Download 1-Ethyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3

Publications:
A) Published papers;
 Synthesis and studying of antituberculosis properties 2-fluorineanilides 1-R-2-oxo4-hydroxyquinolie-3-carboxylic acids. I.V.Ukrainets. Abdel Naser Dakkah, S.G.
Taran, O.V. Gorohova, L.V. Sidorenko. (Physiologically effective substance) 2000.
Pg.18-21.
Abstract:
Studied two appended receipt and the synthesis of 2-fluorineanilides1-R-2-oxo-4hydroxyquinoline-3-carboxylic acids, whose structure is confirmed by spectroscopy NMR.
Microbiology screening revealed that certain synthesized compounds have high
antituberculosis activity.

Synthesis antituberculosis activity of 3', 4'-fluorineanilides 1-R-2-oxo-4hydroxyquinolie-3-carboxylic acids. . I.V.Ukrainets. Abdel Naser Dakkah, S.G.
Taran, P.O. Bezugly, O.V. Gorohova, L.V. Sidorenko. (The bulletin of pharmacy.2001. Pg. 9-12.
Abstract:
To reveal the regularities of "structure – antituberculosis action" relationship the 3', 4'fluorineanilides1-R-2-oxo-4-hydroxyquinoline-3-carboxylic acids has been carried out.
The comparative analysis of biological properties of monofluoro substituted anilides of
3',4'-fluorineanilides1-R-2-oxo-4-hydroxyquinoline-3-carboxylic
acids
has
been performed. At allowed to reveal the most active fragments to antituberculosis
activity in their structure.

Synthesis and biological properties of 3', 4'-difluorineanilides 1-R-2-oxo-4hydroxyquinolie-3-carboxylic acids. I.V.Ukrainets. Abdel Naser Dakkah, S.G.
Taran, P.O. Bezugly, O.V. Gorohova. (Pharmacon-2002. Pg.71-74.
Abstract:
A possibility of N,N'-carbonyldiimidazole use in the synthesis of 3', 4'diflurorineanilides of 1-R-2-oxo-4-hydroxyquinolie-3-carboxylic acids has been studied.
Their structure is confirmed by NMR spectroscopy and counter synthesis. The results of
the antituberculosis activity of the compounds obtained study have been given.

1-Ethyl- 4-hydroxy-2-oxo-1, 2-dihydroquinoline-3-carboxylic acid. I.V.Ukrainets.
Abdel Naser Dakkah. S.V.Shishkina, O.V.Shishkin, (Acta Crystallographic Section
E-2002- Vol.58 Pg.254-256.
Abstract:
An X-ray diffraction study of the title compound, C12H11NO4, has shown that this
compound exists in the crystal as the 2-oxo-4-hydroxy tautomer. The formation of
two O-H O=C-type intermolecular hydrogen bonds leads to the elongation of both
exocyclic and carboxylic C=O double bonds involved in the hydrogen bonding,
causes shortening of the exocyclic C-O single bond, and also affects the C-C bond
lengths in the dihydropyridine ring.

4-Hydroxy-2-quinolines. 193. Synthesis, Structure and antitubercular activity of 4hydroxy-1-isobutyl-2-oxo-1, 2, 5, 6, 7, 8-hexahydroquinoline-3-carbocylic acid N-Ramides. (Chemistry of Heterocyclic Compounds 2010).
Abstract:
For example of anilides and hetarylamides 4-1-isobutyl-2-oxo-1, 2, 5, 6, 7, 8hexahydroquinoline-3-carbocylic acids showed that antituberecular properties of the
compounds of this kind of significant impact has substituent at the nitrogen atom of
quinoline. The features oh the spatial structure of the synthesized compounds, as well as
the results oh the study of their antimicrobial activity against Mycobacterium
tuberculosis H37Rv.
(Accepted for Publication in the Chemistry of Heterocyclic Compounds 2010)
B) PODIUM IN CONFERENCES:

Synthesis and antituberculosis properties of 2'-fluorineanilides 1-R-2-oxo-4hydroxyquinolie-3-carboxylic acids. The International conference (Chemistry Of
heterocycles –Containing nitrogen), 2-5 October 2000.Kharkive, Pg.238.

Studying of laws of communication (connection) "structure- ant tuberculosis
action" in number fluorine replaced anilides 1-R-2-oxo-4- hydroxyquinolie-3carboxylic acids."This thesis has been reported in a scientific and practical
conference (Scientists of Ukraine to national pharmacy) 2000. Kharkive. Pg.5-6.

Studying of a structure of 1-ethyl-2-Oxo-4-hydroxyquinoline-3-Carboxylic acid.
Ukrainian conference in organic chemistry, thesis addition, 11-14 September
2001.Lvov, Pg128.