available. http://www.anatomyacts.co.uk/exhibition/object.asp?objectnum=62 http://www.corbisimages.com/stock-photo/rights-managed/42-18705359/clostridium-tetani-bacteria A. Cravens F2013 Modified by DYH Virulence factors -Tetanolysin: endotoxin that damages the tissue surrounding an infection, in order to optimize conditions in the wound. http://www.docstoc.com/docs/123452532/clostridium-tetni http://en.wikipedia.org/wiki/File:Diagram_of_structure_of_tetanospasmin.gif#globalusage Tetanospasmin toxin: Actual causative agent of tetanus released by bacteria growing in the wound site. Endotoxin that blocks postsynaptic inhibition of spinal motor reflexes leading to spastic contraction of muscles (tetany). Tetanospasmin toxin is mainly released during stationary phase of growth.The majority of the toxins are released once the cell lyses to spread throughout the host.