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Transcript
Regulation of thyroid hormone secretion. Myriad neural inputs influence hypothalamic secretion of thyrotropin-releasing hormone (TRH). TRH stimulates release of thyrotropin (TSH, thyroid-stimulating hormone) from the anterior pituitary; TSH stimulates the synthesis and release of the thyroid hormones T3 and T4. T3 and T4 feed back to inhibit the synthesis and release of TRH and TSH. Somatostatin (SST) can inhibit TRH action, as can dopamine and high concentrations of glucocorticoids. Low levels of I– are required for thyroxine synthesis, but high levels inhibit thyroxin synthesis and release. Source: Thyroid and Anti-Thyroid Drugs, Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e Citation: Hilal-Dandan R, Brunton LL. Goodman and Gilman's Manual of Pharmacology and Therapeutics, 2e; 2016 Available at: http://mhmedical.com/ Accessed: May 04, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved
