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DR.M. ZAFAR QURESHI INTRODUCTION Cardiovascular system comprises of Heart Arteries Veins Capillaries INTRODUCTION Heart is a muscular organ & functions as a pump. Works in conjunction with lungs & vascular system Functionally two hearts & one lung Blood from venous system Rt side of heart to lungs via pulm. trunk back to Lt side of heart via pulm. veins To the entire body via aorta back to venous system LOCATION Middle mediastinum 1/3 lies on the rt & 2/3 on the left of median point of sternum. Second to fifth rib Skeleton of the heart It is formed by fibrous rings around the valves It gives origin to the whorls of the cardiac muscle It keeps the heart valves in an un collapsible state It acts as an insulator for the spread of electrical stimulus b/w atria & ventricles FEATURES OF HEART Conical Hollows organs. Situated in the middle mediastinum enclosed with in pericardium. Placed obliquely behind the body of sternum and adjoining part of costal cartilages. 1/3 of heart lies to the right and 2/3 to the left of median plane of sternum. Heart Measures about 12x9 cm or 5x3 inches (volume/ circumference) and weight about 300g in males and 250g in females. 4 chambers 4 Borders 2 atria 2 ventricles Upper border Lower or inferior Right border Left border Formed by border formed formed by formed by 2 atria mainly by right right artium. Mainly Left Left. Ventricle. ventricle & partly left aricle. Circulation of blood through heart 4 SURFACES Anterior Inferior surface Posterior surface left surface surface (Base) formed by Right atrium left ventricle & left atrium fommed by left atrium & Rt ventricle). & small part of Rt atrium . (left Ventricle) AN APEX (LEFT VENTRICLE) ( In 5 intercostal space just inner to mid-clavicular line ) th 3 GROOVS OR SULCI Atrio ventrienlar (coronary) Inter atrial groove. Inter ventricular groove. ATRIO VENTRICULAR GROOVE CIRCULAR SULCUS WHICH LODGES. Coronary Sinus. Small Cardiac vein. Coronary arteries. It obliterated interiorly by ascending aorta and pulmonary trunk. INTER ATRIAL GROOVE:Faintly visible posteriorly while anteriorly it is hidden by the aorta and pulmonary trunk. ANTERIOR INTER VENTRICULAR GROOVE: Near to the left margin of the heart. It contain anterior inter ventricular branch of the left coronary artery and great cardiac vein. Lower end of groove separates apex from rest of the inferior border of the heart. POSTERIOR INTER VENTRICULAR:- (i) Is situated on the diaphragmatic (inferior) surface of the heart. (ii) It lodges posterior inter ventricular branch of the right coronary artery and middle cardiac vein. (iii) Two (post & ant) inter ventricular grooves meet at the inferior border near the apex, the incisura apices cordis. FEATURES OF RT ARTIUM: From Rt border, Sternocostal surface & part of base of heart. Elongated chamber. Receiving sup & I.V.C. Interior is sponge like & prevent free flow of blood and favours thrombosis. These thrombi when disloged during auricular fibrillation cause pulmonary embolism. Suleus terminalis is a shallow vertical groove along right border b/w sup & I.V.C. It is produced by an internal muscular ridge called crista terminalis. The upper part of suleus termanalis contains (SA) sinoatrial node which act as the pace makes of the heart. Left atrium lies behind the right atrium. TRIBUTARIES (INLETS) OF RT ARTIUM:(i) (ii) (iii) (iv) (v) (vi) S.V.C. ( gaurded eustachian valve) rudimentry. I.V.C. ( Gaurded eustachian valve) rudimentry. Coronary sinus ( Gaurded by Thebasian valve) Anterior cardiac veins. Venae cordis minimi( Thebasian vessels) Some time Rt marginal veins. OUT LETS OF RT ARTIUM:(i) Tricuspid valve. (ii) Venae cordis mininmae (numerous mall pits in all 4 chambers more on right sides to ensure blood supply i.e why M.I. more common on left side.) Interior of right atrium is DIVIDED INTO 2 PARTS (A) Smooth posterior Part (sinous venarum) Rough anterior part or Pectinate or Auricle (A)SMOOTH PART (POSTERIOR) OR SINUS VENARUM Derived from right horn of sinus venosus Coronary sinus opens b/w I.V.C. and right atrioventricular openings & guarded by valve of coronary sinus (Thebasian valve). Venae cordis minimae are numerous small pits, in all four chambers & opens through foramina venarum minimarum. These are more numerous on right side ensuring better blood supply to the myocardium than that on left side that is why M.I. is more common on left side than right. Intervenous tubercle of lower is a very small projection, visible on the posterior wall of Rt atrium just blow the opening of S.V.C. During embryonic life it directs the superior caval blood to the right ventricle (B)ROUGH ANTERIOR PART PECTINATE PART (AURICLE) Devlopmentally derived from Primitive atrial chamber. It presents a series of transverse muscular ridges called musculi pectinati. They raise from crista teaminalis and run forward and downward towards the atrioventricular orifice, giving appearance of teeth of comb. Muscles in auricle are interconnected to form reticular network. Septal wall From the centeral part of posterior wall. Developmentally derived from septum primum and septum secondum. Present fossa ovalis, a shallow saucer – shaped depression, in the lower part, formed by septum primum. RIGHT VENTRICLE (triangular chamber) It form inferior border & large part of sernocostal surface and a small part of the diaphragmatic surface of heart. It receives blood from right atrium and pumps it to the lungs. Externally has two surface Anterior (sternocostal ) Inferior (diaphragmatic) Interior has 2 parts Inflowing part is rough due to musclular ridges called trabeculae carnae develop from primitive ventricle heart tube. Outflowing part or infundibulnm is smooth and form the upper one inch conical part of right ventricle which gives rise pulmonary trunk ( develops from the bulbs cordis). MUSCLAR PART of Rt ventricle TRAECULEA CARNAE Muscular ridges Fixed elevation (muscular ridges) Bridges c’ 2 ends Fixed & free at Centre Pillar (papillary muscles) one end connected to ventricle wall &other c’cusps of Tricvsprid valve by chordae tendinae Septomarginal trabecula (musclar ridges) contains right branch of bundle of his & prevents over distension of right ventricle. Right ventricle is (cresent) shaped due to bulging of interventricular septum. Wall of right ventricle is thinner than left ventricle Ratio 1:3 Left atrium (feature) Quadrangular chamber. Situated posteriorly Interiorly overlaped by right auricle. FORMS 2/3 OF BASE OF HEART GREATER PART OF UPPER BORDER STERNOCOSTAL & LEFT SURFACE PART OF LEFT BORDER OF HEART LEFT ATRIUM Posterior surface from anterior wall of oblique sinus of pericardium. Anterior wall from the interatrial septum. 2 pulmonary veins open on each side of posterior wall. Greater part is smooth wall derived from the absorption of pulmonary veins which open into it. Muscli pectinati (muscular part (rough ) present only in the auricle. Septal wall shows fossa lunata correspond to fossa ovalis of left atrium TRIBUTARIES 4 pulmary veins Venal cordis minimi Left ventricle ( features ) Receives qxygenated blood from left atrium. From apex of heart. Externally forms (3 surfaces) Anterior part form left surface forms most of left Sternocostal border inferior surface forms 2/3 of left diaphragmatic surface of heart Interior of left ventricle -Lower rough part with -upper smooth part (aortic vestibule) Trabeculae corae, Develops which gives origin to ascending aorta, From primitive ventricle of develops from bulbus cordis. Heart tube. -Vistibule lies between membranous part of the inter ventricuar septum and anterior (aortic) cusps of mitral valve. 2 orifices Left A.V orifice (bicuspid) aortic orifice (guarded by Mitral valve aortic valve) (tricuspid) 2 papillary muscles Ant post Both attached to cusps of mitral valve by chordae tendinae -Wall of left ventricle is 3 time thicker then those of right ventricle. Blood supply of heart Supplied by 2 coronary arteries arises from ascending aorta Right coronary artery -smaller than left -origin=Int aortic sinus left coronary -larger than right -origin=post aortic sinus BLOOD SUPPLY OF HEART Right coronary branches Large branches 1-Marginal 2- Posterior interventricular small branches 1-Nodal in 60% 2-Right Atrial 3-Infundibular 4-Terminal Left coronary branches Large branches 1-Anterior ventricular 2-Diaphragmatic branches to Left venricle small branches 1-Left atrial 2-pulmonary branches 3-Terminal branches Course Right C.A (course) It passes forward & to the right to emerge b/w the root of pulmonary trunk and right auricle. 2ndit runs downwards in the right anterior cornerary sulcus to the junction of the right and inferior border of heart Next it winds round and continuous in the posterior coronary sulcus upto the posterior interventicular groove. On entering the left coronary sulcus it terminates by anastomosing with the left coronary artery. Left C.A. (course) It passes forward & to the left to emerge b/w the pulmonary trunk and left auricle & gives interventricular branch which runs down in its groove & continuation of left coronary artery is called as circumflex artery Then it runs towards the left anterior coronary sulcus Next it winds round and continuous in the left posterior coronary sulcus upto close to posterior interventericular grooves where it terminate by anastomosing with right coronary artery INTERNAL STRUCTURE OF HEART Four chambers in the heart Rt atrium with rt auricle Rt ventricle Lt atrium with lt auricle Lt ventricle INTERNAL STRUCTURE OF Rt atrium: Cuboidal chamber, smooth (sinus venarum) & rough (musculi pectaniti) parts, four openings Rt auricle SVC IVC Coronary sinus HEART Rt ventricle Occupies most of the ant surface Tapers above into conus arteriorus which is the outflow part Inside of the inflow part is rough due to trabeculae carnae Tricuspid AV valve b/w rt atrium & rt ventricle It is crescent shaped in cross section Rt ventricle Smooth & rough parts are separated by ridge Tricuspid valve has 3 cusps Walls are 3 times thinner than lt vent Each has a free & attached margin Free margins are attached to papillary muscles by cords like a parachute 3 papillary muscles in rt vent The valve prevents backflow while contracting Interventricular septum Strong obliquely placed partition Upper part is membranous Rest is muscular & convex to the rt Pulmonary valve is at the apex of conus art 3 semilunar cusps Valve closes during diastole to prevent backflow LT atrium Forms most of the base Receives opening of lt auricle Also receives 4 pulm veins Leads to lt ventricle through lt AV or Mitral valve Mitral valve has 2 cusps Prevents backflow during systole Circulation of blood through heart Lt ventricle Forms the apex & pulm surface 3 times thicker walls Conical cavity Numerous muscles Out flow part is anterosuperior Aortic orifice lies at the summit of outflow part It has 3 c Semilunar cusps to prevent backflow during diastole ARTERIAL SYSTEM VENOUS SYSTEM BLOOD SUPPLY OF HEART Vasculature of the heart Vessels are embedded in the fat just deep to the epicardium Vessels receive both sympathetic & para sympathetic supply Coronary arteries are the first branches from aorta Vasculature of the heart Arterial supply of heart Rt coronary artery Arises from rt aortic sinus Descends in the coronary groove Branches Rt atrial SA nodal branch Rt marginal branch for the rt border AV nodal branch Posterior interventricular branches Area of supply of rt artery Rt atrium Most of rt ventricle Diaphragmatic part of rt ventricle Post third of IV septum SA node ( in 60 % people ) AV node ( in 80 % people ) Left coronary artery Arises from lt aortic sinus Runs towards lt in the AV groove Branches SA nodal branch Anterior interventricular branch Circumflex branch Lt marginal branch Area of supply of lt artery Lt atrium Most of the lt ventricle Part of rt ventricle Ant two third of IV septum SA node ( in 40 % people ) Vasculature of the heart Vasculature of the heart Dominence of the rt or lt side It depends on the posterior inter ventricular branch Rt artery is dominant in75 % people Lt is dominant in 10 % Co-dominance in 15 % Venous drainage of heart Coronary sinus which drains most part of the heart via numerous small tributaries Coronary sinus drains into the rt atrium Small veins that drain directly into the rt atrium Venous drainage of heart Venous drainage Tributaries of the coronary sinus Great cardiac vein Middle cardiac vein Small cardiac veins Lt post ventricular vein Lt marginal vein MI & bypass grafting PERICARDIUM:Fibrous Pericardium Serous Pericardium Epicardium or Visceral Pericardium Parietal Pericardium FIBROUS PERICARDIUM (Deriud from septum transversum) Def :Conical , tough, fibers single layer sac which support the delicate period layer of the serous pericardium & firmly adherent to it. CHARACTERISTS OF FIBROUS PERICARDIUM 1: Apex is blunt and fused with the roots of the great vessels and the pericardium fascia behind the sternal angle. 2: Base is broad & lies on diaphragm and in seprably blended with the central of the diaphragm. But in lawer animal it is separated from diaphragm. 3: Anteriorly it is connected to the upper and lower ends of body of sternum by weak 4: Posteriory related to principal brochi oesophagus with nerve plexus around it, and desending thoracice aorta. 5: On each side (right & left) related to mediastinal pleura, mediastinal surface of the lung, pheremic nerve and pericardio phermic vessels. SEROUS PERICARDIUM (1)Perietal Pericardium (outer) Visceral Pericardium (epicardium) (inner) Double layer serous membrem line by mesothlium, having postential space known as pericardial cavity, containing thin layer (film) of serous fluid which lubericate the apposed during continuous heart beat CONTENTS OF PERICARDIUM 1: Heart & cardiac vessels and nervous. 2: Ascendimg aorta. 3: Pulmonary Trunk 4: lower ½ half of Superior Vena cava. 5: Terminal parts of inferior vena cava. 6: Terminal parts of 4 Pulmonary Veins. SINUES OF PERICARDIUM: Oblique sinous of pericardium Transverse sinus of pericardium TRANSVERSE SINUS: B/w Areterial & Venous tubes i.e , arterial tubes eneloses the asending aorta and pulmonary trunk and the Venous tubes enelosed 2 venae cavac and 4 pulmonary Veins & the passage b/w arterial & Venous tubes is known as transverse sinus. OBLIQUE SINUS OF PARICARDIUM: A narrow gap behind stomach. It is bounded anteriorly by the left atrium and posteriory by the parietal pericardium. Functionally, since permits the Pulsatiom of left artium. ARTERIAL SUPPLY:Branches of:(i) Internal thoracic of artery. (ii) Muscular pherenic artery. (iii) Desending thoracic aorta. NERVE SUPPLY:Fibrous & parietal percardia are pain sensitive & Supplied by phrenie nerve Epicardium is supplied automatic nerves of the heart and pain insensitiue. Pain of peri-carditis originates in the pericardium alone. Pain of angina (cardiac pain) originates in the muscles of the vessels. (1)CONTRICTIUE PERICARDITIS: And pericarditis with effusion cause ‘cardiac temponad’ where the heart can not dilate freely. Heart is not filled properly and the cardiac output is diminshed. There is marked staris (Stagnation) of the venous blood in the whole body, neck veins are excessinely prominent, liver is enlarged and the pulse is feeble with a pulsus pericardium character. (Marked decerased during mspiration) (2)PERICARDIUM IN TERMINAL URAEMIA) (3) Pericardial effusion can be drained by puncturing in 5th-6th inter-costal space just lateral to the apex beat or in the angle b/w xiphoid process and left costal margin eith meedle direction upward & backward & to the left. Pericardium Double walled fibroserous sac Tough external fibrous layer Bound to diaphragm by pericardiacophrenic ligament To sternum by sternipericardiac ligament The internal surface is lined by glistening serous membrane called the parietal layer Pericardium Pericardium The serous layer is reflected on the heart as the visceral layer It is closely adherent to cardiac muscle & is also called the epicardium The fibrous pericardium protects the heart against sudden overfilling It fuses with adventitia of all the great vessels Pericardial cavity Potential space Thin film of fluid Heart can move or beat without friction Two sinuses present b/w the roots of great vessels Transverse sinus Oblique sinus Pericardial sinuses Collection of fluid in the pericardial cavity Pericardial effusion Conducting system of heart Components Sinuatrial node Atrioventricular node Atrioventricular bundle Rt bundle branch Lt bundle branch Perkunji fibres Conducting system Conducting system Conducting system Conducting system of heart Electrocardiograph