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Capitulo 22 Sistema inmune Farmacoterapia Dra. González Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Lymphoid Organs Lymph nodes Thymus Spleen Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Figure 22–7 The Structure of a Lymph Node. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Lymph Node A filter Purifies lymph before return to venous circulation Removes Debris Pathogens 99% of antigens Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Figure 22–8 The Thymus. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Figure 22–8 The Thymus. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Figure 22–9 The Spleen. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Structures of Body Defenses Figure 22–9 The Spleen. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Nonspecific Defenses Figure 22–10 Nonspecific Defenses. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Nonspecific Defenses Figure 22–11 How Natural Killer Cells Kill Cellular Targets. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Nonspecific Defenses Interferons Proteins (cytokines) released by activated lymphocytes and macrophages Cytokines Chemical messengers released by tissue cells To coordinate local activities To act as hormones to affect whole body Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Nonspecific Defenses Cardinal Signs and Symptoms Swelling (tumor) Redness (rubor) Heat (calor) Pain (dolor) Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Forms of Immunity Innate Present at birth Acquired After birth Active Antibodies develop after exposure to antigen Passive Antibodies are transferred from another source Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Active Immunity Naturally acquired Through environmental exposure to pathogens Induced Through vaccines containing pathogens Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Passive Immunity Naturally acquired Antibodies acquired from the mother Induced By an injection of antibodies Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses . Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Four Properties of Immunity Specificity Each T or B cell responds only to a specific antigen and ignores all others Versatility The body produces many types of lymphocytes: – each fights a different type of antigen – active lymphocyte clones itself to fight specific antigen Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Four Properties of Immunity Memory Some active lymphocytes (memory cells): – stay in circulation – provide immunity against new exposure Tolerance Immune system ignores “normal” (self) antigens Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses The Immune Response Two main divisions Cell-mediated immunity (T cells) Antibody-mediated immunity (B cells) Immunity: Cell-Mediated Immunity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Specific Defenses Figure 22–15 An Overview of the Immune Response. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings T Cells and Immunity Figure 22–16 Antigens and MHC Proteins. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings B Cells and Immunity Figure 22–20 The Sensitization and Activation of B Cells. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings B Cells and Immunity Five Heavy-Chain Constant Segments Determine five types of antibodies IgG IgE IgD IgM IgA Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings B Cells and Immunity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings B Cells and Immunity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings B Cells and Immunity Figure 22–21c–d Antibody Structure and Function. Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Immune System Development Fetus can produce immune response (has immunological competence) After exposure to antigen At about 3–4 months Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Development of Immunological Competence Fetal thymus cells migrate to tissues that form T cells Liver and bone marrow produce B cells 4-month fetus produces IgM antibodies Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Before Birth Maternal IgG antibodies Pass through placenta Provide passive immunity to fetus After Birth Mother’s milk provides IgA antibodies While passive immunity is lost Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Normal Resistance Infant produces IgG antibodies through exposure to antigens Antibody, B cell, and T cell levels slowly rise to adult levels About age 12 Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Immune Disorders Autoimmune disorders Immunodeficiency disease Allergies Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Autoimmune Disorders A malfunction of system that recognizes and ignores “normal” antigens Activated B cells make autoantibodies against body cells Thyroiditis Rheumatoid arthritis Insulin-dependent diabetes mellitus (IDDM) Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Immunodeficiency diseases result from Problems with embryological development of lymphoid tissues: Can result in severe combined immunodeficiency disease (SCID) Viral infections such as HIV Can result in AIDS Immunosuppressive drugs or radiation treatments: Can lead to complete immunological failure Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Allergies Inappropriate or excessive immune responses to antigens Allergens Antigens that trigger allergic reactions Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Anaphylaxis Can be fatal Affects cells throughout body Changes capillary permeability Produce swelling (hives) on skin Smooth muscles of respiratory system contract Make breathing difficult Peripheral vasodilatation Can cause circulatory collapse (anaphylactic shock) Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Antihistamines Drugs that block histamine released by mast cells Can relieve mild symptoms of immediate hypersensitivity Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Stress and the Immune Response Glucocorticoids Secreted to limit immune response Long-term secretion (chronic stress): – inhibits immune response – lowers resistance to disease Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Immune System Development Functions of Glucocorticoids Depression of the inflammatory response Reduction in abundance and activity of phagocytes Inhibition of interleukin secretion Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings Interactions with Other Systems Disorders of the Lymphoid System Three categories affect immune response Disorders resulting from: – an insufficient immune response – an inappropriate immune response – an excessive immune response Copyright © 2009 Pearson Education, Inc., publishing as Pearson Benjamin Cummings