Download Mycobacterium tuberculosis

J. Rai F2013.
Modified by DYH
Mycobacterium tuberculosis
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This microbe is an Actinobacteria.
Actinobacteria are soil liking microbes and are gram positive and contain a thick
peptidoglycan layer.
They also depend on aerobic respiration.
They are rod shaped, and do not move on their own.
They have been known to cause Leprosy and Tuberculosis.
They are normally found in the human.
They normally infect a host through the respiratory system by inhalation.
The ability of Mycobacterium tuberculosis to infect a host depends much on the
hosts innate immunity.
J. Rai F2013.
Modified by DYH
Virulence Factors
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Are they are able to effectively clear the microbe?
The ability of mannose binding lectin to bind to the microbe affects the ability of
the host to activate T cells to mediate an immune response. Some strains of M.
tuberculosis are more virulent than others.
The virulence is dependent on chord factors, which refers to the ability to grow in
a serpent like shape.
Factors to avoid the immune system
They are able to detoxify oxygen radicals making lysosymes and peroxysomes not
as effective in macrophages.
Highly resistant cell walls and a slow generation time
They can grow within cells
They have many different proteins for growth factors and adhesion factors to the
host.
They have an ability to affect class switching of IgG1 to IgG2 during an immune
response once the infection has taken place.